| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Suns | 122 | Grizzlies | 127 |
| November | 6, 2021 | Suns | 118 | Nuggets | 99 |
| November | 8, 2021 | Warriors | 120 | Suns | 103 |
| November | 10, 2021 | Clippers | 123 | Suns | 108 |
| November | 11, 2021 | Suns | 109 | Wolves | 121 |
| November | 14, 2021 | Heat | 98 | Suns | 88 |
| November | 17, 2021 | Suns | 81 | Trailblazers | 91 |
| November | 21, 2021 | Warriors | 138 | Suns | 112 |
| November | 23, 2021 | Trailblazers | 80 | Suns | 119 |
| November | 24, 2021 | Suns | 117 | Jazz | 110 |
| November | 26, 2021 | Rockets | 117 | Suns | 90 |
| November | 28, 2021 | Suns | 109 | Pistons | 102 |
| November | 30, 2021 | Suns | 135 | Cavaliers | 132 |
| December | 2, 2021 | Suns | 91 | Hawks | 101 |
| December | 5, 2021 | Suns | 89 | Bulls | 106 |
| December | 7, 2021 | Suns | 126 | Kings | 114 |
| December | 12, 2021 | Lakers | 115 | Suns | 125 |
| December | 14, 2021 | Suns | 106 | Spurs | 129 |
| December | 15, 2021 | Suns | 108 | Clippers | 131 |
| December | 18, 2021 | Celtics | 115 | Suns | 121 |
| December | 20, 2021 | Suns | 121 | Mavericks | 131 |
| December | 21, 2021 | Hornets | 128 | Suns | 116 |
| December | 26, 2021 | Suns | 88 | Rockets | 104 |
| December | 27, 2021 | Trailblazers | 92 | Suns | 104 |
| December | 29, 2021 | Suns | 101 | Knicks | 114 |
| December | 31, 2021 | Pelicans | 93 | Suns | 108 |
| January | 2, 2022 | Thunder | 117 | Suns | 137 |
| January | 5, 2022 | Suns | 101 | Magic | 128 |
| January | 8, 2022 | Suns | 92 | Pacers | 120 |
| January | 11, 2022 | Suns | 118 | Bucks | 123 |
| January | 13, 2022 | Knicks | 97 | Suns | 90 |
| January | 15, 2022 | Suns | 88 | 76ers | 94 |
| January | 18, 2022 | Spurs | 104 | Suns | 130 |
| January | 20, 2022 | Nuggets | 119 | Suns | 133 |
| January | 23, 2022 | Suns | 116 | Nets | 109 |
| January | 25, 2022 | Grizzlies | 102 | Suns | 114 |
| January | 26, 2022 | Wolves | 123 | Suns | 97 |
| January | 28, 2022 | Suns | 104 | Thunder | 116 |
| January | 29, 2022 | Suns | 101 | Spurs | 116 |
| January | 30, 2022 | Nets | 111 | Suns | 115 |
| January | 31, 2022 | Jazz | 107 | Suns | 121 |
| February | 2, 2022 | Suns | 100 | Pelicans | 93 |
| February | 4, 2022 | Suns | 101 | Grizzlies | 134 |
| February | 6, 2022 | Pacers | 99 | Suns | 130 |
| February | 13, 2022 | Pelicans | 100 | Suns | 104 |
| February | 14, 2022 | Suns | 116 | Lakers | 123 |
| February | 16, 2022 | Suns | 116 | Wolves | 104 |
| February | 17, 2022 | Mavericks | 91 | Suns | 105 |
| February | 20, 2022 | Clippers | 123 | Suns | 133 |
| February | 21, 2022 | Nuggets | 103 | Suns | 125 |
| February | 24, 2022 | Suns | 100 | Mavericks | 116 |
| February | 27, 2022 | Bucks | 116 | Suns | 94 |
| March | 1, 2022 | Jazz | 123 | Suns | 103 |
| March | 4, 2022 | Kings | 102 | Suns | 107 |
| March | 5, 2022 | Suns | 107 | Warriors | 149 |
| March | 7, 2022 | Spurs | 138 | Suns | 131 |
| March | 11, 2022 | Suns | 99 | Hornets | 108 |
| March | 14, 2022 | Wolves | 142 | Suns | 104 |
| March | 17, 2022 | Suns | 100 | Wizards | 108 |
| March | 18, 2022 | Kings | 116 | Suns | 132 |
| March | 21, 2022 | Suns | 107 | Celtics | 114 |
| March | 24, 2022 | Suns | 113 | Lakers | 124 |
| March | 27, 2022 | Suns | 108 | Jazz | 114 |
| March | 31, 2022 | Bulls | 103 | Suns | 114 |
| April | 2, 2022 | Suns | 120 | Raptors | 108 |
| April | 4, 2022 | Mavericks | 96 | Suns | 104 |
| April | 6, 2022 | Suns | 98 | Pelicans | 103 |
| April | 7, 2022 | Wizards | 99 | Suns | 90 |
| April | 9, 2022 | Suns | 79 | Rockets | 108 |
| April | 11, 2022 | Cavaliers | 124 | Suns | 94 |
| April | 12, 2022 | Magic | 128 | Suns | 109 |
| April | 14, 2022 | Suns | 108 | Clippers | 97 |
| April | 15, 2022 | Suns | 101 | Warriors | 108 |
| April | 17, 2022 | Raptors | 100 | Suns | 81 |
| April | 19, 2022 | Hawks | 92 | Suns | 101 |
| April | 20, 2022 | Pistons | 110 | Suns | 119 |
| April | 22, 2022 | Suns | 88 | Thunder | 111 |
| April | 24, 2022 | 76ers | 80 | Suns | 98 |
| April | 26, 2022 | Suns | 89 | Heat | 103 |
| April | 28, 2022 | Rockets | 131 | Suns | 76 |
| April | 29, 2022 | Suns | 100 | Trailblazers | 95 |
| May | 1, 2022 | Thunder | 122 | Suns | 107 |