| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Hornets | 93 | Knicks | 96 |
| November | 6, 2021 | Knicks | 98 | Nets | 114 |
| November | 8, 2021 | Knicks | 83 | Celtics | 97 |
| November | 12, 2021 | Lakers | 103 | Knicks | 119 |
| November | 13, 2021 | Knicks | 84 | Mavericks | 92 |
| November | 15, 2021 | Knicks | 96 | 76ers | 88 |
| November | 18, 2021 | Cavaliers | 114 | Knicks | 105 |
| November | 19, 2021 | Warriors | 118 | Knicks | 91 |
| November | 22, 2021 | Knicks | 94 | Clippers | 112 |
| November | 24, 2021 | Knicks | 98 | Heat | 93 |
| November | 26, 2021 | Pistons | 91 | Knicks | 96 |
| November | 29, 2021 | Knicks | 93 | Wizards | 88 |
| November | 30, 2021 | Bucks | 115 | Knicks | 107 |
| December | 2, 2021 | Knicks | 96 | Warriors | 121 |
| December | 4, 2021 | Pelicans | 79 | Knicks | 99 |
| December | 6, 2021 | Knicks | 100 | Raptors | 123 |
| December | 8, 2021 | Knicks | 88 | Lakers | 97 |
| December | 9, 2021 | Spurs | 98 | Knicks | 104 |
| December | 11, 2021 | Knicks | 83 | Pelicans | 94 |
| December | 13, 2021 | Knicks | 102 | Kings | 135 |
| December | 15, 2021 | Trailblazers | 92 | Knicks | 96 |
| December | 18, 2021 | Rockets | 82 | Knicks | 96 |
| December | 20, 2021 | Knicks | 92 | Magic | 82 |
| December | 22, 2021 | Hawks | 90 | Knicks | 84 |
| December | 25, 2021 | Nets | 100 | Knicks | 106 |
| December | 27, 2021 | Knicks | 91 | Hornets | 104 |
| December | 29, 2021 | Suns | 101 | Knicks | 114 |
| December | 31, 2021 | Knicks | 100 | Wolves | 112 |
| January | 3, 2022 | Heat | 87 | Knicks | 86 |
| January | 5, 2022 | Knicks | 98 | Pacers | 129 |
| January | 8, 2022 | Jazz | 108 | Knicks | 102 |
| January | 10, 2022 | Knicks | 100 | Hawks | 105 |
| January | 13, 2022 | Knicks | 97 | Suns | 90 |
| January | 15, 2022 | Clippers | 93 | Knicks | 77 |
| January | 17, 2022 | Raptors | 97 | Knicks | 100 |
| January | 21, 2022 | Knicks | 106 | Spurs | 128 |
| January | 23, 2022 | Wolves | 100 | Knicks | 97 |
| January | 24, 2022 | Kings | 114 | Knicks | 125 |
| January | 26, 2022 | Knicks | 89 | Nets | 107 |
| January | 28, 2022 | Grizzlies | 85 | Knicks | 95 |
| January | 31, 2022 | Knicks | 94 | Hawks | 100 |
| February | 2, 2022 | Bulls | 95 | Knicks | 76 |
| February | 4, 2022 | Knicks | 87 | Nuggets | 112 |
| February | 5, 2022 | Thunder | 84 | Knicks | 95 |
| February | 7, 2022 | Knicks | 116 | Pacers | 124 |
| February | 13, 2022 | Knicks | 80 | Raptors | 99 |
| February | 15, 2022 | Celtics | 91 | Knicks | 110 |
| February | 18, 2022 | Knicks | 82 | Bucks | 118 |
| February | 20, 2022 | Pistons | 83 | Knicks | 79 |
| February | 21, 2022 | Knicks | 73 | Bulls | 103 |
| February | 23, 2022 | Knicks | 104 | Rockets | 84 |
| February | 25, 2022 | Magic | 118 | Knicks | 108 |
| February | 27, 2022 | 76ers | 100 | Knicks | 105 |
| March | 1, 2022 | Knicks | 97 | Cavaliers | 102 |
| March | 4, 2022 | Hornets | 92 | Knicks | 80 |
| March | 7, 2022 | Knicks | 93 | Heat | 99 |
| March | 9, 2022 | Nuggets | 86 | Knicks | 89 |
| March | 10, 2022 | Knicks | 103 | Grizzlies | 99 |
| March | 12, 2022 | Knicks | 90 | Magic | 126 |
| March | 14, 2022 | Celtics | 104 | Knicks | 120 |
| March | 17, 2022 | Knicks | 72 | Hornets | 106 |
| March | 20, 2022 | Pacers | 89 | Knicks | 103 |
| March | 22, 2022 | Knicks | 104 | Bucks | 114 |
| March | 24, 2022 | Bulls | 95 | Knicks | 89 |
| March | 25, 2022 | Knicks | 76 | Wizards | 98 |
| March | 27, 2022 | Mavericks | 97 | Knicks | 95 |
| March | 29, 2022 | Cavaliers | 113 | Knicks | 106 |
| March | 31, 2022 | Knicks | 100 | Trailblazers | 96 |
| April | 1, 2022 | Knicks | 103 | Jazz | 83 |
| April | 4, 2022 | Bucks | 105 | Knicks | 120 |
| April | 7, 2022 | Knicks | 106 | Pistons | 90 |
| April | 10, 2022 | Knicks | 105 | Celtics | 109 |
| April | 13, 2022 | Hawks | 104 | Knicks | 76 |
| April | 15, 2022 | Knicks | 88 | Pistons | 111 |
| April | 18, 2022 | 76ers | 78 | Knicks | 96 |
| April | 20, 2022 | Wizards | 114 | Knicks | 105 |
| April | 22, 2022 | Nets | 75 | Knicks | 106 |
| April | 23, 2022 | Knicks | 87 | Bulls | 91 |
| April | 25, 2022 | Raptors | 122 | Knicks | 113 |
| April | 27, 2022 | Knicks | 79 | Thunder | 101 |
| April | 29, 2022 | Magic | 140 | Knicks | 134 |
| May | 1, 2022 | Heat | 90 | Knicks | 105 |