| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Suns | 122 | Grizzlies | 127 |
| November | 4, 2021 | Grizzlies | 127 | Nuggets | 109 |
| November | 7, 2021 | Wolves | 127 | Grizzlies | 115 |
| November | 9, 2021 | Grizzlies | 107 | Kings | 115 |
| November | 10, 2021 | Grizzlies | 98 | Hornets | 132 |
| November | 12, 2021 | Heat | 98 | Grizzlies | 110 |
| November | 14, 2021 | Grizzlies | 82 | Bulls | 99 |
| November | 15, 2021 | Grizzlies | 109 | Bucks | 118 |
| November | 18, 2021 | Grizzlies | 92 | Hawks | 104 |
| November | 21, 2021 | Grizzlies | 105 | Pistons | 103 |
| November | 24, 2021 | Clippers | 93 | Grizzlies | 123 |
| November | 25, 2021 | Mavericks | 111 | Grizzlies | 107 |
| November | 28, 2021 | Grizzlies | 104 | Rockets | 95 |
| November | 30, 2021 | 76ers | 75 | Grizzlies | 103 |
| December | 2, 2021 | Grizzlies | 92 | Trailblazers | 97 |
| December | 4, 2021 | Nets | 96 | Grizzlies | 119 |
| December | 5, 2021 | Jazz | 127 | Grizzlies | 99 |
| December | 8, 2021 | Grizzlies | 99 | Warriors | 106 |
| December | 10, 2021 | Grizzlies | 86 | Lakers | 82 |
| December | 12, 2021 | Celtics | 87 | Grizzlies | 96 |
| December | 15, 2021 | Grizzlies | 99 | 76ers | 90 |
| December | 17, 2021 | Grizzlies | 108 | Cavaliers | 105 |
| December | 20, 2021 | Grizzlies | 98 | Wizards | 102 |
| December | 22, 2021 | Magic | 111 | Grizzlies | 124 |
| December | 26, 2021 | Grizzlies | 120 | Mavericks | 123 |
| December | 29, 2021 | Thunder | 119 | Grizzlies | 123 |
| January | 1, 2022 | Grizzlies | 115 | Wolves | 106 |
| January | 3, 2022 | Pistons | 72 | Grizzlies | 78 |
| January | 4, 2022 | Warriors | 102 | Grizzlies | 124 |
| January | 7, 2022 | Pelicans | 91 | Grizzlies | 94 |
| January | 8, 2022 | Grizzlies | 107 | Spurs | 102 |
| January | 10, 2022 | Bucks | 105 | Grizzlies | 104 |
| January | 13, 2022 | Grizzlies | 115 | Nets | 125 |
| January | 16, 2022 | Grizzlies | 95 | Heat | 106 |
| January | 18, 2022 | Raptors | 128 | Grizzlies | 120 |
| January | 21, 2022 | Grizzlies | 114 | Jazz | 115 |
| January | 23, 2022 | Cavaliers | 136 | Grizzlies | 109 |
| January | 25, 2022 | Grizzlies | 102 | Suns | 114 |
| January | 28, 2022 | Grizzlies | 85 | Knicks | 95 |
| January | 30, 2022 | Grizzlies | 101 | Raptors | 125 |
| January | 31, 2022 | Lakers | 98 | Grizzlies | 134 |
| February | 4, 2022 | Suns | 101 | Grizzlies | 134 |
| February | 6, 2022 | Nuggets | 97 | Grizzlies | 124 |
| February | 14, 2022 | Grizzlies | 115 | Clippers | 137 |
| February | 15, 2022 | Grizzlies | 117 | Warriors | 124 |
| February | 17, 2022 | Grizzlies | 86 | Pelicans | 92 |
| February | 18, 2022 | Nuggets | 97 | Grizzlies | 106 |
| February | 21, 2022 | Rockets | 102 | Grizzlies | 105 |
| February | 24, 2022 | Bulls | 106 | Grizzlies | 82 |
| February | 27, 2022 | Grizzlies | 107 | Jazz | 85 |
| February | 28, 2022 | Grizzlies | 150 | Thunder | 151 |
| March | 2, 2022 | Jazz | 105 | Grizzlies | 127 |
| March | 4, 2022 | Grizzlies | 72 | Trailblazers | 98 |
| March | 7, 2022 | Hornets | 89 | Grizzlies | 108 |
| March | 10, 2022 | Knicks | 103 | Grizzlies | 99 |
| March | 12, 2022 | Grizzlies | 79 | Spurs | 98 |
| March | 14, 2022 | Wizards | 104 | Grizzlies | 139 |
| March | 16, 2022 | Warriors | 107 | Grizzlies | 117 |
| March | 19, 2022 | Pelicans | 96 | Grizzlies | 103 |
| March | 21, 2022 | Grizzlies | 106 | Mavericks | 89 |
| March | 24, 2022 | Hawks | 83 | Grizzlies | 121 |
| March | 27, 2022 | Grizzlies | 118 | Clippers | 109 |
| March | 29, 2022 | Trailblazers | 84 | Grizzlies | 101 |
| March | 31, 2022 | Kings | 117 | Grizzlies | 111 |
| April | 2, 2022 | Grizzlies | 109 | Magic | 134 |
| April | 4, 2022 | Grizzlies | 121 | Celtics | 109 |
| April | 5, 2022 | Grizzlies | 114 | Pacers | 128 |
| April | 7, 2022 | Wolves | 112 | Grizzlies | 146 |
| April | 8, 2022 | Grizzlies | 109 | Pelicans | 112 |
| April | 10, 2022 | Pacers | 92 | Grizzlies | 112 |
| April | 13, 2022 | Grizzlies | 125 | Wolves | 124 |
| April | 14, 2022 | Grizzlies | 125 | Lakers | 133 |
| April | 16, 2022 | Clippers | 106 | Grizzlies | 119 |
| April | 17, 2022 | Trailblazers | 87 | Grizzlies | 103 |
| April | 19, 2022 | Grizzlies | 106 | Kings | 118 |
| April | 21, 2022 | Spurs | 123 | Grizzlies | 130 |
| April | 23, 2022 | Rockets | 97 | Grizzlies | 115 |
| April | 25, 2022 | Grizzlies | 115 | Nuggets | 96 |
| April | 26, 2022 | Mavericks | 109 | Grizzlies | 132 |
| April | 28, 2022 | Grizzlies | 101 | Thunder | 82 |
| April | 30, 2022 | Spurs | 117 | Grizzlies | 103 |
| May | 1, 2022 | Kings | 99 | Grizzlies | 116 |
| Post | 1, 2022 | Mavericks | 90 | Grizzlies | 91 |
| Post | 2, 2022 | Mavericks | 79 | Grizzlies | 119 |
| Post | 3, 2022 | Grizzlies | 113 | Mavericks | 83 |
| Post | 4, 2022 | Grizzlies | 114 | Mavericks | 79 |
| Post | 5, 2022 | Mavericks | | Grizzlies | |
| Post | 6, 2022 | Grizzlies | | Mavericks | |
| Post | 7, 2022 | Mavericks | | Grizzlies | |
| Post | 8, 2022 | Grizzlies | 122 | Spurs | 138 |
| Post | 9, 2022 | Grizzlies | 111 | Spurs | 131 |
| Post | 10, 2022 | Spurs | 145 | Grizzlies | 122 |
| Post | 11, 2022 | Spurs | 89 | Grizzlies | 133 |
| Post | 12, 2022 | Grizzlies | 124 | Spurs | 112 |
| Post | 13, 2022 | Spurs | 98 | Grizzlies | 124 |
| Post | 14, 2022 | Grizzlies | 114 | Spurs | 96 |
| Post | 15, 2022 | Grizzlies | 109 | Warriors | 118 |
| Post | 16, 2022 | Grizzlies | 114 | Warriors | 115 |
| Post | 17, 2022 | Warriors | 130 | Grizzlies | 125 |
| Post | 18, 2022 | Warriors | 131 | Grizzlies | 102 |
| Post | 19, 2022 | Grizzlies | | Warriors | |
| Post | 20, 2022 | Warriors | | Grizzlies | |
| Post | 21, 2022 | Grizzlies | | Warriors | |