| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Rockets | 90 | Spurs | 119 |
| November | 5, 2022 | Spurs | 133 | Pelicans | 103 |
| November | 7, 2022 | Pacers | 107 | Spurs | 103 |
| November | 9, 2022 | Wolves | 89 | Spurs | 120 |
| November | 12, 2022 | Spurs | 103 | Thunder | 107 |
| November | 14, 2022 | Spurs | 125 | Magic | 117 |
| November | 17, 2022 | Spurs | 124 | Bulls | 99 |
| November | 19, 2022 | Lakers | 94 | Spurs | 101 |
| November | 20, 2022 | Spurs | 94 | Clippers | 148 |
| November | 23, 2022 | Nets | 86 | Spurs | 111 |
| November | 25, 2022 | Spurs | 113 | Wolves | 120 |
| November | 27, 2022 | Trailblazers | 104 | Spurs | 106 |
| November | 30, 2022 | Spurs | 112 | Kings | 120 |
| December | 1, 2022 | Nuggets | 109 | Spurs | 117 |
| December | 4, 2022 | Spurs | 123 | 76ers | 129 |
| December | 7, 2022 | Spurs | 116 | Wizards | 118 |
| December | 9, 2022 | Spurs | 104 | Knicks | 121 |
| December | 12, 2022 | Spurs | 122 | Rockets | 124 |
| December | 14, 2022 | Suns | 128 | Spurs | 122 |
| December | 16, 2022 | Pistons | 111 | Spurs | 118 |
| December | 18, 2022 | Spurs | 120 | Warriors | 128 |
| December | 21, 2022 | Spurs | 102 | Mavericks | 105 |
| December | 25, 2022 | Spurs | 104 | Lakers | 129 |
| December | 26, 2022 | Spurs | 108 | Jazz | 113 |
| December | 28, 2022 | Bucks | 86 | Spurs | 84 |
| December | 31, 2022 | Spurs | 123 | Clippers | 122 |
| January | 2, 2023 | Cavaliers | 84 | Spurs | 122 |
| January | 5, 2023 | Spurs | 105 | Hawks | 116 |
| January | 8, 2023 | Grizzlies | 112 | Spurs | 130 |
| January | 10, 2023 | Spurs | 93 | Warriors | 112 |
| January | 11, 2023 | Rockets | 127 | Spurs | 90 |
| January | 13, 2023 | Spurs | 62 | Bucks | 101 |
| January | 15, 2023 | Spurs | 128 | Celtics | 94 |
| January | 17, 2023 | Jazz | 121 | Spurs | 117 |
| January | 18, 2023 | Spurs | 112 | Suns | 109 |
| January | 20, 2023 | Thunder | 123 | Spurs | 133 |
| January | 21, 2023 | Knicks | 126 | Spurs | 125 |
| January | 24, 2023 | Spurs | 114 | Lakers | 97 |
| January | 26, 2023 | Magic | 101 | Spurs | 107 |
| January | 29, 2023 | Suns | 112 | Spurs | 128 |
| February | 1, 2023 | Spurs | 120 | Trailblazers | 116 |
| February | 4, 2023 | 76ers | 101 | Spurs | 131 |
| February | 7, 2023 | Spurs | 126 | Wolves | 100 |
| February | 13, 2023 | Hawks | 119 | Spurs | 128 |
| February | 17, 2023 | Spurs | 115 | Kings | 128 |
| February | 19, 2023 | Pelicans | 106 | Spurs | 134 |
| February | 21, 2023 | Spurs | 122 | Heat | 98 |
| February | 24, 2023 | Spurs | 102 | Nets | 100 |
| February | 27, 2023 | Spurs | 101 | Rockets | 127 |
| March | 2, 2023 | Kings | 134 | Spurs | 117 |
| March | 4, 2023 | Spurs | 113 | Raptors | 122 |
| March | 5, 2023 | Celtics | 82 | Spurs | 129 |
| March | 7, 2023 | Spurs | 102 | Suns | 121 |
| March | 9, 2023 | Bulls | 87 | Spurs | 100 |
| March | 11, 2023 | Spurs | 110 | Nuggets | 87 |
| March | 12, 2023 | Grizzlies | 118 | Spurs | 109 |
| March | 14, 2023 | Spurs | 126 | Pistons | 117 |
| March | 15, 2023 | Lakers | 99 | Spurs | 133 |
| March | 18, 2023 | Thunder | 102 | Spurs | 112 |
| March | 20, 2023 | Wolves | 113 | Spurs | 119 |
| March | 23, 2023 | Spurs | 124 | Jazz | 112 |
| March | 24, 2023 | Raptors | 103 | Spurs | 117 |
| March | 26, 2023 | Wizards | 117 | Spurs | 141 |
| March | 27, 2023 | Spurs | 127 | Hornets | 104 |
| March | 29, 2023 | Pelicans | 107 | Spurs | 122 |
| March | 31, 2023 | Spurs | 95 | Pacers | 114 |
| April | 2, 2023 | Spurs | 131 | Cavaliers | 89 |
| April | 4, 2023 | Heat | 99 | Spurs | 111 |
| April | 6, 2023 | Trailblazers | 112 | Spurs | 130 |
| April | 9, 2023 | Clippers | 109 | Spurs | 122 |
| April | 10, 2023 | Nuggets | 89 | Spurs | 104 |
| April | 13, 2023 | Mavericks | 126 | Spurs | 123 |
| April | 16, 2023 | Spurs | 104 | Trailblazers | 94 |
| April | 18, 2023 | Warriors | 116 | Spurs | 119 |
| April | 19, 2023 | Hornets | 106 | Spurs | 114 |
| April | 21, 2023 | Spurs | 125 | Grizzlies | 95 |
| April | 22, 2023 | Jazz | 113 | Spurs | 133 |
| April | 24, 2023 | Kings | 129 | Spurs | 128 |
| April | 26, 2023 | Spurs | 92 | Pelicans | 100 |
| April | 29, 2023 | Spurs | 92 | Mavericks | 118 |
| April | 30, 2023 | Spurs | 76 | Grizzlies | 93 |
| May | 1, 2023 | Clippers | 89 | Spurs | 63 |
| Post | 1, 2023 | Spurs | 117 | Clippers | 90 |
| Post | 2, 2023 | Spurs | 99 | Clippers | 82 |
| Post | 3, 2023 | Clippers | 85 | Spurs | 98 |
| Post | 4, 2023 | Clippers | 106 | Spurs | 102 |
| Post | 5, 2023 | Spurs | 100 | Clippers | 122 |
| Post | 6, 2023 | Clippers | 106 | Spurs | 96 |
| Post | 7, 2023 | Spurs | 107 | Clippers | 113 |