| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Clippers | 114 | Lakers | 108 |
| November | 5, 2022 | Lakers | 84 | Jazz | 112 |
| November | 7, 2022 | Thunder | 111 | Lakers | 108 |
| November | 10, 2022 | Trailblazers | 104 | Lakers | 93 |
| November | 12, 2022 | Lakers | 91 | Knicks | 123 |
| November | 15, 2022 | Lakers | 94 | Nets | 106 |
| November | 17, 2022 | Nuggets | 90 | Lakers | 96 |
| November | 19, 2022 | Lakers | 94 | Spurs | 101 |
| November | 21, 2022 | Raptors | 117 | Lakers | 100 |
| November | 24, 2022 | Lakers | 91 | Warriors | 107 |
| November | 26, 2022 | Wolves | 97 | Lakers | 106 |
| November | 28, 2022 | Lakers | 128 | Celtics | 94 |
| November | 30, 2022 | Lakers | 100 | Wizards | 113 |
| December | 2, 2022 | Lakers | 115 | Kings | 124 |
| December | 4, 2022 | Mavericks | 116 | Lakers | 125 |
| December | 7, 2022 | Pistons | 92 | Lakers | 84 |
| December | 8, 2022 | Knicks | 94 | Lakers | 110 |
| December | 10, 2022 | Grizzlies | 84 | Lakers | 97 |
| December | 12, 2022 | Lakers | 114 | Suns | 121 |
| December | 15, 2022 | Pacers | 107 | Lakers | 84 |
| December | 17, 2022 | Magic | 122 | Lakers | 109 |
| December | 18, 2022 | Lakers | 109 | Jazz | 99 |
| December | 20, 2022 | Cavaliers | 133 | Lakers | 137 |
| December | 22, 2022 | Lakers | 96 | Thunder | 126 |
| December | 25, 2022 | Spurs | 104 | Lakers | 129 |
| December | 28, 2022 | Pelicans | 103 | Lakers | 90 |
| December | 30, 2022 | Lakers | 112 | Hornets | 100 |
| January | 1, 2023 | Lakers | 106 | Hawks | 127 |
| January | 4, 2023 | Lakers | 109 | Raptors | 139 |
| January | 6, 2023 | Rockets | 143 | Lakers | 129 |
| January | 8, 2023 | Lakers | 109 | Trailblazers | 119 |
| January | 10, 2023 | Heat | 129 | Lakers | 116 |
| January | 12, 2023 | Lakers | 104 | Mavericks | 130 |
| January | 16, 2023 | Lakers | 120 | Bulls | 101 |
| January | 19, 2023 | Lakers | 139 | 76ers | 112 |
| January | 20, 2023 | Lakers | 85 | Bucks | 98 |
| January | 21, 2023 | Hawks | 117 | Lakers | 108 |
| January | 24, 2023 | Spurs | 114 | Lakers | 97 |
| January | 27, 2023 | Lakers | 82 | Rockets | 124 |
| January | 28, 2023 | Kings | 114 | Lakers | 90 |
| January | 31, 2023 | Lakers | 119 | Grizzlies | 106 |
| February | 1, 2023 | Lakers | 85 | Nuggets | 92 |
| February | 4, 2023 | Lakers | 116 | Trailblazers | 117 |
| February | 5, 2023 | Lakers | 97 | Clippers | 129 |
| February | 7, 2023 | Hornets | 122 | Lakers | 121 |
| February | 14, 2023 | Suns | 113 | Lakers | 108 |
| February | 17, 2023 | Lakers | 118 | Cavaliers | 123 |
| February | 18, 2023 | Lakers | 92 | Pistons | 116 |
| February | 20, 2023 | Celtics | 91 | Lakers | 106 |
| February | 22, 2023 | Lakers | 109 | Pelicans | 101 |
| February | 24, 2023 | Warriors | 114 | Lakers | 78 |
| February | 26, 2023 | Lakers | 123 | Wolves | 135 |
| February | 28, 2023 | Wizards | 112 | Lakers | 105 |
| March | 2, 2023 | Lakers | 95 | Heat | 132 |
| March | 3, 2023 | Lakers | 114 | Magic | 106 |
| March | 6, 2023 | Trailblazers | 85 | Lakers | 94 |
| March | 7, 2023 | Lakers | 110 | Thunder | 121 |
| March | 9, 2023 | Pelicans | 85 | Lakers | 96 |
| March | 12, 2023 | Lakers | 84 | Pacers | 133 |
| March | 15, 2023 | Lakers | 99 | Spurs | 133 |
| March | 16, 2023 | Kings | 126 | Lakers | 128 |
| March | 19, 2023 | Lakers | 89 | Warriors | 103 |
| March | 22, 2023 | 76ers | 89 | Lakers | 105 |
| March | 24, 2023 | Suns | 119 | Lakers | 130 |
| March | 27, 2023 | Rockets | 122 | Lakers | 90 |
| March | 28, 2023 | Lakers | 94 | Nuggets | 98 |
| March | 30, 2023 | Jazz | 134 | Lakers | 106 |
| April | 1, 2023 | Lakers | 98 | Wolves | 129 |
| April | 2, 2023 | Lakers | 104 | Rockets | 110 |
| April | 4, 2023 | Thunder | 90 | Lakers | 108 |
| April | 7, 2023 | Lakers | 114 | Mavericks | 137 |
| April | 10, 2023 | Nets | 95 | Lakers | 104 |
| April | 13, 2023 | Lakers | 128 | Kings | 142 |
| April | 14, 2023 | Grizzlies | 72 | Lakers | 88 |
| April | 16, 2023 | Bucks | 114 | Lakers | 102 |
| April | 19, 2023 | Bulls | 111 | Lakers | 124 |
| April | 21, 2023 | Mavericks | 130 | Lakers | 86 |
| April | 24, 2023 | Lakers | 92 | Clippers | 117 |
| April | 25, 2023 | Lakers | 63 | Pelicans | 104 |
| April | 27, 2023 | Nuggets | 92 | Lakers | 68 |
| April | 28, 2023 | Warriors | 102 | Lakers | 85 |
| May | 1, 2023 | Wolves | 113 | Lakers | 109 |