| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Bucks | 97 | Hornets | 119 |
| November | 6, 2021 | Hornets | 92 | Magic | 114 |
| November | 7, 2021 | Hornets | 98 | Heat | 94 |
| November | 9, 2021 | Hornets | 93 | Raptors | 125 |
| November | 11, 2021 | Hornets | 98 | Bulls | 101 |
| November | 14, 2021 | Bulls | 88 | Hornets | 109 |
| November | 16, 2021 | Hornets | 82 | 76ers | 92 |
| November | 19, 2021 | Heat | 100 | Hornets | 104 |
| November | 21, 2021 | Thunder | 122 | Hornets | 118 |
| November | 23, 2021 | Cavaliers | 102 | Hornets | 104 |
| November | 26, 2021 | Hawks | 89 | Hornets | 80 |
| November | 29, 2021 | Hornets | 92 | 76ers | 75 |
| December | 1, 2021 | Hornets | 90 | Pistons | 89 |
| December | 3, 2021 | Hornets | 111 | Cavaliers | 89 |
| December | 7, 2021 | 76ers | 75 | Hornets | 108 |
| December | 9, 2021 | Celtics | 98 | Hornets | 135 |
| December | 12, 2021 | Pacers | 116 | Hornets | 120 |
| December | 14, 2021 | Hornets | 99 | Thunder | 108 |
| December | 16, 2021 | Hornets | 91 | Hawks | 99 |
| December | 17, 2021 | Bucks | 119 | Hornets | 114 |
| December | 19, 2021 | Hawks | 88 | Hornets | 91 |
| December | 21, 2021 | Jazz | 100 | Hornets | 115 |
| December | 23, 2021 | Pelicans | 103 | Hornets | 88 |
| December | 27, 2021 | Hornets | 103 | Wolves | 78 |
| December | 29, 2021 | Nuggets | 102 | Hornets | 105 |
| December | 31, 2021 | Hornets | 105 | Knicks | 95 |
| January | 3, 2022 | Pistons | 94 | Hornets | 100 |
| January | 5, 2022 | Knicks | 81 | Hornets | 94 |
| January | 6, 2022 | Lakers | 126 | Hornets | 134 |
| January | 10, 2022 | Cavaliers | 94 | Hornets | 98 |
| January | 12, 2022 | Pistons | 107 | Hornets | 116 |
| January | 14, 2022 | Hornets | 109 | Celtics | 88 |
| January | 16, 2022 | Hornets | 96 | Nets | 84 |
| January | 18, 2022 | Nets | 77 | Hornets | 87 |
| January | 19, 2022 | Hornets | 64 | Wizards | 94 |
| January | 21, 2022 | Magic | 94 | Hornets | 90 |
| January | 23, 2022 | Mavericks | 90 | Hornets | 118 |
| January | 26, 2022 | Hornets | 99 | Nuggets | 89 |
| January | 27, 2022 | Hornets | 83 | Suns | 91 |
| January | 29, 2022 | Hornets | 93 | Clippers | 104 |
| February | 1, 2022 | Hornets | 105 | Trailblazers | 117 |
| February | 2, 2022 | Hornets | 123 | Kings | 130 |
| February | 5, 2022 | Hornets | 101 | Spurs | 122 |
| February | 13, 2022 | Kings | 106 | Hornets | 128 |
| February | 15, 2022 | Suns | 86 | Hornets | 100 |
| February | 16, 2022 | Hornets | 84 | Pacers | 132 |
| February | 19, 2022 | Hornets | 105 | Grizzlies | 108 |
| February | 21, 2022 | Hornets | 101 | Bucks | 129 |
| February | 24, 2022 | Knicks | 87 | Hornets | 91 |
| February | 26, 2022 | Hornets | 99 | Celtics | 118 |
| February | 28, 2022 | Grizzlies | 90 | Hornets | 114 |
| March | 1, 2022 | Bulls | 97 | Hornets | 93 |
| March | 5, 2022 | Clippers | 102 | Hornets | 107 |
| March | 6, 2022 | Hornets | 97 | Mavericks | 107 |
| March | 9, 2022 | Hornets | 77 | Hawks | 94 |
| March | 11, 2022 | Hornets | 105 | Pacers | 108 |
| March | 14, 2022 | Hornets | 122 | Magic | 120 |
| March | 16, 2022 | Wizards | 99 | Hornets | 90 |
| March | 17, 2022 | Nets | 99 | Hornets | 92 |
| March | 19, 2022 | Warriors | 105 | Hornets | 103 |
| March | 21, 2022 | Rockets | 73 | Hornets | 110 |
| March | 23, 2022 | Hornets | 78 | Nets | 91 |
| March | 25, 2022 | Trailblazers | 84 | Hornets | 93 |
| March | 28, 2022 | Heat | 67 | Hornets | 98 |
| March | 30, 2022 | Wizards | 94 | Hornets | 100 |
| March | 31, 2022 | Hornets | 113 | Bucks | 127 |
| April | 2, 2022 | Hornets | 102 | Rockets | 104 |
| April | 6, 2022 | Hornets | 96 | Wizards | 91 |
| April | 8, 2022 | Hornets | 68 | Heat | 94 |
| April | 10, 2022 | 76ers | 81 | Hornets | 93 |
| April | 12, 2022 | Wolves | 104 | Hornets | 94 |
| April | 14, 2022 | Celtics | 92 | Hornets | 108 |
| April | 15, 2022 | Hornets | 98 | Raptors | 116 |
| April | 17, 2022 | Spurs | 105 | Hornets | 77 |
| April | 20, 2022 | Hornets | 105 | Lakers | 118 |
| April | 22, 2022 | Hornets | 110 | Warriors | 103 |
| April | 23, 2022 | Hornets | 88 | Jazz | 125 |
| April | 25, 2022 | Hornets | 110 | Pelicans | 106 |
| April | 27, 2022 | Raptors | 87 | Hornets | 105 |
| April | 29, 2022 | Hornets | 95 | Pistons | 117 |
| April | 30, 2022 | Hornets | 117 | Cavaliers | 122 |
| May | 1, 2022 | Magic | 103 | Hornets | 114 |
| Post | 1, 2022 | Hornets | 86 | Pistons | 114 |
| Post | 2, 2022 | Hornets | 81 | Pistons | 101 |
| Post | 3, 2022 | Pistons | 101 | Hornets | 100 |
| Post | 4, 2022 | Pistons | 109 | Hornets | 86 |
| Post | 5, 2022 | Hornets | | Pistons | |
| Post | 6, 2022 | Pistons | | Hornets | |
| Post | 7, 2022 | Hornets | | Pistons | |