| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Nets | 82 | Pistons | 87 |
| November | 5, 2021 | Pistons | 99 | Bucks | 107 |
| November | 7, 2021 | Hawks | 84 | Pistons | 99 |
| November | 8, 2021 | Mavericks | 73 | Pistons | 81 |
| November | 11, 2021 | Celtics | 98 | Pistons | 120 |
| November | 12, 2021 | 76ers | 69 | Pistons | 103 |
| November | 15, 2021 | Pelicans | 87 | Pistons | 88 |
| November | 16, 2021 | Magic | 93 | Pistons | 86 |
| November | 17, 2021 | Pistons | 103 | Jazz | 98 |
| November | 19, 2021 | Pistons | 103 | Raptors | 87 |
| November | 21, 2021 | Grizzlies | 105 | Pistons | 103 |
| November | 23, 2021 | Pistons | 83 | Hawks | 95 |
| November | 26, 2021 | Pistons | 91 | Knicks | 96 |
| November | 28, 2021 | Suns | 109 | Pistons | 102 |
| December | 1, 2021 | Pistons | 105 | Thunder | 110 |
| December | 2, 2021 | Wizards | 89 | Pistons | 98 |
| December | 5, 2021 | Pistons | 98 | Pacers | 124 |
| December | 6, 2021 | Warriors | 96 | Pistons | 101 |
| December | 7, 2021 | Pistons | 89 | Lakers | 113 |
| December | 10, 2021 | Raptors | 109 | Pistons | 91 |
| December | 12, 2021 | Pistons | 81 | Hornets | 109 |
| December | 15, 2021 | Bucks | 95 | Pistons | 105 |
| December | 16, 2021 | Pistons | 98 | Spurs | 116 |
| December | 19, 2021 | Pistons | 76 | Bulls | 84 |
| December | 22, 2021 | Nets | 83 | Pistons | 95 |
| December | 26, 2021 | Pacers | 119 | Pistons | 113 |
| December | 27, 2021 | Kings | 91 | Pistons | 102 |
| December | 29, 2021 | Rockets | 88 | Pistons | 83 |
| December | 30, 2021 | Bulls | 90 | Pistons | 79 |
| January | 2, 2022 | Bucks | 84 | Pistons | 80 |
| January | 3, 2022 | Pistons | 72 | Grizzlies | 78 |
| January | 5, 2022 | Pistons | 83 | Heat | 89 |
| January | 6, 2022 | Wolves | 73 | Pistons | 103 |
| January | 8, 2022 | Hawks | 82 | Pistons | 75 |
| January | 10, 2022 | Hornets | 83 | Pistons | 81 |
| January | 12, 2022 | Pistons | 97 | Cavaliers | 87 |
| January | 14, 2022 | Pistons | 87 | Wizards | 85 |
| January | 15, 2022 | Pistons | 100 | Kings | 114 |
| January | 18, 2022 | Trailblazers | 51 | Pistons | 67 |
| January | 20, 2022 | Clippers | 94 | Pistons | 96 |
| January | 23, 2022 | Pistons | 84 | Raptors | 74 |
| January | 26, 2022 | Pistons | 85 | Bucks | 110 |
| January | 29, 2022 | Pistons | 90 | Pelicans | 100 |
| January | 30, 2022 | Bulls | 134 | Pistons | 84 |
| February | 2, 2022 | Raptors | 84 | Pistons | 70 |
| February | 6, 2022 | Wizards | 95 | Pistons | 80 |
| February | 7, 2022 | Magic | 101 | Pistons | 110 |
| February | 13, 2022 | Pistons | 87 | Rockets | 88 |
| February | 15, 2022 | Pistons | 74 | Nuggets | 82 |
| February | 18, 2022 | Lakers | 98 | Pistons | 129 |
| February | 20, 2022 | Pistons | 83 | Knicks | 79 |
| February | 22, 2022 | Heat | 83 | Pistons | 91 |
| February | 24, 2022 | Jazz | 86 | Pistons | 108 |
| February | 27, 2022 | Pistons | 115 | Nets | 77 |
| March | 1, 2022 | Pistons | 104 | 76ers | 90 |
| March | 2, 2022 | Pistons | 98 | Mavericks | 94 |
| March | 5, 2022 | Thunder | 92 | Pistons | 103 |
| March | 7, 2022 | Pistons | 91 | Wolves | 84 |
| March | 8, 2022 | Pistons | 121 | Magic | 99 |
| March | 11, 2022 | Pistons | 101 | Warriors | 111 |
| March | 14, 2022 | Spurs | 74 | Pistons | 104 |
| March | 17, 2022 | Pistons | 101 | Celtics | 103 |
| March | 18, 2022 | Pistons | 103 | Bulls | 92 |
| March | 21, 2022 | Hornets | 93 | Pistons | 84 |
| March | 24, 2022 | Pistons | 98 | Cavaliers | 103 |
| March | 25, 2022 | Pistons | 105 | 76ers | 88 |
| March | 28, 2022 | Pistons | 97 | Nets | 89 |
| March | 31, 2022 | Pistons | 122 | Magic | 115 |
| April | 5, 2022 | Pistons | 110 | Clippers | 112 |
| April | 7, 2022 | Knicks | 106 | Pistons | 90 |
| April | 8, 2022 | Pistons | 111 | Wizards | 117 |
| April | 11, 2022 | Pistons | 82 | Heat | 93 |
| April | 13, 2022 | Pistons | 92 | Pacers | 144 |
| April | 15, 2022 | Knicks | 88 | Pistons | 111 |
| April | 17, 2022 | Cavaliers | 114 | Pistons | 116 |
| April | 18, 2022 | Celtics | 117 | Pistons | 121 |
| April | 20, 2022 | Pistons | 110 | Suns | 119 |
| April | 21, 2022 | Heat | 75 | Pistons | 97 |
| April | 24, 2022 | Nuggets | 73 | Pistons | 118 |
| April | 27, 2022 | Pistons | 99 | Hornets | 110 |
| April | 30, 2022 | 76ers | 80 | Pistons | 92 |
| May | 1, 2022 | Pistons | 100 | Trailblazers | 92 |