| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Grizzlies | 104 | Pacers | 118 |
| November | 6, 2020 | Hawks | 107 | Grizzlies | 132 |
| November | 9, 2020 | Grizzlies | 107 | Jazz | 117 |
| November | 12, 2020 | Grizzlies | 104 | Kings | 111 |
| November | 16, 2020 | Suns | 95 | Grizzlies | 135 |
| November | 19, 2020 | Wizards | 105 | Grizzlies | 108 |
| November | 22, 2020 | Grizzlies | 103 | Jazz | 105 |
| November | 24, 2020 | Grizzlies | 120 | Suns | 104 |
| November | 25, 2020 | Grizzlies | 107 | Warriors | 125 |
| November | 27, 2020 | Nuggets | 97 | Grizzlies | 95 |
| November | 30, 2020 | 76ers | 124 | Grizzlies | 129 |
| December | 2, 2020 | Jazz | 114 | Grizzlies | 100 |
| December | 4, 2020 | Grizzlies | 110 | Bucks | 116 |
| December | 6, 2020 | Kings | 106 | Grizzlies | 102 |
| December | 8, 2020 | Grizzlies | 98 | Wolves | 111 |
| December | 9, 2020 | Mavericks | 109 | Grizzlies | 111 |
| December | 11, 2020 | Grizzlies | 112 | Spurs | 117 |
| December | 13, 2020 | Grizzlies | 123 | Clippers | 133 |
| December | 16, 2020 | Knicks | 95 | Grizzlies | 114 |
| December | 18, 2020 | Raptors | 127 | Grizzlies | 119 |
| December | 21, 2020 | Grizzlies | 129 | Nets | 101 |
| December | 23, 2020 | Grizzlies | 128 | 76ers | 104 |
| December | 27, 2020 | Clippers | 112 | Grizzlies | 114 |
| December | 29, 2020 | Grizzlies | 115 | Pelicans | 129 |
| December | 30, 2020 | Lakers | 107 | Grizzlies | 105 |
| January | 1, 2021 | Grizzlies | 105 | Nuggets | 132 |
| January | 3, 2021 | Trailblazers | 122 | Grizzlies | 125 |
| January | 5, 2021 | Heat | 89 | Grizzlies | 99 |
| January | 6, 2021 | Rockets | 100 | Grizzlies | 96 |
| January | 8, 2021 | Grizzlies | 105 | Warriors | 133 |
| January | 11, 2021 | Grizzlies | 113 | Trailblazers | 148 |
| January | 12, 2021 | Grizzlies | 115 | Kings | 117 |
| January | 14, 2021 | Grizzlies | 107 | Lakers | 123 |
| January | 16, 2021 | Cavaliers | 118 | Grizzlies | 127 |
| January | 19, 2021 | Celtics | 102 | Grizzlies | 121 |
| January | 21, 2021 | Grizzlies | 89 | Rockets | 106 |
| January | 23, 2021 | Pistons | 107 | Grizzlies | 124 |
| January | 25, 2021 | Nets | 132 | Grizzlies | 115 |
| January | 26, 2021 | Grizzlies | 133 | Spurs | 146 |
| January | 28, 2021 | Grizzlies | 115 | Pelicans | 139 |
| January | 30, 2021 | Spurs | 140 | Grizzlies | 105 |
| February | 2, 2021 | Grizzlies | 116 | Heat | 104 |
| February | 5, 2021 | Grizzlies | 91 | Rockets | 122 |
| February | 7, 2021 | Bucks | 134 | Grizzlies | 110 |
| February | 14, 2021 | Grizzlies | 126 | Celtics | 140 |
| February | 15, 2021 | Grizzlies | 116 | Raptors | 138 |
| February | 17, 2021 | Pelicans | 138 | Grizzlies | 114 |
| February | 19, 2021 | Hornets | 108 | Grizzlies | 88 |
| February | 21, 2021 | Kings | 149 | Grizzlies | 111 |
| February | 22, 2021 | Pacers | 104 | Grizzlies | 94 |
| February | 24, 2021 | Nuggets | 112 | Grizzlies | 107 |
| February | 26, 2021 | Grizzlies | 104 | Wolves | 134 |
| February | 28, 2021 | Grizzlies | 94 | Hornets | 107 |
| March | 3, 2021 | Grizzlies | 83 | Knicks | 108 |
| March | 5, 2021 | Wolves | 118 | Grizzlies | 105 |
| March | 7, 2021 | Grizzlies | 115 | Thunder | 97 |
| March | 9, 2021 | Pelicans | 120 | Grizzlies | 111 |
| March | 12, 2021 | Spurs | 156 | Grizzlies | 112 |
| March | 13, 2021 | Grizzlies | 105 | Bulls | 135 |
| March | 16, 2021 | Clippers | 133 | Grizzlies | 137 |
| March | 17, 2021 | Grizzlies | 105 | Cavaliers | 124 |
| March | 19, 2021 | Lakers | 103 | Grizzlies | 118 |
| March | 21, 2021 | Bulls | 123 | Grizzlies | 121 |
| March | 24, 2021 | Grizzlies | 99 | Mavericks | 157 |
| March | 25, 2021 | Grizzlies | 117 | Thunder | 96 |
| March | 27, 2021 | Trailblazers | 119 | Grizzlies | 115 |
| March | 30, 2021 | Jazz | 95 | Grizzlies | 106 |
| April | 1, 2021 | Magic | 123 | Grizzlies | 128 |
| April | 4, 2021 | Grizzlies | 134 | Hawks | 125 |
| April | 7, 2021 | Grizzlies | 96 | Wizards | 129 |
| April | 11, 2021 | Rockets | 94 | Grizzlies | 122 |
| April | 13, 2021 | Grizzlies | 112 | Magic | 116 |
| April | 14, 2021 | Wolves | 99 | Grizzlies | 103 |
| April | 16, 2021 | Thunder | 114 | Grizzlies | 139 |
| April | 18, 2021 | Warriors | 128 | Grizzlies | 113 |
| April | 21, 2021 | Grizzlies | 115 | Suns | 110 |
| April | 22, 2021 | Grizzlies | 111 | Clippers | 131 |
| April | 25, 2021 | Grizzlies | 132 | Trailblazers | 99 |
| April | 27, 2021 | Grizzlies | 110 | Mavericks | 122 |
| April | 29, 2021 | Mavericks | 135 | Grizzlies | 117 |
| April | 30, 2021 | Grizzlies | 93 | Pistons | 137 |
| May | 1, 2021 | Warriors | 122 | Grizzlies | 117 |