| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Rockets | 116 | Spurs | 102 |
| November | 5, 2020 | Spurs | 95 | Pelicans | 102 |
| November | 7, 2020 | Pacers | 98 | Spurs | 114 |
| November | 9, 2020 | Wolves | 104 | Spurs | 124 |
| November | 12, 2020 | Spurs | 127 | Thunder | 90 |
| November | 14, 2020 | Spurs | 126 | Magic | 132 |
| November | 17, 2020 | Spurs | 118 | Bulls | 113 |
| November | 19, 2020 | Lakers | 100 | Spurs | 128 |
| November | 20, 2020 | Spurs | 133 | Clippers | 113 |
| November | 23, 2020 | Nets | 100 | Spurs | 102 |
| November | 25, 2020 | Spurs | 127 | Wolves | 113 |
| November | 27, 2020 | Trailblazers | 94 | Spurs | 127 |
| November | 30, 2020 | Spurs | 93 | Kings | 99 |
| December | 1, 2020 | Nuggets | 114 | Spurs | 130 |
| December | 4, 2020 | Spurs | 124 | 76ers | 102 |
| December | 7, 2020 | Spurs | 80 | Wizards | 105 |
| December | 9, 2020 | Spurs | 131 | Knicks | 87 |
| December | 12, 2020 | Spurs | 84 | Rockets | 121 |
| December | 14, 2020 | Suns | 101 | Spurs | 118 |
| December | 16, 2020 | Pistons | 117 | Spurs | 111 |
| December | 18, 2020 | Spurs | 101 | Warriors | 114 |
| December | 21, 2020 | Spurs | 107 | Mavericks | 112 |
| December | 25, 2020 | Spurs | 123 | Lakers | 106 |
| December | 26, 2020 | Spurs | 96 | Jazz | 120 |
| December | 28, 2020 | Bucks | 124 | Spurs | 113 |
| December | 31, 2020 | Spurs | 116 | Clippers | 111 |
| January | 2, 2021 | Cavaliers | 107 | Spurs | 138 |
| January | 5, 2021 | Spurs | 101 | Hawks | 107 |
| January | 8, 2021 | Grizzlies | 123 | Spurs | 138 |
| January | 10, 2021 | Spurs | 121 | Warriors | 123 |
| January | 11, 2021 | Rockets | 94 | Spurs | 99 |
| January | 13, 2021 | Spurs | 121 | Bucks | 126 |
| January | 15, 2021 | Spurs | 116 | Celtics | 100 |
| January | 17, 2021 | Jazz | 81 | Spurs | 120 |
| January | 18, 2021 | Spurs | 123 | Suns | 101 |
| January | 20, 2021 | Thunder | 126 | Spurs | 136 |
| January | 21, 2021 | Knicks | 86 | Spurs | 145 |
| January | 24, 2021 | Spurs | 120 | Lakers | 121 |
| January | 26, 2021 | Magic | 114 | Spurs | 128 |
| January | 29, 2021 | Suns | 117 | Spurs | 125 |
| February | 1, 2021 | Spurs | 109 | Trailblazers | 111 |
| February | 4, 2021 | 76ers | 104 | Spurs | 122 |
| February | 7, 2021 | Spurs | 115 | Wolves | 117 |
| February | 14, 2021 | Hawks | 93 | Spurs | 119 |
| February | 17, 2021 | Spurs | 86 | Kings | 62 |
| February | 19, 2021 | Pelicans | 85 | Spurs | 121 |
| February | 21, 2021 | Spurs | 116 | Heat | 106 |
| February | 24, 2021 | Spurs | 140 | Nets | 99 |
| February | 27, 2021 | Spurs | 87 | Rockets | 99 |
| March | 2, 2021 | Kings | 92 | Spurs | 89 |
| March | 4, 2021 | Spurs | 104 | Raptors | 115 |
| March | 5, 2021 | Celtics | 92 | Spurs | 125 |
| March | 7, 2021 | Spurs | 122 | Suns | 114 |
| March | 9, 2021 | Bulls | 108 | Spurs | 139 |
| March | 11, 2021 | Spurs | 116 | Nuggets | 108 |
| March | 12, 2021 | Grizzlies | 114 | Spurs | 120 |
| March | 14, 2021 | Spurs | 119 | Pistons | 107 |
| March | 15, 2021 | Lakers | 129 | Spurs | 123 |
| March | 18, 2021 | Thunder | 106 | Spurs | 130 |
| March | 20, 2021 | Wolves | 82 | Spurs | 121 |
| March | 23, 2021 | Spurs | 116 | Jazz | 103 |
| March | 24, 2021 | Raptors | 81 | Spurs | 123 |
| March | 26, 2021 | Wizards | 121 | Spurs | 125 |
| March | 27, 2021 | Spurs | 106 | Hornets | 84 |
| March | 29, 2021 | Pelicans | 103 | Spurs | 116 |
| March | 31, 2021 | Spurs | 110 | Pacers | 123 |
| April | 2, 2021 | Spurs | 117 | Cavaliers | 100 |
| April | 4, 2021 | Heat | 95 | Spurs | 135 |
| April | 6, 2021 | Trailblazers | 85 | Spurs | 115 |
| April | 9, 2021 | Clippers | 120 | Spurs | 130 |
| April | 10, 2021 | Nuggets | 102 | Spurs | 128 |
| April | 13, 2021 | Mavericks | 77 | Spurs | 89 |
| April | 16, 2021 | Spurs | 101 | Trailblazers | 99 |
| April | 18, 2021 | Warriors | 98 | Spurs | 111 |
| April | 19, 2021 | Hornets | 92 | Spurs | 98 |
| April | 21, 2021 | Spurs | 138 | Grizzlies | 118 |
| April | 22, 2021 | Jazz | 109 | Spurs | 108 |
| April | 24, 2021 | Kings | 105 | Spurs | 102 |
| April | 26, 2021 | Spurs | 111 | Pelicans | 98 |
| April | 29, 2021 | Spurs | 104 | Mavericks | 95 |
| April | 30, 2021 | Spurs | 127 | Grizzlies | 112 |
| May | 1, 2021 | Clippers | 113 | Spurs | 96 |
| Post | 1, 2021 | Thunder | 89 | Spurs | 130 |
| Post | 2, 2021 | Thunder | 109 | Spurs | 112 |
| Post | 3, 2021 | Spurs | 112 | Thunder | 113 |
| Post | 4, 2021 | Spurs | 96 | Thunder | 106 |
| Post | 5, 2021 | Thunder | 102 | Spurs | 99 |
| Post | 6, 2021 | Spurs | 103 | Thunder | 128 |
| Post | 7, 2021 | Thunder | | Spurs | |