| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Clippers | 107 | Lakers | 131 |
| November | 5, 2020 | Lakers | 109 | Jazz | 127 |
| November | 7, 2020 | Thunder | 114 | Lakers | 122 |
| November | 10, 2020 | Trailblazers | 92 | Lakers | 126 |
| November | 12, 2020 | Lakers | 98 | Knicks | 122 |
| November | 15, 2020 | Lakers | 105 | Nets | 113 |
| November | 17, 2020 | Nuggets | 118 | Lakers | 144 |
| November | 19, 2020 | Lakers | 96 | Spurs | 143 |
| November | 21, 2020 | Raptors | 129 | Lakers | 126 |
| November | 24, 2020 | Lakers | 93 | Warriors | 135 |
| November | 26, 2020 | Wolves | 122 | Lakers | 109 |
| November | 28, 2020 | Lakers | 133 | Celtics | 117 |
| November | 30, 2020 | Lakers | 124 | Wizards | 120 |
| December | 2, 2020 | Lakers | 112 | Kings | 123 |
| December | 4, 2020 | Mavericks | 102 | Lakers | 124 |
| December | 7, 2020 | Pistons | 101 | Lakers | 106 |
| December | 8, 2020 | Knicks | 92 | Lakers | 122 |
| December | 10, 2020 | Grizzlies | 109 | Lakers | 98 |
| December | 12, 2020 | Lakers | 113 | Suns | 143 |
| December | 15, 2020 | Pacers | 107 | Lakers | 113 |
| December | 17, 2020 | Magic | 122 | Lakers | 136 |
| December | 18, 2020 | Lakers | 115 | Jazz | 119 |
| December | 20, 2020 | Cavaliers | 102 | Lakers | 132 |
| December | 22, 2020 | Lakers | 110 | Thunder | 120 |
| December | 25, 2020 | Spurs | 129 | Lakers | 96 |
| December | 28, 2020 | Pelicans | 115 | Lakers | 131 |
| December | 30, 2020 | Lakers | 106 | Hornets | 104 |
| January | 1, 2021 | Lakers | 125 | Hawks | 133 |
| January | 4, 2021 | Lakers | 111 | Raptors | 119 |
| January | 6, 2021 | Rockets | 132 | Lakers | 130 |
| January | 8, 2021 | Lakers | 149 | Trailblazers | 128 |
| January | 10, 2021 | Heat | 104 | Lakers | 116 |
| January | 12, 2021 | Lakers | 114 | Mavericks | 121 |
| January | 16, 2021 | Lakers | 115 | Bulls | 118 |
| January | 19, 2021 | Lakers | 113 | 76ers | 108 |
| January | 20, 2021 | Lakers | 89 | Bucks | 91 |
| January | 21, 2021 | Hawks | 101 | Lakers | 96 |
| January | 24, 2021 | Spurs | 120 | Lakers | 116 |
| January | 27, 2021 | Lakers | 92 | Rockets | 111 |
| January | 28, 2021 | Kings | 91 | Lakers | 98 |
| January | 31, 2021 | Lakers | 107 | Grizzlies | 120 |
| February | 1, 2021 | Lakers | 138 | Nuggets | 115 |
| February | 4, 2021 | Lakers | 102 | Trailblazers | 121 |
| February | 5, 2021 | Lakers | 126 | Clippers | 131 |
| February | 7, 2021 | Hornets | 111 | Lakers | 91 |
| February | 14, 2021 | Suns | 100 | Lakers | 98 |
| February | 17, 2021 | Lakers | 104 | Cavaliers | 114 |
| February | 18, 2021 | Lakers | 125 | Pistons | 103 |
| February | 20, 2021 | Celtics | 115 | Lakers | 109 |
| February | 22, 2021 | Lakers | 118 | Pelicans | 120 |
| February | 24, 2021 | Warriors | 121 | Lakers | 118 |
| February | 26, 2021 | Lakers | 119 | Wolves | 116 |
| February | 28, 2021 | Wizards | 98 | Lakers | 127 |
| March | 2, 2021 | Lakers | 119 | Heat | 105 |
| March | 3, 2021 | Lakers | 117 | Magic | 134 |
| March | 6, 2021 | Trailblazers | 91 | Lakers | 132 |
| March | 7, 2021 | Lakers | 118 | Thunder | 121 |
| March | 9, 2021 | Pelicans | 114 | Lakers | 125 |
| March | 12, 2021 | Lakers | 116 | Pacers | 123 |
| March | 15, 2021 | Lakers | 91 | Spurs | 104 |
| March | 16, 2021 | Kings | 100 | Lakers | 85 |
| March | 19, 2021 | Lakers | 119 | Warriors | 114 |
| March | 22, 2021 | 76ers | 78 | Lakers | 123 |
| March | 24, 2021 | Suns | 116 | Lakers | 136 |
| March | 27, 2021 | Rockets | 98 | Lakers | 109 |
| March | 28, 2021 | Lakers | 125 | Nuggets | 117 |
| March | 30, 2021 | Jazz | 123 | Lakers | 117 |
| April | 1, 2021 | Lakers | 119 | Wolves | 103 |
| April | 2, 2021 | Lakers | 108 | Rockets | 121 |
| April | 4, 2021 | Thunder | 106 | Lakers | 132 |
| April | 7, 2021 | Lakers | 108 | Mavericks | 110 |
| April | 10, 2021 | Nets | 139 | Lakers | 122 |
| April | 13, 2021 | Lakers | 85 | Kings | 87 |
| April | 14, 2021 | Grizzlies | 122 | Lakers | 110 |
| April | 16, 2021 | Bucks | 109 | Lakers | 117 |
| April | 19, 2021 | Bulls | 113 | Lakers | 122 |
| April | 21, 2021 | Mavericks | 83 | Lakers | 102 |
| April | 24, 2021 | Lakers | 120 | Clippers | 128 |
| April | 25, 2021 | Lakers | 111 | Pelicans | 117 |
| April | 27, 2021 | Nuggets | 104 | Lakers | 121 |
| April | 28, 2021 | Warriors | 102 | Lakers | 106 |
| May | 1, 2021 | Wolves | 112 | Lakers | 117 |