| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Suns | 103 | Grizzlies | 126 |
| November | 4, 2020 | Grizzlies | 106 | Nuggets | 96 |
| November | 7, 2020 | Wolves | 94 | Grizzlies | 113 |
| November | 9, 2020 | Grizzlies | 97 | Kings | 92 |
| November | 10, 2020 | Grizzlies | 89 | Hornets | 88 |
| November | 12, 2020 | Heat | 105 | Grizzlies | 111 |
| November | 14, 2020 | Grizzlies | 105 | Bulls | 74 |
| November | 15, 2020 | Grizzlies | 94 | Bucks | 115 |
| November | 18, 2020 | Grizzlies | 82 | Hawks | 109 |
| November | 21, 2020 | Grizzlies | 117 | Pistons | 120 |
| November | 24, 2020 | Clippers | 93 | Grizzlies | 98 |
| November | 25, 2020 | Mavericks | 114 | Grizzlies | 116 |
| November | 28, 2020 | Grizzlies | 100 | Rockets | 106 |
| November | 30, 2020 | 76ers | 106 | Grizzlies | 116 |
| December | 2, 2020 | Grizzlies | 117 | Trailblazers | 130 |
| December | 4, 2020 | Nets | 81 | Grizzlies | 103 |
| December | 5, 2020 | Jazz | 122 | Grizzlies | 109 |
| December | 8, 2020 | Grizzlies | 94 | Warriors | 101 |
| December | 10, 2020 | Grizzlies | 109 | Lakers | 98 |
| December | 12, 2020 | Celtics | 90 | Grizzlies | 109 |
| December | 15, 2020 | Grizzlies | 84 | 76ers | 112 |
| December | 17, 2020 | Grizzlies | 126 | Cavaliers | 115 |
| December | 20, 2020 | Grizzlies | 118 | Wizards | 104 |
| December | 22, 2020 | Magic | 96 | Grizzlies | 130 |
| December | 26, 2020 | Grizzlies | 108 | Mavericks | 98 |
| December | 29, 2020 | Thunder | 109 | Grizzlies | 119 |
| January | 1, 2021 | Grizzlies | 129 | Wolves | 110 |
| January | 3, 2021 | Pistons | 125 | Grizzlies | 104 |
| January | 4, 2021 | Warriors | 93 | Grizzlies | 104 |
| January | 7, 2021 | Pelicans | 119 | Grizzlies | 108 |
| January | 8, 2021 | Grizzlies | 96 | Spurs | 94 |
| January | 10, 2021 | Bucks | 85 | Grizzlies | 94 |
| January | 13, 2021 | Grizzlies | 96 | Nets | 97 |
| January | 16, 2021 | Grizzlies | 110 | Heat | 106 |
| January | 18, 2021 | Raptors | 114 | Grizzlies | 99 |
| January | 21, 2021 | Grizzlies | 116 | Jazz | 95 |
| January | 23, 2021 | Cavaliers | 107 | Grizzlies | 95 |
| January | 25, 2021 | Grizzlies | 111 | Suns | 141 |
| January | 28, 2021 | Grizzlies | 89 | Knicks | 85 |
| January | 30, 2021 | Grizzlies | 116 | Raptors | 91 |
| January | 31, 2021 | Lakers | 107 | Grizzlies | 120 |
| February | 4, 2021 | Suns | 102 | Grizzlies | 114 |
| February | 6, 2021 | Nuggets | 92 | Grizzlies | 113 |
| February | 14, 2021 | Grizzlies | 102 | Clippers | 94 |
| February | 15, 2021 | Grizzlies | 110 | Warriors | 86 |
| February | 17, 2021 | Grizzlies | 106 | Pelicans | 120 |
| February | 18, 2021 | Nuggets | 101 | Grizzlies | 117 |
| February | 21, 2021 | Rockets | 92 | Grizzlies | 94 |
| February | 24, 2021 | Bulls | 113 | Grizzlies | 100 |
| February | 27, 2021 | Grizzlies | 108 | Jazz | 114 |
| February | 28, 2021 | Grizzlies | 110 | Thunder | 112 |
| March | 2, 2021 | Jazz | 121 | Grizzlies | 113 |
| March | 4, 2021 | Grizzlies | 94 | Trailblazers | 123 |
| March | 7, 2021 | Hornets | 108 | Grizzlies | 86 |
| March | 10, 2021 | Knicks | 89 | Grizzlies | 123 |
| March | 12, 2021 | Grizzlies | 101 | Spurs | 110 |
| March | 14, 2021 | Wizards | 110 | Grizzlies | 106 |
| March | 16, 2021 | Warriors | 118 | Grizzlies | 107 |
| March | 19, 2021 | Pelicans | 105 | Grizzlies | 88 |
| March | 21, 2021 | Grizzlies | 96 | Mavericks | 105 |
| March | 24, 2021 | Hawks | 90 | Grizzlies | 112 |
| March | 27, 2021 | Grizzlies | 121 | Clippers | 96 |
| March | 29, 2021 | Trailblazers | 118 | Grizzlies | 144 |
| March | 31, 2021 | Kings | 95 | Grizzlies | 88 |
| April | 2, 2021 | Grizzlies | 113 | Magic | 118 |
| April | 4, 2021 | Grizzlies | 133 | Celtics | 132 |
| April | 5, 2021 | Grizzlies | 96 | Pacers | 104 |
| April | 7, 2021 | Wolves | 107 | Grizzlies | 110 |
| April | 8, 2021 | Grizzlies | 102 | Pelicans | 106 |
| April | 10, 2021 | Pacers | 108 | Grizzlies | 98 |
| April | 13, 2021 | Grizzlies | 119 | Wolves | 90 |
| April | 14, 2021 | Grizzlies | 122 | Lakers | 110 |
| April | 16, 2021 | Clippers | 104 | Grizzlies | 108 |
| April | 17, 2021 | Trailblazers | 105 | Grizzlies | 115 |
| April | 19, 2021 | Grizzlies | 88 | Kings | 94 |
| April | 21, 2021 | Spurs | 100 | Grizzlies | 103 |
| April | 23, 2021 | Rockets | 81 | Grizzlies | 94 |
| April | 25, 2021 | Grizzlies | 105 | Nuggets | 101 |
| April | 26, 2021 | Mavericks | 92 | Grizzlies | 108 |
| April | 28, 2021 | Grizzlies | 123 | Thunder | 113 |
| April | 30, 2021 | Spurs | 115 | Grizzlies | 98 |
| May | 1, 2021 | Kings | 106 | Grizzlies | 101 |
| Post | 1, 2021 | Grizzlies | 109 | Rockets | 92 |
| Post | 2, 2021 | Grizzlies | 87 | Rockets | 91 |
| Post | 3, 2021 | Rockets | 70 | Grizzlies | 103 |
| Post | 4, 2021 | Rockets | 99 | Grizzlies | 93 |
| Post | 5, 2021 | Grizzlies | 78 | Rockets | 102 |
| Post | 6, 2021 | Rockets | 95 | Grizzlies | 100 |
| Post | 7, 2021 | Grizzlies | 81 | Rockets | 92 |