| month | day | visitor | score | home | score |
|---|
| November | 3, 2022 | Kings | 107 | Trailblazers | 104 |
| November | 5, 2022 | Trailblazers | 93 | Mavericks | 103 |
| November | 8, 2022 | Trailblazers | 87 | Cavaliers | 93 |
| November | 10, 2022 | Trailblazers | 104 | Lakers | 93 |
| November | 13, 2022 | Trailblazers | 112 | Wolves | 107 |
| November | 15, 2022 | Wizards | 102 | Trailblazers | 110 |
| November | 17, 2022 | Suns | 109 | Trailblazers | 100 |
| November | 19, 2022 | Trailblazers | 89 | Nuggets | 88 |
| November | 21, 2022 | Bucks | 92 | Trailblazers | 77 |
| November | 23, 2022 | Trailblazers | 113 | Suns | 97 |
| November | 25, 2022 | Hawks | 91 | Trailblazers | 90 |
| November | 27, 2022 | Trailblazers | 104 | Spurs | 106 |
| November | 28, 2022 | Thunder | 131 | Trailblazers | 97 |
| November | 30, 2022 | Trailblazers | 105 | Pacers | 106 |
| December | 2, 2022 | Grizzlies | 90 | Trailblazers | 103 |
| December | 5, 2022 | Trailblazers | 102 | Heat | 104 |
| December | 6, 2022 | Trailblazers | 98 | 76ers | 90 |
| December | 8, 2022 | Trailblazers | 108 | Raptors | 118 |
| December | 11, 2022 | Rockets | 104 | Trailblazers | 108 |
| December | 13, 2022 | Clippers | 79 | Trailblazers | 80 |
| December | 15, 2022 | Trailblazers | 101 | Knicks | 93 |
| December | 17, 2022 | Trailblazers | 118 | Celtics | 113 |
| December | 20, 2022 | Celtics | 100 | Trailblazers | 129 |
| December | 21, 2022 | Trailblazers | 86 | Warriors | 65 |
| December | 23, 2022 | Pelicans | 114 | Trailblazers | 120 |
| December | 26, 2022 | Wolves | 116 | Trailblazers | 124 |
| December | 27, 2022 | Trailblazers | 107 | Suns | 113 |
| December | 29, 2022 | Mavericks | 107 | Trailblazers | 109 |
| December | 30, 2022 | Trailblazers | 102 | Jazz | 83 |
| January | 2, 2023 | Trailblazers | 107 | Kings | 108 |
| January | 5, 2023 | Clippers | 83 | Trailblazers | 81 |
| January | 8, 2023 | Lakers | 109 | Trailblazers | 119 |
| January | 10, 2023 | Trailblazers | 107 | Nuggets | 95 |
| January | 11, 2023 | Jazz | 99 | Trailblazers | 107 |
| January | 13, 2023 | Trailblazers | 98 | Magic | 92 |
| January | 15, 2023 | Trailblazers | 96 | Warriors | 89 |
| January | 18, 2023 | Trailblazers | 82 | Pistons | 89 |
| January | 21, 2023 | Trailblazers | 102 | Bulls | 125 |
| January | 23, 2023 | Trailblazers | 93 | Hornets | 83 |
| January | 25, 2023 | Rockets | 83 | Trailblazers | 106 |
| January | 28, 2023 | Trailblazers | 96 | Hawks | 103 |
| February | 1, 2023 | Spurs | 120 | Trailblazers | 116 |
| February | 4, 2023 | Lakers | 116 | Trailblazers | 117 |
| February | 7, 2023 | Mavericks | 115 | Trailblazers | 91 |
| February | 11, 2023 | Trailblazers | 101 | Wizards | 116 |
| February | 15, 2023 | Magic | 72 | Trailblazers | 109 |
| February | 17, 2023 | Pacers | 129 | Trailblazers | 102 |
| February | 18, 2023 | 76ers | 90 | Trailblazers | 105 |
| February | 20, 2023 | Trailblazers | 111 | Pelicans | 86 |
| February | 22, 2023 | Nets | 105 | Trailblazers | 61 |
| February | 25, 2023 | Nuggets | 87 | Trailblazers | 119 |
| February | 27, 2023 | Trailblazers | 114 | Kings | 109 |
| March | 1, 2023 | Raptors | 88 | Trailblazers | 109 |
| March | 3, 2023 | Trailblazers | 107 | Rockets | 112 |
| March | 4, 2023 | Grizzlies | 82 | Trailblazers | 97 |
| March | 6, 2023 | Trailblazers | 85 | Lakers | 94 |
| March | 9, 2023 | Warriors | 100 | Trailblazers | 96 |
| March | 12, 2023 | Heat | 103 | Trailblazers | 132 |
| March | 13, 2023 | Hornets | 85 | Trailblazers | 106 |
| March | 15, 2023 | Trailblazers | 92 | Mavericks | 99 |
| March | 18, 2023 | Warriors | 96 | Trailblazers | 98 |
| March | 21, 2023 | Cavaliers | 73 | Trailblazers | 97 |
| March | 24, 2023 | Trailblazers | 80 | Pelicans | 91 |
| March | 27, 2023 | Bulls | 74 | Trailblazers | 123 |
| March | 29, 2023 | Trailblazers | 99 | Grizzlies | 116 |
| March | 31, 2023 | Knicks | 100 | Trailblazers | 82 |
| April | 2, 2023 | Nuggets | 80 | Trailblazers | 105 |
| April | 4, 2023 | Trailblazers | 80 | Nets | 97 |
| April | 6, 2023 | Trailblazers | 112 | Spurs | 130 |
| April | 9, 2023 | Trailblazers | 96 | Thunder | 94 |
| April | 12, 2023 | Jazz | 102 | Trailblazers | 107 |
| April | 14, 2023 | Trailblazers | 88 | Bucks | 116 |
| April | 16, 2023 | Spurs | 104 | Trailblazers | 94 |
| April | 17, 2023 | Trailblazers | 95 | Grizzlies | 87 |
| April | 19, 2023 | Thunder | 100 | Trailblazers | 82 |
| April | 21, 2023 | Trailblazers | 71 | Clippers | 95 |
| April | 22, 2023 | Wolves | 112 | Trailblazers | 117 |
| April | 24, 2023 | Trailblazers | 110 | Jazz | 93 |
| April | 25, 2023 | Trailblazers | 116 | Rockets | 120 |
| April | 27, 2023 | Trailblazers | 86 | Clippers | 89 |
| April | 29, 2023 | Suns | 121 | Trailblazers | 111 |
| May | 1, 2023 | Pistons | 84 | Trailblazers | 85 |
| Post | 1, 2023 | Trailblazers | 79 | Suns | 96 |
| Post | 2, 2023 | Trailblazers | 104 | Suns | 97 |
| Post | 3, 2023 | Suns | 105 | Trailblazers | 106 |
| Post | 4, 2023 | Suns | 94 | Trailblazers | 107 |
| Post | 5, 2023 | Trailblazers | 108 | Suns | 116 |
| Post | 6, 2023 | Suns | 110 | Trailblazers | 105 |
| Post | 7, 2023 | Trailblazers | 94 | Suns | 106 |