| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Wolves | 117 | Spurs | 101 |
| November | 7, 2021 | Spurs | 123 | Trailblazers | 116 |
| November | 9, 2021 | Spurs | 136 | Lakers | 108 |
| November | 12, 2021 | Pacers | 107 | Spurs | 126 |
| November | 16, 2021 | Lakers | 109 | Spurs | 138 |
| November | 18, 2021 | Mavericks | 99 | Spurs | 114 |
| November | 20, 2021 | Spurs | 109 | Suns | 95 |
| November | 23, 2021 | Pelicans | 104 | Spurs | 118 |
| November | 24, 2021 | Magic | 107 | Spurs | 134 |
| November | 27, 2021 | Spurs | 116 | Heat | 118 |
| November | 30, 2021 | Rockets | 84 | Spurs | 117 |
| December | 2, 2021 | Spurs | 100 | Kings | 123 |
| December | 4, 2021 | Spurs | 115 | Suns | 124 |
| December | 5, 2021 | Spurs | 115 | Clippers | 116 |
| December | 8, 2021 | Warriors | 120 | Spurs | 135 |
| December | 9, 2021 | Spurs | 103 | Pelicans | 92 |
| December | 11, 2021 | Grizzlies | 100 | Spurs | 105 |
| December | 14, 2021 | Spurs | 125 | Pacers | 111 |
| December | 15, 2021 | Spurs | 94 | Bucks | 121 |
| December | 17, 2021 | Spurs | 110 | Bulls | 128 |
| December | 19, 2021 | Spurs | 119 | Wolves | 120 |
| December | 21, 2021 | Rockets | 88 | Spurs | 115 |
| December | 23, 2021 | Trailblazers | 94 | Spurs | 118 |
| December | 26, 2021 | Spurs | 113 | Jazz | 109 |
| December | 27, 2021 | Spurs | 103 | Lakers | 126 |
| December | 29, 2021 | Lakers | 93 | Spurs | 122 |
| December | 31, 2021 | Jazz | 114 | Spurs | 127 |
| January | 2, 2022 | Suns | 113 | Spurs | 129 |
| January | 4, 2022 | Clippers | 133 | Spurs | 138 |
| January | 6, 2022 | Bulls | 127 | Spurs | 123 |
| January | 8, 2022 | 76ers | 107 | Spurs | 132 |
| January | 10, 2022 | Spurs | 100 | Magic | 106 |
| January | 12, 2022 | Wolves | 112 | Spurs | 121 |
| January | 13, 2022 | Spurs | 109 | Rockets | 87 |
| January | 16, 2022 | Nuggets | 118 | Spurs | 125 |
| January | 18, 2022 | Spurs | 110 | Nuggets | 103 |
| January | 19, 2022 | Spurs | 123 | Clippers | 127 |
| January | 21, 2022 | Celtics | 85 | Spurs | 142 |
| January | 24, 2022 | Raptors | 100 | Spurs | 115 |
| January | 26, 2022 | Grizzlies | 101 | Spurs | 115 |
| January | 28, 2022 | Spurs | 110 | Pistons | 111 |
| January | 30, 2022 | Spurs | 107 | Grizzlies | 109 |
| January | 31, 2022 | Thunder | 94 | Spurs | 101 |
| February | 2, 2022 | Spurs | 125 | Thunder | 124 |
| February | 5, 2022 | Hornets | 101 | Spurs | 122 |
| February | 7, 2022 | Spurs | 101 | Mavericks | 121 |
| February | 14, 2022 | Spurs | 99 | Wolves | 115 |
| February | 16, 2022 | Clippers | 106 | Spurs | 136 |
| February | 19, 2022 | Spurs | 108 | 76ers | 114 |
| February | 22, 2022 | Spurs | 106 | Pelicans | 109 |
| February | 23, 2022 | Wizards | 103 | Spurs | 125 |
| February | 25, 2022 | Suns | 99 | Spurs | 114 |
| February | 27, 2022 | Nets | 84 | Spurs | 98 |
| March | 2, 2022 | Pelicans | 101 | Spurs | 132 |
| March | 4, 2022 | Spurs | 103 | Kings | 136 |
| March | 6, 2022 | Spurs | 102 | Warriors | 125 |
| March | 7, 2022 | Spurs | 130 | Trailblazers | 122 |
| March | 9, 2022 | Spurs | 127 | Jazz | 111 |
| March | 12, 2022 | Spurs | 105 | Grizzlies | 100 |
| March | 16, 2022 | Spurs | 112 | Raptors | 139 |
| March | 18, 2022 | Spurs | 111 | Knicks | 104 |
| March | 19, 2022 | Spurs | 123 | Nets | 114 |
| March | 21, 2022 | Pistons | 108 | Spurs | 124 |
| March | 24, 2022 | Thunder | 130 | Spurs | 121 |
| March | 26, 2022 | Nuggets | 117 | Spurs | 112 |
| March | 28, 2022 | Spurs | 104 | Hawks | 94 |
| April | 1, 2022 | Bucks | 102 | Spurs | 114 |
| April | 3, 2022 | Spurs | 109 | Mavericks | 94 |
| April | 6, 2022 | Knicks | 87 | Spurs | 107 |
| April | 7, 2022 | Trailblazers | 109 | Spurs | 108 |
| April | 9, 2022 | Warriors | 74 | Spurs | 136 |
| April | 11, 2022 | Heat | 103 | Spurs | 123 |
| April | 13, 2022 | Spurs | 103 | Rockets | 93 |
| April | 15, 2022 | Spurs | 130 | Celtics | 125 |
| April | 17, 2022 | Spurs | 105 | Hornets | 77 |
| April | 19, 2022 | Cavaliers | 110 | Spurs | 126 |
| April | 22, 2022 | Kings | 116 | Spurs | 128 |
| April | 24, 2022 | Hawks | 85 | Spurs | 100 |
| April | 25, 2022 | Spurs | 117 | Nuggets | 120 |
| April | 27, 2022 | Spurs | 125 | Wizards | 110 |
| April | 29, 2022 | Spurs | 138 | Cavaliers | 126 |
| May | 1, 2022 | Mavericks | 106 | Spurs | 117 |
| Post | 1, 2022 | Thunder | 100 | Spurs | 135 |
| Post | 2, 2022 | Thunder | 113 | Spurs | 134 |
| Post | 3, 2022 | Spurs | 122 | Thunder | 103 |
| Post | 4, 2022 | Spurs | 102 | Thunder | 83 |
| Post | 5, 2022 | Thunder | | Spurs | |
| Post | 6, 2022 | Spurs | | Thunder | |
| Post | 7, 2022 | Thunder | | Spurs | |
| Post | 8, 2022 | Grizzlies | 101 | Spurs | 85 |
| Post | 9, 2022 | Grizzlies | 115 | Spurs | 122 |
| Post | 10, 2022 | Spurs | 99 | Grizzlies | 92 |
| Post | 11, 2022 | Spurs | 106 | Grizzlies | 110 |
| Post | 12, 2022 | Grizzlies | 100 | Spurs | 116 |
| Post | 13, 2022 | Spurs | 94 | Grizzlies | 103 |
| Post | 14, 2022 | Grizzlies | 103 | Spurs | 124 |
| Post | 15, 2022 | Jazz | 109 | Spurs | 121 |
| Post | 16, 2022 | Jazz | 98 | Spurs | 131 |
| Post | 17, 2022 | Spurs | 114 | Jazz | 103 |
| Post | 18, 2022 | Spurs | 110 | Jazz | 102 |
| Post | 19, 2022 | Jazz | | Spurs | |
| Post | 20, 2022 | Spurs | | Jazz | |
| Post | 21, 2022 | Jazz | | Spurs | |
| Post | 22, 2022 | Bulls | 107 | Spurs | 110 |
| Post | 23, 2022 | Bulls | 75 | Spurs | 113 |
| Post | 24, 2022 | Spurs | 117 | Bulls | 111 |
| Post | 25, 2022 | Spurs | 79 | Bulls | 112 |
| Post | 26, 2022 | Spurs | 109 | Bulls | 91 |