| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Grizzlies | 114 | Pacers | 120 |
| November | 6, 2021 | Pacers | 97 | Bucks | 95 |
| November | 7, 2021 | Nets | 75 | Pacers | 122 |
| November | 9, 2021 | Pacers | 92 | Wolves | 104 |
| November | 12, 2021 | Pacers | 107 | Spurs | 126 |
| November | 15, 2021 | Pacers | 101 | Cavaliers | 94 |
| November | 18, 2021 | Trailblazers | 112 | Pacers | 118 |
| November | 20, 2021 | Pacers | 103 | Knicks | 96 |
| November | 22, 2021 | Pacers | 98 | Bulls | 106 |
| November | 23, 2021 | Celtics | 105 | Pacers | 103 |
| November | 25, 2021 | Rockets | 76 | Pacers | 94 |
| November | 27, 2021 | 76ers | 94 | Pacers | 92 |
| November | 29, 2021 | Pacers | 82 | Heat | 95 |
| December | 1, 2021 | Pacers | 68 | Rockets | 91 |
| December | 6, 2021 | Heat | 87 | Pacers | 98 |
| December | 7, 2021 | Hawks | 114 | Pacers | 113 |
| December | 9, 2021 | Jazz | 87 | Pacers | 128 |
| December | 12, 2021 | Pacers | 116 | Hornets | 120 |
| December | 14, 2021 | Spurs | 125 | Pacers | 111 |
| December | 17, 2021 | Pacers | 108 | Jazz | 129 |
| December | 18, 2021 | Pacers | 132 | Suns | 122 |
| December | 20, 2021 | Pacers | 118 | Lakers | 117 |
| December | 22, 2021 | Pacers | 105 | Kings | 107 |
| December | 26, 2021 | Bulls | 89 | Pacers | 125 |
| December | 29, 2021 | Pacers | 124 | Magic | 128 |
| December | 30, 2021 | Kings | 109 | Pacers | 120 |
| January | 1, 2022 | Wizards | 99 | Pacers | 106 |
| January | 3, 2022 | Bucks | 117 | Pacers | 130 |
| January | 5, 2022 | Pacers | 122 | 76ers | 112 |
| January | 7, 2022 | Knicks | 86 | Pacers | 116 |
| January | 9, 2022 | Cavaliers | 108 | Pacers | 127 |
| January | 10, 2022 | Pacers | 128 | Raptors | 126 |
| January | 12, 2022 | Pacers | 112 | Nets | 104 |
| January | 14, 2022 | Wizards | 103 | Pacers | 107 |
| January | 16, 2022 | Pacers | 123 | Hawks | 108 |
| January | 18, 2022 | Pistons | 107 | Pacers | 118 |
| January | 21, 2022 | Hawks | 109 | Pacers | 102 |
| January | 25, 2022 | Pacers | 114 | Bulls | 102 |
| January | 27, 2022 | Pacers | 112 | Raptors | 105 |
| January | 29, 2022 | Pacers | 110 | Cavaliers | 108 |
| January | 30, 2022 | Pacers | 117 | Celtics | 97 |
| February | 1, 2022 | Pacers | 110 | Knicks | 98 |
| February | 6, 2022 | Suns | 86 | Pacers | 113 |
| February | 13, 2022 | 76ers | 96 | Pacers | 104 |
| February | 15, 2022 | Mavericks | 95 | Pacers | 104 |
| February | 16, 2022 | Hornets | 84 | Pacers | 132 |
| February | 19, 2022 | Raptors | 112 | Pacers | 119 |
| February | 22, 2022 | Pacers | 103 | Grizzlies | 87 |
| February | 24, 2022 | Warriors | 107 | Pacers | 123 |
| February | 26, 2022 | Pacers | 121 | Wizards | 115 |
| February | 27, 2022 | Pacers | 116 | Magic | 114 |
| March | 1, 2022 | Pacers | 133 | Heat | 96 |
| March | 4, 2022 | Pacers | 102 | Pelicans | 104 |
| March | 5, 2022 | Lakers | 91 | Pacers | 122 |
| March | 7, 2022 | Clippers | 88 | Pacers | 109 |
| March | 9, 2022 | Cavaliers | 80 | Pacers | 94 |
| March | 11, 2022 | Hornets | 105 | Pacers | 108 |
| March | 13, 2022 | Bucks | 110 | Pacers | 125 |
| March | 16, 2022 | Pelicans | 96 | Pacers | 125 |
| March | 17, 2022 | Pacers | 118 | Wizards | 108 |
| March | 19, 2022 | Pacers | 90 | Pistons | 96 |
| March | 21, 2022 | Pacers | 122 | Mavericks | 81 |
| March | 22, 2022 | Wolves | 98 | Pacers | 112 |
| March | 24, 2022 | Magic | 108 | Pacers | 105 |
| March | 27, 2022 | Bulls | 100 | Pacers | 85 |
| March | 29, 2022 | Pacers | 96 | Bucks | 106 |
| April | 1, 2022 | Pacers | 119 | 76ers | 104 |
| April | 3, 2022 | Knicks | 79 | Pacers | 123 |
| April | 5, 2022 | Thunder | 129 | Pacers | 126 |
| April | 7, 2022 | Pacers | 125 | Nuggets | 127 |
| April | 9, 2022 | Pacers | 113 | Trailblazers | 129 |
| April | 10, 2022 | Pacers | 96 | Clippers | 126 |
| April | 12, 2022 | Pacers | 113 | Warriors | 99 |
| April | 15, 2022 | Nuggets | 108 | Pacers | 124 |
| April | 18, 2022 | Pacers | 131 | Thunder | 104 |
| April | 20, 2022 | Pacers | 126 | Celtics | 94 |
| April | 21, 2022 | Magic | 91 | Pacers | 111 |
| April | 23, 2022 | Pistons | 148 | Pacers | 139 |
| April | 25, 2022 | Pacers | 117 | Pistons | 108 |
| April | 27, 2022 | Celtics | 96 | Pacers | 127 |
| April | 29, 2022 | Nets | 79 | Pacers | 110 |
| May | 1, 2022 | Pacers | 122 | Hawks | 115 |
| Post | 1, 2022 | Bucks | 117 | Pacers | 111 |
| Post | 2, 2022 | Bucks | 103 | Pacers | 94 |
| Post | 3, 2022 | Pacers | 96 | Bucks | 108 |
| Post | 4, 2022 | Pacers | 88 | Bucks | 109 |
| Post | 5, 2022 | Bucks | | Pacers | |
| Post | 6, 2022 | Pacers | | Bucks | |
| Post | 7, 2022 | Bucks | | Pacers | |