| month | day | visitor | score | home | score |
|---|
| November | 5, 2021 | Lakers | 116 | Trailblazers | 111 |
| November | 7, 2021 | Rockets | 110 | Lakers | 123 |
| November | 9, 2021 | Spurs | 136 | Lakers | 108 |
| November | 12, 2021 | Lakers | 124 | Suns | 116 |
| November | 13, 2021 | Nuggets | 113 | Lakers | 114 |
| November | 16, 2021 | Lakers | 109 | Spurs | 138 |
| November | 18, 2021 | Lakers | 86 | Wolves | 113 |
| November | 20, 2021 | Mavericks | 108 | Lakers | 99 |
| November | 23, 2021 | Lakers | 119 | Trailblazers | 109 |
| November | 24, 2021 | Raptors | 123 | Lakers | 121 |
| November | 27, 2021 | Wolves | 117 | Lakers | 104 |
| November | 30, 2021 | Lakers | 123 | Kings | 108 |
| December | 1, 2021 | Hawks | 112 | Lakers | 122 |
| December | 4, 2021 | Trailblazers | 109 | Lakers | 111 |
| December | 7, 2021 | Lakers | 121 | Magic | 133 |
| December | 8, 2021 | Lakers | 106 | Heat | 117 |
| December | 12, 2021 | Lakers | 119 | Cavaliers | 117 |
| December | 14, 2021 | Jazz | 127 | Lakers | 105 |
| December | 16, 2021 | Magic | 117 | Lakers | 113 |
| December | 18, 2021 | Lakers | 86 | Nuggets | 119 |
| December | 20, 2021 | Pacers | 118 | Lakers | 117 |
| December | 21, 2021 | Mavericks | 121 | Lakers | 114 |
| December | 23, 2021 | Suns | 124 | Lakers | 100 |
| December | 27, 2021 | Spurs | 103 | Lakers | 126 |
| December | 29, 2021 | Lakers | 93 | Spurs | 122 |
| December | 30, 2021 | Lakers | 122 | Grizzlies | 130 |
| January | 1, 2022 | Heat | 111 | Lakers | 109 |
| January | 4, 2022 | Lakers | 124 | Rockets | 127 |
| January | 6, 2022 | Lakers | 126 | Hornets | 134 |
| January | 7, 2022 | Lakers | 96 | Wizards | 145 |
| January | 9, 2022 | Lakers | 106 | Nets | 108 |
| January | 12, 2022 | Pelicans | 91 | Lakers | 113 |
| January | 14, 2022 | Grizzlies | 122 | Lakers | 127 |
| January | 15, 2022 | Lakers | 122 | Warriors | 136 |
| January | 17, 2022 | Lakers | 130 | Kings | 110 |
| January | 18, 2022 | Clippers | 116 | Lakers | 120 |
| January | 20, 2022 | Kings | 116 | Lakers | 132 |
| January | 23, 2022 | Thunder | 127 | Lakers | 113 |
| January | 25, 2022 | Knicks | 97 | Lakers | 117 |
| January | 27, 2022 | Lakers | 131 | Wolves | 126 |
| January | 28, 2022 | Lakers | 108 | Mavericks | 109 |
| January | 30, 2022 | Pistons | 142 | Lakers | 136 |
| February | 1, 2022 | Lakers | 108 | Jazz | 104 |
| February | 4, 2022 | Cavaliers | 119 | Lakers | 140 |
| February | 6, 2022 | Bulls | 118 | Lakers | 107 |
| February | 13, 2022 | Lakers | 131 | Thunder | 127 |
| February | 15, 2022 | Lakers | 103 | Rockets | 137 |
| February | 17, 2022 | Warriors | 116 | Lakers | 128 |
| February | 20, 2022 | Wolves | 103 | Lakers | 122 |
| February | 23, 2022 | Suns | 124 | Lakers | 126 |
| February | 25, 2022 | 76ers | 121 | Lakers | 133 |
| February | 27, 2022 | Lakers | 87 | Clippers | 137 |
| March | 2, 2022 | Lakers | 123 | Warriors | 129 |
| March | 5, 2022 | Lakers | 91 | Pacers | 122 |
| March | 7, 2022 | Lakers | 129 | Celtics | 132 |
| March | 10, 2022 | Lakers | 112 | 76ers | 119 |
| March | 12, 2022 | Lakers | 120 | Hawks | 125 |
| March | 15, 2022 | Rockets | 124 | Lakers | 127 |
| March | 17, 2022 | Lakers | 116 | Pelicans | 125 |
| March | 19, 2022 | Lakers | 121 | Grizzlies | 126 |
| March | 21, 2022 | Pelicans | 124 | Lakers | 120 |
| March | 23, 2022 | Bucks | 127 | Lakers | 111 |
| March | 24, 2022 | Lakers | 115 | Suns | 131 |
| March | 26, 2022 | Clippers | 128 | Lakers | 107 |
| March | 28, 2022 | Nuggets | 122 | Lakers | 118 |
| March | 31, 2022 | Celtics | 98 | Lakers | 119 |
| April | 3, 2022 | Lakers | 112 | Bulls | 119 |
| April | 5, 2022 | Lakers | 126 | Raptors | 117 |
| April | 6, 2022 | Lakers | 115 | Pistons | 120 |
| April | 8, 2022 | Lakers | 112 | Knicks | 104 |
| April | 10, 2022 | Lakers | 107 | Bucks | 143 |
| April | 13, 2022 | Nets | 123 | Lakers | 124 |
| April | 15, 2022 | Kings | 133 | Lakers | 126 |
| April | 17, 2022 | Wizards | 129 | Lakers | 126 |
| April | 18, 2022 | Lakers | 108 | Jazz | 128 |
| April | 20, 2022 | Hornets | 105 | Lakers | 118 |
| April | 22, 2022 | Lakers | 118 | Pelicans | 121 |
| April | 24, 2022 | Lakers | 118 | Thunder | 120 |
| April | 26, 2022 | Warriors | 96 | Lakers | 123 |
| April | 27, 2022 | Lakers | 87 | Clippers | 126 |
| April | 29, 2022 | Jazz | 122 | Lakers | 101 |
| April | 30, 2022 | Trailblazers | 129 | Lakers | 120 |