| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Heat | 112 | Magic | 122 |
| November | 5, 2021 | Heat | 85 | Wizards | 98 |
| November | 7, 2021 | Hornets | 98 | Heat | 94 |
| November | 11, 2021 | Knicks | 78 | Heat | 77 |
| November | 16, 2021 | Trailblazers | 99 | Heat | 110 |
| November | 18, 2021 | Kings | 106 | Heat | 108 |
| November | 19, 2021 | Heat | 100 | Hornets | 104 |
| November | 23, 2021 | Heat | 81 | Hawks | 105 |
| November | 25, 2021 | Heat | 94 | Pistons | 78 |
| November | 27, 2021 | Spurs | 116 | Heat | 118 |
| November | 29, 2021 | Pacers | 82 | Heat | 95 |
| November | 30, 2021 | Wizards | 82 | Heat | 86 |
| December | 2, 2021 | 76ers | 87 | Heat | 90 |
| December | 4, 2021 | Heat | 98 | Nets | 85 |
| December | 6, 2021 | Heat | 87 | Pacers | 98 |
| December | 8, 2021 | Lakers | 106 | Heat | 117 |
| December | 10, 2021 | Nets | 84 | Heat | 87 |
| December | 14, 2021 | Heat | 99 | Bulls | 107 |
| December | 16, 2021 | Heat | 92 | Raptors | 104 |
| December | 18, 2021 | Hawks | 115 | Heat | 78 |
| December | 21, 2021 | Pelicans | 96 | Heat | 107 |
| December | 23, 2021 | Jazz | 112 | Heat | 110 |
| December | 26, 2021 | Magic | 122 | Heat | 124 |
| December | 29, 2021 | Heat | 102 | Suns | 93 |
| December | 30, 2021 | Heat | 95 | Clippers | 100 |
| January | 1, 2022 | Heat | 111 | Lakers | 109 |
| January | 3, 2022 | Heat | 114 | Jazz | 109 |
| January | 5, 2022 | Heat | 71 | Grizzlies | 82 |
| January | 7, 2022 | Heat | 111 | Pelicans | 95 |
| January | 11, 2022 | Rockets | 100 | Heat | 102 |
| January | 13, 2022 | Bucks | 108 | Heat | 114 |
| January | 14, 2022 | Heat | 104 | Magic | 100 |
| January | 16, 2022 | Raptors | 121 | Heat | 97 |
| January | 18, 2022 | Cavaliers | 94 | Heat | 114 |
| January | 20, 2022 | Wolves | 82 | Heat | 79 |
| January | 23, 2022 | Heat | 120 | Cavaliers | 114 |
| January | 25, 2022 | Wizards | 91 | Heat | 83 |
| January | 27, 2022 | Heat | 83 | Hawks | 99 |
| January | 29, 2022 | Nuggets | 93 | Heat | 99 |
| January | 31, 2022 | Celtics | 101 | Heat | 106 |
| February | 2, 2022 | Grizzlies | 96 | Heat | 98 |
| February | 6, 2022 | Heat | 108 | Bucks | 117 |
| February | 14, 2022 | Heat | 83 | Pistons | 102 |
| February | 15, 2022 | Heat | 112 | Bulls | 117 |
| February | 17, 2022 | Heat | 116 | Celtics | 115 |
| February | 19, 2022 | Clippers | 122 | Heat | 99 |
| February | 21, 2022 | Heat | 109 | Cavaliers | 112 |
| February | 23, 2022 | Heat | 82 | Knicks | 103 |
| February | 26, 2022 | Bulls | 100 | Heat | 83 |
| February | 28, 2022 | Thunder | 88 | Heat | 123 |
| March | 1, 2022 | Pacers | 133 | Heat | 96 |
| March | 5, 2022 | Heat | 86 | Trailblazers | 91 |
| March | 8, 2022 | Heat | 127 | Kings | 136 |
| March | 10, 2022 | Heat | 122 | Warriors | 125 |
| March | 11, 2022 | Heat | 92 | Nuggets | 99 |
| March | 13, 2022 | Heat | 106 | Mavericks | 115 |
| March | 15, 2022 | Heat | 105 | 76ers | 118 |
| March | 17, 2022 | Pistons | 96 | Heat | 85 |
| March | 19, 2022 | Suns | 88 | Heat | 115 |
| March | 21, 2022 | Warriors | 109 | Heat | 111 |
| March | 22, 2022 | Heat | 101 | Rockets | 103 |
| March | 24, 2022 | Nets | 104 | Heat | 101 |
| March | 26, 2022 | Hawks | 76 | Heat | 80 |
| March | 28, 2022 | Heat | 67 | Hornets | 98 |
| March | 30, 2022 | Cavaliers | 118 | Heat | 109 |
| April | 1, 2022 | Raptors | 126 | Heat | 120 |
| April | 4, 2022 | Pistons | 76 | Heat | 92 |
| April | 6, 2022 | Bucks | 125 | Heat | 107 |
| April | 8, 2022 | Hornets | 68 | Heat | 94 |
| April | 9, 2022 | Heat | 112 | Thunder | 119 |
| April | 11, 2022 | Heat | 103 | Spurs | 123 |
| April | 13, 2022 | Heat | 82 | Bucks | 114 |
| April | 14, 2022 | Heat | 89 | Wizards | 109 |
| April | 17, 2022 | Magic | 111 | Heat | 125 |
| April | 19, 2022 | Mavericks | 106 | Heat | 99 |
| April | 21, 2022 | Heat | 79 | Knicks | 97 |
| April | 23, 2022 | Heat | 94 | Celtics | 108 |
| April | 25, 2022 | Celtics | 104 | Heat | 109 |
| April | 27, 2022 | Heat | 93 | Wolves | 103 |
| April | 29, 2022 | Heat | 108 | Raptors | 122 |
| April | 30, 2022 | 76ers | 95 | Heat | 112 |
| May | 1, 2022 | Heat | 99 | Nets | 85 |