| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Rockets | 106 | Spurs | 109 |
| November | 5, 2021 | Spurs | 103 | Pelicans | 109 |
| November | 7, 2021 | Pacers | 114 | Spurs | 116 |
| November | 9, 2021 | Wolves | 99 | Spurs | 124 |
| November | 12, 2021 | Spurs | 142 | Thunder | 105 |
| November | 14, 2021 | Spurs | 137 | Magic | 112 |
| November | 17, 2021 | Spurs | 100 | Bulls | 97 |
| November | 19, 2021 | Lakers | 85 | Spurs | 115 |
| November | 20, 2021 | Spurs | 94 | Clippers | 108 |
| November | 23, 2021 | Nets | 92 | Spurs | 117 |
| November | 25, 2021 | Spurs | 108 | Wolves | 122 |
| November | 27, 2021 | Trailblazers | 82 | Spurs | 108 |
| November | 30, 2021 | Spurs | 104 | Kings | 110 |
| December | 1, 2021 | Nuggets | 102 | Spurs | 127 |
| December | 4, 2021 | Spurs | 97 | 76ers | 65 |
| December | 7, 2021 | Spurs | 97 | Wizards | 80 |
| December | 9, 2021 | Spurs | 98 | Knicks | 104 |
| December | 12, 2021 | Spurs | 112 | Rockets | 106 |
| December | 14, 2021 | Suns | 106 | Spurs | 129 |
| December | 16, 2021 | Pistons | 98 | Spurs | 116 |
| December | 18, 2021 | Spurs | 101 | Warriors | 115 |
| December | 21, 2021 | Spurs | 114 | Mavericks | 111 |
| December | 25, 2021 | Spurs | 113 | Lakers | 105 |
| December | 26, 2021 | Spurs | 107 | Jazz | 118 |
| December | 28, 2021 | Bucks | 104 | Spurs | 96 |
| December | 31, 2021 | Spurs | 115 | Clippers | 113 |
| January | 2, 2022 | Cavaliers | 114 | Spurs | 136 |
| January | 5, 2022 | Spurs | 95 | Hawks | 96 |
| January | 8, 2022 | Grizzlies | 107 | Spurs | 102 |
| January | 10, 2022 | Spurs | 121 | Warriors | 107 |
| January | 11, 2022 | Rockets | 96 | Spurs | 92 |
| January | 13, 2022 | Spurs | 101 | Bucks | 123 |
| January | 15, 2022 | Spurs | 138 | Celtics | 111 |
| January | 17, 2022 | Jazz | 108 | Spurs | 124 |
| January | 18, 2022 | Spurs | 104 | Suns | 130 |
| January | 20, 2022 | Thunder | 110 | Spurs | 131 |
| January | 21, 2022 | Knicks | 106 | Spurs | 128 |
| January | 24, 2022 | Spurs | 123 | Lakers | 87 |
| January | 26, 2022 | Magic | 106 | Spurs | 119 |
| January | 29, 2022 | Suns | 101 | Spurs | 116 |
| February | 1, 2022 | Spurs | 109 | Trailblazers | 96 |
| February | 4, 2022 | 76ers | 91 | Spurs | 107 |
| February | 7, 2022 | Spurs | 109 | Wolves | 97 |
| February | 14, 2022 | Hawks | 101 | Spurs | 115 |
| February | 17, 2022 | Spurs | 106 | Kings | 96 |
| February | 19, 2022 | Pelicans | 93 | Spurs | 118 |
| February | 21, 2022 | Spurs | 101 | Heat | 91 |
| February | 24, 2022 | Spurs | 120 | Nets | 109 |
| February | 27, 2022 | Spurs | 98 | Rockets | 102 |
| March | 2, 2022 | Kings | 101 | Spurs | 105 |
| March | 4, 2022 | Spurs | 106 | Raptors | 113 |
| March | 5, 2022 | Celtics | 106 | Spurs | 129 |
| March | 7, 2022 | Spurs | 138 | Suns | 131 |
| March | 9, 2022 | Bulls | 95 | Spurs | 109 |
| March | 11, 2022 | Spurs | 108 | Nuggets | 93 |
| March | 12, 2022 | Grizzlies | 79 | Spurs | 98 |
| March | 14, 2022 | Spurs | 74 | Pistons | 104 |
| March | 15, 2022 | Lakers | 90 | Spurs | 116 |
| March | 18, 2022 | Thunder | 93 | Spurs | 103 |
| March | 20, 2022 | Wolves | 111 | Spurs | 114 |
| March | 23, 2022 | Spurs | 102 | Jazz | 120 |
| March | 24, 2022 | Raptors | 96 | Spurs | 116 |
| March | 26, 2022 | Wizards | 102 | Spurs | 128 |
| March | 27, 2022 | Spurs | 120 | Hornets | 121 |
| March | 29, 2022 | Pelicans | 104 | Spurs | 134 |
| March | 31, 2022 | Spurs | 126 | Pacers | 142 |
| April | 2, 2022 | Spurs | 121 | Cavaliers | 107 |
| April | 4, 2022 | Heat | 107 | Spurs | 117 |
| April | 6, 2022 | Trailblazers | 84 | Spurs | 109 |
| April | 9, 2022 | Clippers | 116 | Spurs | 134 |
| April | 10, 2022 | Nuggets | 100 | Spurs | 140 |
| April | 13, 2022 | Mavericks | 98 | Spurs | 114 |
| April | 16, 2022 | Spurs | 92 | Trailblazers | 113 |
| April | 18, 2022 | Warriors | 117 | Spurs | 140 |
| April | 19, 2022 | Hornets | 115 | Spurs | 119 |
| April | 21, 2022 | Spurs | 123 | Grizzlies | 130 |
| April | 22, 2022 | Jazz | 109 | Spurs | 124 |
| April | 24, 2022 | Kings | 94 | Spurs | 107 |
| April | 26, 2022 | Spurs | 109 | Pelicans | 102 |
| April | 29, 2022 | Spurs | 134 | Mavericks | 104 |
| April | 30, 2022 | Spurs | 117 | Grizzlies | 103 |
| May | 1, 2022 | Clippers | 107 | Spurs | 136 |
| Post | 1, 2022 | Clippers | 126 | Spurs | 129 |
| Post | 2, 2022 | Clippers | 90 | Spurs | 134 |
| Post | 3, 2022 | Spurs | 117 | Clippers | 105 |
| Post | 4, 2022 | Spurs | 120 | Clippers | 103 |
| Post | 5, 2022 | Clippers | | Spurs | |
| Post | 6, 2022 | Spurs | | Clippers | |
| Post | 7, 2022 | Clippers | | Spurs | |
| Post | 8, 2022 | Grizzlies | 122 | Spurs | 138 |
| Post | 9, 2022 | Grizzlies | 111 | Spurs | 131 |
| Post | 10, 2022 | Spurs | 145 | Grizzlies | 122 |
| Post | 11, 2022 | Spurs | 89 | Grizzlies | 133 |
| Post | 12, 2022 | Grizzlies | 124 | Spurs | 112 |
| Post | 13, 2022 | Spurs | 98 | Grizzlies | 124 |
| Post | 14, 2022 | Grizzlies | 114 | Spurs | 96 |