| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Clippers | 82 | Lakers | 123 |
| November | 3, 2021 | Nuggets | 99 | Clippers | 116 |
| November | 5, 2021 | Clippers | 120 | Thunder | 108 |
| November | 8, 2021 | Bulls | 110 | Clippers | 125 |
| November | 10, 2021 | Clippers | 123 | Suns | 108 |
| November | 13, 2021 | Clippers | 85 | Hawks | 101 |
| November | 14, 2021 | Clippers | 96 | Bucks | 122 |
| November | 17, 2021 | Clippers | 95 | Wizards | 123 |
| November | 20, 2021 | Spurs | 94 | Clippers | 108 |
| November | 22, 2021 | Knicks | 94 | Clippers | 112 |
| November | 24, 2021 | Clippers | 93 | Grizzlies | 123 |
| November | 26, 2021 | Pelicans | 93 | Clippers | 107 |
| November | 28, 2021 | Jazz | 96 | Clippers | 110 |
| November | 30, 2021 | Clippers | 101 | Hornets | 121 |
| December | 2, 2021 | Clippers | 128 | Celtics | 109 |
| December | 5, 2021 | Kings | 111 | Clippers | 128 |
| December | 8, 2021 | Clippers | 83 | Rockets | 111 |
| December | 10, 2021 | Cavaliers | 121 | Clippers | 118 |
| December | 13, 2021 | Clippers | 105 | Trailblazers | 109 |
| December | 15, 2021 | Suns | 108 | Clippers | 131 |
| December | 18, 2021 | Clippers | 82 | 76ers | 94 |
| December | 19, 2021 | Clippers | 106 | Nets | 134 |
| December | 21, 2021 | Clippers | 89 | Heat | 106 |
| December | 23, 2021 | Jazz | 114 | Clippers | 121 |
| December | 26, 2021 | Clippers | 118 | Nuggets | 107 |
| December | 29, 2021 | Clippers | 85 | Wolves | 126 |
| December | 31, 2021 | Spurs | 115 | Clippers | 113 |
| January | 2, 2022 | Nuggets | 104 | Clippers | 132 |
| January | 5, 2022 | Clippers | 90 | Trailblazers | 74 |
| January | 6, 2022 | Thunder | 117 | Clippers | 142 |
| January | 8, 2022 | Raptors | 120 | Clippers | 101 |
| January | 10, 2022 | Wolves | 122 | Clippers | 117 |
| January | 11, 2022 | Clippers | 84 | Kings | 109 |
| January | 13, 2022 | Pelicans | 109 | Clippers | 100 |
| January | 15, 2022 | Clippers | 93 | Knicks | 77 |
| January | 17, 2022 | Clippers | 128 | Magic | 117 |
| January | 20, 2022 | Clippers | 94 | Pistons | 96 |
| January | 23, 2022 | Clippers | 99 | Mavericks | 114 |
| January | 24, 2022 | Warriors | 122 | Clippers | 128 |
| January | 26, 2022 | Clippers | 124 | Kings | 96 |
| January | 29, 2022 | Bucks | 120 | Clippers | 110 |
| January | 31, 2022 | Clippers | 94 | Rockets | 114 |
| February | 2, 2022 | Clippers | 124 | Jazz | 111 |
| February | 5, 2022 | Lakers | 128 | Clippers | 118 |
| February | 7, 2022 | Clippers | 94 | Warriors | 144 |
| February | 14, 2022 | Grizzlies | 115 | Clippers | 137 |
| February | 15, 2022 | Heat | 98 | Clippers | 90 |
| February | 17, 2022 | 76ers | 84 | Clippers | 105 |
| February | 20, 2022 | Clippers | 123 | Suns | 133 |
| February | 22, 2022 | Hornets | 88 | Clippers | 98 |
| February | 25, 2022 | Thunder | 136 | Clippers | 117 |
| February | 27, 2022 | Clippers | 123 | Warriors | 116 |
| March | 1, 2022 | Wolves | 137 | Clippers | 111 |
| March | 2, 2022 | Rockets | 108 | Clippers | 102 |
| March | 4, 2022 | Clippers | 103 | Bulls | 107 |
| March | 6, 2022 | Clippers | 106 | Pacers | 108 |
| March | 8, 2022 | Wizards | 104 | Clippers | 102 |
| March | 10, 2022 | Clippers | 130 | Wolves | 134 |
| March | 13, 2022 | Nets | 95 | Clippers | 136 |
| March | 15, 2022 | Clippers | 101 | Cavaliers | 132 |
| March | 18, 2022 | Mavericks | 116 | Clippers | 127 |
| March | 21, 2022 | Clippers | 120 | Raptors | 106 |
| March | 24, 2022 | Clippers | 125 | Thunder | 104 |
| March | 27, 2022 | Grizzlies | 118 | Clippers | 109 |
| March | 30, 2022 | Celtics | 112 | Clippers | 105 |
| April | 1, 2022 | Hawks | 91 | Clippers | 105 |
| April | 3, 2022 | Magic | 120 | Clippers | 112 |
| April | 5, 2022 | Pistons | 110 | Clippers | 112 |
| April | 9, 2022 | Clippers | 116 | Spurs | 134 |
| April | 11, 2022 | Kings | 105 | Clippers | 127 |
| April | 14, 2022 | Suns | 108 | Clippers | 97 |
| April | 16, 2022 | Clippers | 106 | Grizzlies | 119 |
| April | 17, 2022 | Clippers | 93 | Mavericks | 114 |
| April | 19, 2022 | Clippers | 118 | Jazz | 114 |
| April | 21, 2022 | Trailblazers | 101 | Clippers | 97 |
| April | 22, 2022 | Clippers | 124 | Nuggets | 98 |
| April | 24, 2022 | Lakers | 116 | Clippers | 121 |
| April | 25, 2022 | Warriors | 118 | Clippers | 109 |
| April | 27, 2022 | Trailblazers | 96 | Clippers | 99 |
| April | 28, 2022 | Pacers | 128 | Clippers | 116 |
| April | 30, 2022 | Clippers | 110 | Pelicans | 103 |
| May | 1, 2022 | Clippers | 107 | Spurs | 136 |
| Post | 1, 2022 | Clippers | 126 | Spurs | 129 |
| Post | 2, 2022 | Clippers | 90 | Spurs | 134 |
| Post | 3, 2022 | Spurs | 117 | Clippers | 105 |
| Post | 4, 2022 | Spurs | 120 | Clippers | 103 |
| Post | 5, 2022 | Clippers | | Spurs | |
| Post | 6, 2022 | Spurs | | Clippers | |
| Post | 7, 2022 | Clippers | | Spurs | |