| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Bucks | 111 | 76ers | 123 |
| November | 5, 2021 | 76ers | 87 | Wizards | 92 |
| November | 7, 2021 | Heat | 97 | 76ers | 96 |
| November | 10, 2021 | 76ers | 68 | Pacers | 113 |
| November | 12, 2021 | 76ers | 69 | Pistons | 103 |
| November | 15, 2021 | Knicks | 96 | 76ers | 88 |
| November | 16, 2021 | Cavaliers | 107 | 76ers | 99 |
| November | 19, 2021 | 76ers | 89 | Hornets | 84 |
| November | 21, 2021 | 76ers | 87 | Magic | 98 |
| November | 24, 2021 | Nuggets | 88 | 76ers | 95 |
| November | 27, 2021 | 76ers | 63 | Mavericks | 99 |
| November | 30, 2021 | 76ers | 75 | Grizzlies | 103 |
| December | 2, 2021 | Pelicans | 92 | 76ers | 86 |
| December | 4, 2021 | Spurs | 97 | 76ers | 65 |
| December | 6, 2021 | Trailblazers | 77 | 76ers | 94 |
| December | 8, 2021 | 76ers | 73 | Pacers | 119 |
| December | 10, 2021 | Kings | 96 | 76ers | 103 |
| December | 12, 2021 | Thunder | 91 | 76ers | 94 |
| December | 14, 2021 | 76ers | 68 | Nets | 97 |
| December | 15, 2021 | Grizzlies | 99 | 76ers | 90 |
| December | 17, 2021 | Rockets | 87 | 76ers | 83 |
| December | 18, 2021 | Clippers | 82 | 76ers | 94 |
| December | 21, 2021 | Wolves | 92 | 76ers | 73 |
| December | 22, 2021 | Warriors | 99 | 76ers | 83 |
| December | 25, 2021 | Celtics | 95 | 76ers | 80 |
| December | 27, 2021 | 76ers | 90 | Bulls | 95 |
| December | 30, 2021 | 76ers | 69 | Raptors | 106 |
| January | 1, 2022 | Hornets | 77 | 76ers | 94 |
| January | 3, 2022 | Jazz | 98 | 76ers | 66 |
| January | 5, 2022 | 76ers | 81 | Pelicans | 85 |
| January | 8, 2022 | 76ers | 88 | Nuggets | 80 |
| January | 10, 2022 | Bulls | 104 | 76ers | 77 |
| January | 12, 2022 | 76ers | 83 | Thunder | 96 |
| January | 13, 2022 | 76ers | 89 | Kings | 106 |
| January | 15, 2022 | Suns | 88 | 76ers | 94 |
| January | 18, 2022 | 76ers | 99 | Celtics | 84 |
| January | 19, 2022 | Lakers | 84 | 76ers | 101 |
| January | 21, 2022 | 76ers | 84 | Warriors | 107 |
| January | 24, 2022 | 76ers | 65 | Hawks | 93 |
| January | 26, 2022 | Raptors | 95 | 76ers | 77 |
| January | 29, 2022 | 76ers | 93 | Cavaliers | 114 |
| January | 31, 2022 | Magic | 84 | 76ers | 88 |
| February | 2, 2022 | Wizards | 102 | 76ers | 95 |
| February | 4, 2022 | 76ers | 91 | Spurs | 107 |
| February | 5, 2022 | Mavericks | 92 | 76ers | 79 |
| February | 13, 2022 | Pacers | 114 | 76ers | 98 |
| February | 14, 2022 | Nets | 95 | 76ers | 106 |
| February | 17, 2022 | 76ers | 84 | Clippers | 105 |
| February | 18, 2022 | 76ers | 90 | Trailblazers | 118 |
| February | 20, 2022 | 76ers | 98 | Jazz | 92 |
| February | 23, 2022 | Pacers | 104 | 76ers | 87 |
| February | 25, 2022 | Heat | 94 | 76ers | 92 |
| February | 27, 2022 | 76ers | 100 | Knicks | 105 |
| March | 1, 2022 | Pistons | 104 | 76ers | 90 |
| March | 4, 2022 | Bucks | 105 | 76ers | 75 |
| March | 6, 2022 | 76ers | 72 | Wolves | 105 |
| March | 9, 2022 | Celtics | 79 | 76ers | 89 |
| March | 11, 2022 | 76ers | 86 | Raptors | 116 |
| March | 12, 2022 | 76ers | 78 | Cavaliers | 116 |
| March | 15, 2022 | Wizards | 84 | 76ers | 88 |
| March | 17, 2022 | 76ers | 63 | Hawks | 100 |
| March | 18, 2022 | 76ers | 102 | Wizards | 96 |
| March | 20, 2022 | Bulls | 106 | 76ers | 68 |
| March | 22, 2022 | 76ers | 98 | Lakers | 119 |
| March | 25, 2022 | Pistons | 105 | 76ers | 88 |
| March | 27, 2022 | Hawks | 113 | 76ers | 120 |
| March | 30, 2022 | 76ers | 83 | Rockets | 95 |
| April | 2, 2022 | Nets | 77 | 76ers | 79 |
| April | 5, 2022 | 76ers | 95 | Heat | 80 |
| April | 7, 2022 | 76ers | 93 | Hornets | 86 |
| April | 10, 2022 | 76ers | 80 | Bulls | 101 |
| April | 12, 2022 | Raptors | 102 | 76ers | 78 |
| April | 14, 2022 | 76ers | 88 | Celtics | 99 |
| April | 16, 2022 | 76ers | 88 | Heat | 98 |
| April | 18, 2022 | 76ers | 78 | Knicks | 96 |
| April | 19, 2022 | Cavaliers | 87 | 76ers | 97 |
| April | 21, 2022 | 76ers | 89 | Bucks | 126 |
| April | 24, 2022 | 76ers | 80 | Suns | 98 |
| April | 26, 2022 | Magic | 121 | 76ers | 127 |
| April | 27, 2022 | 76ers | 86 | Nets | 81 |
| April | 30, 2022 | 76ers | 80 | Pistons | 92 |
| May | 1, 2022 | Hawks | 77 | 76ers | 101 |