| month | day | visitor | score | home | score |
|---|
| November | 5, 2020 | Lakers | 119 | Trailblazers | 112 |
| November | 7, 2020 | Spurs | 145 | Trailblazers | 123 |
| November | 9, 2020 | Wizards | 108 | Trailblazers | 126 |
| November | 13, 2020 | Trailblazers | 105 | Magic | 113 |
| November | 16, 2020 | Trailblazers | 125 | Heat | 128 |
| November | 18, 2020 | Trailblazers | 89 | Pacers | 112 |
| November | 19, 2020 | Trailblazers | 96 | Rockets | 109 |
| November | 21, 2020 | Pelicans | 98 | Trailblazers | 109 |
| November | 23, 2020 | Lakers | 107 | Trailblazers | 104 |
| November | 24, 2020 | Wolves | 101 | Trailblazers | 98 |
| November | 26, 2020 | Bucks | 121 | Trailblazers | 103 |
| November | 28, 2020 | Clippers | 134 | Trailblazers | 129 |
| December | 1, 2020 | Celtics | 101 | Trailblazers | 106 |
| December | 4, 2020 | Trailblazers | 110 | Lakers | 139 |
| December | 6, 2020 | Trailblazers | 99 | Wolves | 137 |
| December | 8, 2020 | Trailblazers | 103 | Wizards | 123 |
| December | 10, 2020 | Trailblazers | 127 | Knicks | 138 |
| December | 11, 2020 | Trailblazers | 113 | Bucks | 121 |
| December | 14, 2020 | Trailblazers | 126 | Warriors | 119 |
| December | 16, 2020 | Clippers | 110 | Trailblazers | 122 |
| December | 19, 2020 | Magic | 145 | Trailblazers | 130 |
| December | 21, 2020 | Nuggets | 104 | Trailblazers | 112 |
| December | 23, 2020 | Trailblazers | 131 | Spurs | 139 |
| December | 26, 2020 | Trailblazers | 112 | Mavericks | 117 |
| December | 28, 2020 | Suns | 105 | Trailblazers | 118 |
| December | 30, 2020 | Wolves | 116 | Trailblazers | 114 |
| January | 2, 2021 | Trailblazers | 77 | Rockets | 124 |
| January | 3, 2021 | Trailblazers | 122 | Grizzlies | 125 |
| January | 5, 2021 | Raptors | 88 | Trailblazers | 103 |
| January | 8, 2021 | Trailblazers | 108 | Clippers | 116 |
| January | 11, 2021 | Grizzlies | 113 | Trailblazers | 148 |
| January | 12, 2021 | Jazz | 132 | Trailblazers | 96 |
| January | 14, 2021 | Mavericks | 128 | Trailblazers | 121 |
| January | 15, 2021 | Trailblazers | 93 | Jazz | 123 |
| January | 17, 2021 | Trailblazers | 119 | Warriors | 110 |
| January | 19, 2021 | Warriors | 116 | Trailblazers | 132 |
| January | 20, 2021 | 76ers | 121 | Trailblazers | 112 |
| January | 22, 2021 | Trailblazers | 98 | Kings | 110 |
| January | 25, 2021 | Thunder | 114 | Trailblazers | 138 |
| January | 26, 2021 | Rockets | 101 | Trailblazers | 105 |
| January | 28, 2021 | Knicks | 108 | Trailblazers | 110 |
| January | 30, 2021 | Bulls | 98 | Trailblazers | 101 |
| February | 1, 2021 | Hornets | 108 | Trailblazers | 114 |
| February | 4, 2021 | Trailblazers | 119 | Nuggets | 133 |
| February | 5, 2021 | Trailblazers | 107 | Kings | 112 |
| February | 7, 2021 | Cavaliers | 106 | Trailblazers | 118 |
| February | 14, 2021 | Pelicans | 98 | Trailblazers | 124 |
| February | 17, 2021 | Trailblazers | 121 | Jazz | 108 |
| February | 18, 2021 | Trailblazers | 119 | Thunder | 118 |
| February | 20, 2021 | Trailblazers | 77 | Suns | 97 |
| February | 22, 2021 | Hawks | 91 | Trailblazers | 115 |
| February | 26, 2021 | Jazz | 108 | Trailblazers | 112 |
| March | 5, 2021 | Heat | 85 | Trailblazers | 105 |
| March | 7, 2021 | Spurs | 113 | Trailblazers | 125 |
| March | 10, 2021 | Trailblazers | 106 | Mavericks | 124 |
| March | 11, 2021 | Trailblazers | 134 | Thunder | 100 |
| March | 13, 2021 | Warriors | 114 | Trailblazers | 111 |
| March | 15, 2021 | Trailblazers | 113 | Nets | 101 |
| March | 17, 2021 | Trailblazers | 104 | 76ers | 126 |
| March | 19, 2021 | Trailblazers | 113 | Cavaliers | 129 |
| March | 21, 2021 | Trailblazers | 121 | Celtics | 124 |
| March | 23, 2021 | Trailblazers | 105 | Raptors | 112 |
| March | 25, 2021 | Trailblazers | 98 | Hornets | 104 |
| March | 27, 2021 | Trailblazers | 119 | Grizzlies | 115 |
| March | 29, 2021 | Thunder | 132 | Trailblazers | 123 |
| March | 31, 2021 | Suns | 112 | Trailblazers | 116 |
| April | 3, 2021 | Trailblazers | 97 | Clippers | 110 |
| April | 6, 2021 | Trailblazers | 101 | Pelicans | 109 |
| April | 7, 2021 | Trailblazers | 99 | Spurs | 144 |
| April | 9, 2021 | Pacers | 134 | Trailblazers | 105 |
| April | 11, 2021 | Mavericks | 117 | Trailblazers | 114 |
| April | 14, 2021 | Pistons | 106 | Trailblazers | 100 |
| April | 16, 2021 | Nets | 128 | Trailblazers | 96 |
| April | 18, 2021 | Trailblazers | 89 | Bulls | 121 |
| April | 20, 2021 | Trailblazers | 115 | Hawks | 121 |
| April | 21, 2021 | Trailblazers | 93 | Pistons | 117 |
| April | 23, 2021 | Trailblazers | 101 | Wolves | 121 |
| April | 25, 2021 | Grizzlies | 132 | Trailblazers | 99 |
| April | 27, 2021 | Trailblazers | 112 | Nuggets | 114 |
| April | 29, 2021 | Nuggets | 100 | Trailblazers | 107 |
| April | 30, 2021 | Trailblazers | 120 | Lakers | 123 |
| May | 1, 2021 | Kings | 130 | Trailblazers | 103 |