| month | day | visitor | score | home | score |
|---|
| November | 4, 2020 | Pelicans | 82 | Rockets | 90 |
| November | 7, 2020 | Rockets | 98 | Lakers | 81 |
| November | 8, 2020 | Rockets | 93 | Clippers | 81 |
| November | 12, 2020 | Jazz | 91 | Rockets | 84 |
| November | 14, 2020 | Clippers | 75 | Rockets | 104 |
| November | 19, 2020 | Trailblazers | 96 | Rockets | 109 |
| November | 22, 2020 | Rockets | 101 | Nets | 90 |
| November | 23, 2020 | Rockets | 87 | Bulls | 96 |
| November | 25, 2020 | Rockets | 91 | Pacers | 98 |
| November | 28, 2020 | Rockets | 132 | Thunder | 108 |
| November | 30, 2020 | Rockets | 104 | Spurs | 112 |
| December | 1, 2020 | Pacers | 116 | Rockets | 123 |
| December | 3, 2020 | Rockets | 94 | Nuggets | 84 |
| December | 5, 2020 | Warriors | 87 | Rockets | 100 |
| December | 7, 2020 | Kings | 97 | Rockets | 79 |
| December | 11, 2020 | Pistons | 112 | Rockets | 102 |
| December | 13, 2020 | Rockets | 97 | Pistons | 106 |
| December | 15, 2020 | Rockets | 117 | Cavaliers | 121 |
| December | 17, 2020 | Rockets | 89 | Wizards | 94 |
| December | 19, 2020 | Mavericks | 99 | Rockets | 118 |
| December | 21, 2020 | Rockets | 101 | Spurs | 90 |
| December | 22, 2020 | Bulls | 71 | Rockets | 104 |
| December | 25, 2020 | Rockets | 86 | Wolves | 84 |
| December | 28, 2020 | Rockets | 83 | Jazz | 104 |
| December | 30, 2020 | Rockets | 107 | Mavericks | 79 |
| January | 2, 2021 | Trailblazers | 77 | Rockets | 124 |
| January | 4, 2021 | Lakers | 103 | Rockets | 113 |
| January | 6, 2021 | Rockets | 100 | Grizzlies | 96 |
| January | 8, 2021 | Jazz | 95 | Rockets | 92 |
| January | 10, 2021 | Wizards | 83 | Rockets | 80 |
| January | 11, 2021 | Rockets | 93 | Heat | 109 |
| January | 13, 2021 | Spurs | 108 | Rockets | 107 |
| January | 15, 2021 | Thunder | 77 | Rockets | 125 |
| January | 17, 2021 | Celtics | 99 | Rockets | 112 |
| January | 19, 2021 | Rockets | 88 | Pelicans | 103 |
| January | 21, 2021 | Grizzlies | 89 | Rockets | 106 |
| January | 24, 2021 | Rockets | 81 | Warriors | 85 |
| January | 26, 2021 | Rockets | 101 | Trailblazers | 105 |
| January | 28, 2021 | Nuggets | 75 | Rockets | 108 |
| January | 30, 2021 | Bucks | 105 | Rockets | 114 |
| February | 1, 2021 | Cavaliers | 99 | Rockets | 97 |
| February | 4, 2021 | Rockets | 100 | Magic | 121 |
| February | 5, 2021 | Grizzlies | 91 | Rockets | 122 |
| February | 7, 2021 | Nets | 114 | Rockets | 94 |
| February | 15, 2021 | Lakers | 92 | Rockets | 84 |
| February | 17, 2021 | Rockets | 116 | 76ers | 117 |
| February | 19, 2021 | Rockets | 89 | Knicks | 88 |
| February | 21, 2021 | Raptors | 107 | Rockets | 96 |
| February | 23, 2021 | Magic | 115 | Rockets | 135 |
| February | 25, 2021 | Pelicans | 109 | Rockets | 105 |
| February | 28, 2021 | Rockets | 106 | Nuggets | 104 |
| March | 2, 2021 | Rockets | 97 | Jazz | 86 |
| March | 4, 2021 | Rockets | 115 | Suns | 107 |
| March | 6, 2021 | Rockets | 85 | Kings | 108 |
| March | 9, 2021 | Thunder | 89 | Rockets | 125 |
| March | 11, 2021 | Mavericks | 104 | Rockets | 123 |
| March | 13, 2021 | Rockets | 88 | Wolves | 75 |
| March | 15, 2021 | Rockets | 110 | Lakers | 93 |
| March | 17, 2021 | Rockets | 86 | Warriors | 106 |
| March | 19, 2021 | Hawks | 108 | Rockets | 99 |
| March | 21, 2021 | Rockets | 108 | Hornets | 86 |
| March | 22, 2021 | Heat | 62 | Rockets | 101 |
| March | 25, 2021 | Rockets | 129 | Celtics | 114 |
| March | 27, 2021 | Rockets | 85 | Raptors | 107 |
| March | 30, 2021 | 76ers | 117 | Rockets | 106 |
| April | 1, 2021 | Rockets | 109 | Mavericks | 119 |
| April | 2, 2021 | Hornets | 97 | Rockets | 93 |
| April | 4, 2021 | Warriors | 95 | Rockets | 93 |
| April | 6, 2021 | Suns | 99 | Rockets | 117 |
| April | 8, 2021 | Wolves | 95 | Rockets | 97 |
| April | 10, 2021 | Rockets | 112 | Hawks | 120 |
| April | 11, 2021 | Rockets | 94 | Grizzlies | 122 |
| April | 13, 2021 | Spurs | 116 | Rockets | 96 |
| April | 15, 2021 | Rockets | 86 | Pelicans | 84 |
| April | 17, 2021 | Rockets | 106 | Bucks | 121 |
| April | 19, 2021 | Nuggets | 101 | Rockets | 105 |
| April | 21, 2021 | Kings | 100 | Rockets | 101 |
| April | 24, 2021 | Rockets | 59 | Kings | 94 |
| April | 25, 2021 | Rockets | 89 | Clippers | 96 |
| April | 27, 2021 | Knicks | 96 | Rockets | 90 |
| April | 29, 2021 | Suns | 86 | Rockets | 95 |
| April | 30, 2021 | Rockets | 102 | Thunder | 126 |