| month | day | visitor | score | home | score |
|---|
| November | 5, 2020 | Lakers | 119 | Trailblazers | 112 |
| November | 7, 2020 | Rockets | 98 | Lakers | 81 |
| November | 9, 2020 | Spurs | 129 | Lakers | 104 |
| November | 12, 2020 | Lakers | 101 | Suns | 120 |
| November | 13, 2020 | Nuggets | 112 | Lakers | 125 |
| November | 16, 2020 | Lakers | 102 | Spurs | 123 |
| November | 18, 2020 | Lakers | 110 | Wolves | 106 |
| November | 20, 2020 | Mavericks | 131 | Lakers | 118 |
| November | 23, 2020 | Lakers | 107 | Trailblazers | 104 |
| November | 24, 2020 | Raptors | 116 | Lakers | 108 |
| November | 27, 2020 | Wolves | 96 | Lakers | 100 |
| November | 30, 2020 | Lakers | 102 | Kings | 106 |
| December | 1, 2020 | Hawks | 119 | Lakers | 111 |
| December | 4, 2020 | Trailblazers | 110 | Lakers | 139 |
| December | 7, 2020 | Lakers | 110 | Magic | 111 |
| December | 8, 2020 | Lakers | 113 | Heat | 115 |
| December | 12, 2020 | Lakers | 105 | Cavaliers | 131 |
| December | 14, 2020 | Jazz | 95 | Lakers | 82 |
| December | 16, 2020 | Magic | 137 | Lakers | 114 |
| December | 18, 2020 | Lakers | 127 | Nuggets | 125 |
| December | 20, 2020 | Pacers | 99 | Lakers | 92 |
| December | 21, 2020 | Mavericks | 110 | Lakers | 114 |
| December | 23, 2020 | Suns | 101 | Lakers | 114 |
| December | 27, 2020 | Spurs | 135 | Lakers | 122 |
| December | 29, 2020 | Lakers | 98 | Spurs | 114 |
| December | 30, 2020 | Lakers | 107 | Grizzlies | 105 |
| January | 1, 2021 | Heat | 86 | Lakers | 111 |
| January | 4, 2021 | Lakers | 103 | Rockets | 113 |
| January | 6, 2021 | Lakers | 95 | Hornets | 98 |
| January | 7, 2021 | Lakers | 90 | Wizards | 112 |
| January | 9, 2021 | Lakers | 120 | Nets | 123 |
| January | 12, 2021 | Pelicans | 107 | Lakers | 95 |
| January | 14, 2021 | Grizzlies | 107 | Lakers | 123 |
| January | 15, 2021 | Lakers | 125 | Warriors | 130 |
| January | 17, 2021 | Lakers | 106 | Kings | 111 |
| January | 18, 2021 | Clippers | 126 | Lakers | 115 |
| January | 20, 2021 | Kings | 87 | Lakers | 79 |
| January | 23, 2021 | Thunder | 89 | Lakers | 115 |
| January | 25, 2021 | Knicks | 88 | Lakers | 90 |
| January | 27, 2021 | Lakers | 107 | Wolves | 102 |
| January | 28, 2021 | Lakers | 122 | Mavericks | 134 |
| January | 30, 2021 | Pistons | 106 | Lakers | 95 |
| February | 1, 2021 | Lakers | 69 | Jazz | 98 |
| February | 4, 2021 | Cavaliers | 75 | Lakers | 83 |
| February | 6, 2021 | Bulls | 100 | Lakers | 89 |
| February | 13, 2021 | Lakers | 108 | Thunder | 94 |
| February | 15, 2021 | Lakers | 92 | Rockets | 84 |
| February | 17, 2021 | Warriors | 122 | Lakers | 112 |
| February | 20, 2021 | Wolves | 111 | Lakers | 98 |
| February | 23, 2021 | Suns | 90 | Lakers | 94 |
| February | 25, 2021 | 76ers | 96 | Lakers | 120 |
| February | 27, 2021 | Lakers | 85 | Clippers | 106 |
| March | 2, 2021 | Lakers | 111 | Warriors | 112 |
| March | 5, 2021 | Lakers | 112 | Pacers | 116 |
| March | 7, 2021 | Lakers | 130 | Celtics | 114 |
| March | 10, 2021 | Lakers | 95 | 76ers | 113 |
| March | 12, 2021 | Lakers | 101 | Hawks | 107 |
| March | 15, 2021 | Rockets | 110 | Lakers | 93 |
| March | 17, 2021 | Lakers | 95 | Pelicans | 120 |
| March | 19, 2021 | Lakers | 103 | Grizzlies | 118 |
| March | 21, 2021 | Pelicans | 108 | Lakers | 115 |
| March | 23, 2021 | Bucks | 122 | Lakers | 106 |
| March | 24, 2021 | Lakers | 114 | Suns | 118 |
| March | 26, 2021 | Clippers | 96 | Lakers | 106 |
| March | 28, 2021 | Nuggets | 73 | Lakers | 131 |
| March | 31, 2021 | Celtics | 95 | Lakers | 114 |
| April | 3, 2021 | Lakers | 112 | Bulls | 128 |
| April | 5, 2021 | Lakers | 117 | Raptors | 130 |
| April | 6, 2021 | Lakers | 114 | Pistons | 115 |
| April | 8, 2021 | Lakers | 89 | Knicks | 105 |
| April | 10, 2021 | Lakers | 138 | Bucks | 143 |
| April | 13, 2021 | Nets | 94 | Lakers | 106 |
| April | 15, 2021 | Kings | 111 | Lakers | 120 |
| April | 17, 2021 | Wizards | 107 | Lakers | 125 |
| April | 18, 2021 | Lakers | 127 | Jazz | 120 |
| April | 20, 2021 | Hornets | 134 | Lakers | 104 |
| April | 22, 2021 | Lakers | 134 | Pelicans | 123 |
| April | 24, 2021 | Lakers | 143 | Thunder | 135 |
| April | 26, 2021 | Warriors | 119 | Lakers | 130 |
| April | 27, 2021 | Lakers | 104 | Clippers | 121 |
| April | 29, 2021 | Jazz | 127 | Lakers | 111 |
| April | 30, 2021 | Trailblazers | 120 | Lakers | 123 |