| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | 76ers | 113 | Celtics | 104 |
| November | 5, 2020 | Bulls | 103 | 76ers | 118 |
| November | 7, 2020 | Magic | 116 | 76ers | 119 |
| November | 10, 2020 | 76ers | 89 | Pistons | 121 |
| November | 12, 2020 | 76ers | 95 | Bucks | 120 |
| November | 16, 2020 | Hornets | 103 | 76ers | 115 |
| November | 18, 2020 | Hawks | 108 | 76ers | 115 |
| November | 19, 2020 | 76ers | 111 | Raptors | 120 |
| November | 21, 2020 | Clippers | 114 | 76ers | 115 |
| November | 23, 2020 | Pistons | 116 | 76ers | 103 |
| November | 24, 2020 | 76ers | 99 | Nets | 106 |
| November | 27, 2020 | 76ers | 119 | Pacers | 107 |
| November | 29, 2020 | Hornets | 132 | 76ers | 104 |
| November | 30, 2020 | 76ers | 124 | Grizzlies | 129 |
| December | 2, 2020 | 76ers | 108 | Heat | 119 |
| December | 4, 2020 | 76ers | 112 | Magic | 121 |
| December | 6, 2020 | Jazz | 103 | 76ers | 97 |
| December | 7, 2020 | 76ers | 104 | Hornets | 128 |
| December | 9, 2020 | Suns | 121 | 76ers | 106 |
| December | 12, 2020 | Pelicans | 112 | 76ers | 109 |
| December | 13, 2020 | Cavaliers | 121 | 76ers | 107 |
| December | 16, 2020 | 76ers | 108 | Nets | 107 |
| December | 19, 2020 | Knicks | 121 | 76ers | 98 |
| December | 21, 2020 | Wizards | 99 | 76ers | 104 |
| December | 23, 2020 | Grizzlies | 128 | 76ers | 104 |
| December | 27, 2020 | 76ers | 106 | Raptors | 121 |
| December | 29, 2020 | 76ers | 101 | Pistons | 109 |
| January | 1, 2021 | Pistons | 118 | 76ers | 135 |
| January | 3, 2021 | Nets | 110 | 76ers | 118 |
| January | 5, 2021 | Pacers | 104 | 76ers | 114 |
| January | 7, 2021 | 76ers | 111 | Cavaliers | 106 |
| January | 8, 2021 | 76ers | 118 | Spurs | 133 |
| January | 10, 2021 | Knicks | 122 | 76ers | 96 |
| January | 13, 2021 | Raptors | 120 | 76ers | 139 |
| January | 15, 2021 | 76ers | 123 | Celtics | 127 |
| January | 17, 2021 | 76ers | 124 | Jazz | 127 |
| January | 20, 2021 | 76ers | 121 | Trailblazers | 112 |
| January | 22, 2021 | 76ers | 117 | Clippers | 126 |
| January | 23, 2021 | 76ers | 91 | Suns | 96 |
| January | 26, 2021 | Mavericks | 134 | 76ers | 97 |
| January | 29, 2021 | Wizards | 127 | 76ers | 126 |
| January | 30, 2021 | 76ers | 119 | Wizards | 130 |
| February | 1, 2021 | Hawks | 122 | 76ers | 115 |
| February | 4, 2021 | 76ers | 106 | Knicks | 96 |
| February | 6, 2021 | Wolves | 99 | 76ers | 111 |
| February | 13, 2021 | 76ers | 100 | Pacers | 124 |
| February | 15, 2021 | Thunder | 101 | 76ers | 154 |
| February | 17, 2021 | Rockets | 116 | 76ers | 117 |
| February | 19, 2021 | Spurs | 121 | 76ers | 138 |
| February | 22, 2021 | 76ers | 103 | Nuggets | 114 |
| February | 25, 2021 | 76ers | 96 | Lakers | 120 |
| February | 27, 2021 | 76ers | 125 | Warriors | 129 |
| March | 2, 2021 | 76ers | 106 | Kings | 134 |
| March | 5, 2021 | Raptors | 93 | 76ers | 107 |
| March | 8, 2021 | Nuggets | 109 | 76ers | 127 |
| March | 10, 2021 | Lakers | 95 | 76ers | 113 |
| March | 12, 2021 | Celtics | 94 | 76ers | 115 |
| March | 13, 2021 | 76ers | 128 | Knicks | 121 |
| March | 15, 2021 | Heat | 92 | 76ers | 127 |
| March | 17, 2021 | Trailblazers | 104 | 76ers | 126 |
| March | 19, 2021 | 76ers | 117 | Pelicans | 115 |
| March | 22, 2021 | 76ers | 135 | Thunder | 126 |
| March | 24, 2021 | Warriors | 124 | 76ers | 108 |
| March | 27, 2021 | Magic | 120 | 76ers | 111 |
| March | 28, 2021 | 76ers | 118 | Bulls | 94 |
| March | 30, 2021 | 76ers | 117 | Rockets | 106 |
| April | 1, 2021 | Pacers | 103 | 76ers | 109 |
| April | 3, 2021 | Cavaliers | 113 | 76ers | 117 |
| April | 6, 2021 | Kings | 107 | 76ers | 97 |
| April | 8, 2021 | 76ers | 124 | Bucks | 122 |
| April | 10, 2021 | 76ers | 107 | Hornets | 132 |
| April | 11, 2021 | Celtics | 91 | 76ers | 125 |
| April | 14, 2021 | 76ers | 109 | Hawks | 106 |
| April | 16, 2021 | 76ers | 96 | Magic | 117 |
| April | 19, 2021 | Nets | 124 | 76ers | 125 |
| April | 21, 2021 | 76ers | 96 | Wolves | 121 |
| April | 23, 2021 | 76ers | 89 | Mavericks | 135 |
| April | 25, 2021 | 76ers | 94 | Hawks | 105 |
| April | 26, 2021 | Bucks | 109 | 76ers | 96 |
| April | 28, 2021 | 76ers | 103 | Bulls | 132 |
| April | 30, 2021 | 76ers | 116 | Heat | 88 |
| May | 1, 2021 | Bulls | 97 | 76ers | 92 |