| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Nets | 96 | Pistons | 125 |
| November | 5, 2020 | Pistons | 123 | Bucks | 111 |
| November | 7, 2020 | Hawks | 89 | Pistons | 115 |
| November | 8, 2020 | Mavericks | 80 | Pistons | 120 |
| November | 11, 2020 | Celtics | 89 | Pistons | 116 |
| November | 12, 2020 | 76ers | 112 | Pistons | 117 |
| November | 15, 2020 | Pelicans | 104 | Pistons | 124 |
| November | 16, 2020 | Magic | 120 | Pistons | 126 |
| November | 17, 2020 | Pistons | 99 | Jazz | 102 |
| November | 19, 2020 | Pistons | 107 | Raptors | 117 |
| November | 21, 2020 | Grizzlies | 128 | Pistons | 120 |
| November | 23, 2020 | Pistons | 111 | Hawks | 103 |
| November | 26, 2020 | Pistons | 111 | Knicks | 105 |
| November | 28, 2020 | Suns | 110 | Pistons | 101 |
| December | 1, 2020 | Pistons | 139 | Thunder | 138 |
| December | 2, 2020 | Wizards | 112 | Pistons | 127 |
| December | 5, 2020 | Pistons | 118 | Pacers | 125 |
| December | 6, 2020 | Warriors | 110 | Pistons | 129 |
| December | 7, 2020 | Pistons | 131 | Lakers | 101 |
| December | 10, 2020 | Raptors | 107 | Pistons | 109 |
| December | 12, 2020 | Pistons | 114 | Hornets | 88 |
| December | 15, 2020 | Bucks | 93 | Pistons | 127 |
| December | 16, 2020 | Pistons | 117 | Spurs | 111 |
| December | 19, 2020 | Pistons | 132 | Bulls | 109 |
| December | 22, 2020 | Nets | 99 | Pistons | 117 |
| December | 26, 2020 | Pacers | 107 | Pistons | 115 |
| December | 27, 2020 | Kings | 92 | Pistons | 108 |
| December | 29, 2020 | Rockets | 98 | Pistons | 122 |
| December | 30, 2020 | Bulls | 110 | Pistons | 137 |
| January | 2, 2021 | Bucks | 130 | Pistons | 134 |
| January | 3, 2021 | Pistons | 121 | Grizzlies | 132 |
| January | 5, 2021 | Pistons | 122 | Heat | 119 |
| January | 6, 2021 | Wolves | 95 | Pistons | 123 |
| January | 8, 2021 | Hawks | 117 | Pistons | 114 |
| January | 10, 2021 | Hornets | 111 | Pistons | 96 |
| January | 12, 2021 | Pistons | 109 | Cavaliers | 120 |
| January | 14, 2021 | Pistons | 127 | Wizards | 109 |
| January | 15, 2021 | Pistons | 94 | Kings | 119 |
| January | 18, 2021 | Trailblazers | 94 | Pistons | 123 |
| January | 20, 2021 | Clippers | 108 | Pistons | 103 |
| January | 23, 2021 | Pistons | 79 | Raptors | 120 |
| January | 26, 2021 | Pistons | 104 | Bucks | 135 |
| January | 29, 2021 | Pistons | 113 | Pelicans | 126 |
| January | 30, 2021 | Bulls | 98 | Pistons | 111 |
| February | 2, 2021 | Raptors | 112 | Pistons | 118 |
| February | 6, 2021 | Wizards | 108 | Pistons | 113 |
| February | 7, 2021 | Magic | 114 | Pistons | 129 |
| February | 13, 2021 | Pistons | 100 | Rockets | 106 |
| February | 15, 2021 | Pistons | 115 | Nuggets | 125 |
| February | 18, 2021 | Lakers | 83 | Pistons | 120 |
| February | 20, 2021 | Pistons | 126 | Knicks | 121 |
| February | 22, 2021 | Heat | 117 | Pistons | 124 |
| February | 24, 2021 | Jazz | 93 | Pistons | 100 |
| February | 27, 2021 | Pistons | 118 | Nets | 107 |
| March | 1, 2021 | Pistons | 93 | 76ers | 130 |
| March | 2, 2021 | Pistons | 98 | Mavericks | 114 |
| March | 5, 2021 | Thunder | 127 | Pistons | 105 |
| March | 7, 2021 | Pistons | 107 | Wolves | 116 |
| March | 8, 2021 | Pistons | 118 | Magic | 115 |
| March | 11, 2021 | Pistons | 102 | Warriors | 139 |
| March | 14, 2021 | Spurs | 119 | Pistons | 107 |
| March | 17, 2021 | Pistons | 123 | Celtics | 100 |
| March | 18, 2021 | Pistons | 134 | Bulls | 124 |
| March | 21, 2021 | Hornets | 88 | Pistons | 114 |
| March | 24, 2021 | Pistons | 116 | Cavaliers | 121 |
| March | 25, 2021 | Pistons | 114 | 76ers | 106 |
| March | 28, 2021 | Pistons | 126 | Nets | 99 |
| March | 31, 2021 | Pistons | 122 | Magic | 129 |
| April | 5, 2021 | Pistons | 123 | Clippers | 116 |
| April | 7, 2021 | Knicks | 83 | Pistons | 94 |
| April | 8, 2021 | Pistons | 104 | Wizards | 115 |
| April | 11, 2021 | Pistons | 138 | Heat | 107 |
| April | 13, 2021 | Pistons | 117 | Pacers | 110 |
| April | 15, 2021 | Knicks | 76 | Pistons | 127 |
| April | 17, 2021 | Cavaliers | 105 | Pistons | 121 |
| April | 18, 2021 | Celtics | 86 | Pistons | 128 |
| April | 20, 2021 | Pistons | 126 | Suns | 106 |
| April | 21, 2021 | Heat | 105 | Pistons | 132 |
| April | 24, 2021 | Nuggets | 93 | Pistons | 112 |
| April | 27, 2021 | Pistons | 107 | Hornets | 80 |
| April | 30, 2021 | 76ers | 112 | Pistons | 120 |
| May | 1, 2021 | Pistons | 119 | Trailblazers | 117 |
| Post | 1, 2021 | Hornets | 86 | Pistons | 92 |
| Post | 2, 2021 | Hornets | 96 | Pistons | 102 |
| Post | 3, 2021 | Pistons | 84 | Hornets | 77 |
| Post | 4, 2021 | Pistons | 82 | Hornets | 69 |
| Post | 5, 2021 | Hornets | | Pistons | |
| Post | 6, 2021 | Pistons | | Hornets | |
| Post | 7, 2021 | Hornets | | Pistons | |
| Post | 8, 2021 | Cavaliers | 91 | Pistons | 122 |
| Post | 9, 2021 | Cavaliers | 128 | Pistons | 125 |
| Post | 10, 2021 | Pistons | 118 | Cavaliers | 110 |
| Post | 11, 2021 | Pistons | 110 | Cavaliers | 92 |
| Post | 12, 2021 | Cavaliers | 97 | Pistons | 112 |
| Post | 13, 2021 | Pistons | | Cavaliers | |
| Post | 14, 2021 | Cavaliers | | Pistons | |
| Post | 15, 2021 | Pistons | 124 | Raptors | 109 |
| Post | 16, 2021 | Pistons | 109 | Raptors | 110 |
| Post | 17, 2021 | Raptors | 128 | Pistons | 94 |
| Post | 18, 2021 | Raptors | 118 | Pistons | 90 |
| Post | 19, 2021 | Pistons | 110 | Raptors | 104 |
| Post | 20, 2021 | Raptors | 110 | Pistons | 115 |
| Post | 21, 2021 | Pistons | 117 | Raptors | 122 |