| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Hornets | 98 | Knicks | 93 |
| November | 6, 2020 | Knicks | 100 | Nets | 99 |
| November | 8, 2020 | Knicks | 114 | Celtics | 123 |
| November | 12, 2020 | Lakers | 98 | Knicks | 122 |
| November | 13, 2020 | Knicks | 118 | Mavericks | 125 |
| November | 15, 2020 | Knicks | 103 | 76ers | 109 |
| November | 18, 2020 | Cavaliers | 108 | Knicks | 103 |
| November | 19, 2020 | Warriors | 113 | Knicks | 101 |
| November | 22, 2020 | Knicks | 94 | Clippers | 107 |
| November | 24, 2020 | Knicks | 84 | Heat | 115 |
| November | 26, 2020 | Pistons | 120 | Knicks | 92 |
| November | 29, 2020 | Knicks | 112 | Wizards | 115 |
| November | 30, 2020 | Bucks | 132 | Knicks | 104 |
| December | 2, 2020 | Knicks | 57 | Warriors | 113 |
| December | 4, 2020 | Pelicans | 123 | Knicks | 112 |
| December | 6, 2020 | Knicks | 95 | Raptors | 120 |
| December | 8, 2020 | Knicks | 92 | Lakers | 122 |
| December | 9, 2020 | Spurs | 126 | Knicks | 101 |
| December | 11, 2020 | Knicks | 88 | Pelicans | 108 |
| December | 13, 2020 | Knicks | 102 | Kings | 107 |
| December | 15, 2020 | Trailblazers | 131 | Knicks | 136 |
| December | 18, 2020 | Rockets | 89 | Knicks | 93 |
| December | 20, 2020 | Knicks | 84 | Magic | 140 |
| December | 22, 2020 | Hawks | 111 | Knicks | 110 |
| December | 25, 2020 | Nets | 102 | Knicks | 96 |
| December | 27, 2020 | Knicks | 88 | Hornets | 98 |
| December | 29, 2020 | Suns | 126 | Knicks | 121 |
| December | 31, 2020 | Knicks | 112 | Wolves | 117 |
| January | 3, 2021 | Heat | 104 | Knicks | 103 |
| January | 5, 2021 | Knicks | 94 | Pacers | 107 |
| January | 8, 2021 | Jazz | 131 | Knicks | 124 |
| January | 10, 2021 | Knicks | 105 | Hawks | 121 |
| January | 13, 2021 | Knicks | 88 | Suns | 106 |
| January | 15, 2021 | Clippers | 108 | Knicks | 111 |
| January | 17, 2021 | Raptors | 116 | Knicks | 87 |
| January | 21, 2021 | Knicks | 106 | Spurs | 136 |
| January | 23, 2021 | Wolves | 105 | Knicks | 125 |
| January | 24, 2021 | Kings | 96 | Knicks | 80 |
| January | 26, 2021 | Knicks | 112 | Nets | 113 |
| January | 28, 2021 | Grizzlies | 89 | Knicks | 85 |
| January | 31, 2021 | Knicks | 87 | Hawks | 91 |
| February | 2, 2021 | Bulls | 105 | Knicks | 101 |
| February | 4, 2021 | Knicks | 106 | Nuggets | 93 |
| February | 5, 2021 | Thunder | 133 | Knicks | 121 |
| February | 7, 2021 | Knicks | 95 | Pacers | 85 |
| February | 13, 2021 | Knicks | 89 | Raptors | 127 |
| February | 15, 2021 | Celtics | 90 | Knicks | 118 |
| February | 18, 2021 | Knicks | 101 | Bucks | 107 |
| February | 20, 2021 | Pistons | 100 | Knicks | 75 |
| February | 21, 2021 | Knicks | 93 | Bulls | 115 |
| February | 23, 2021 | Knicks | 76 | Rockets | 103 |
| February | 25, 2021 | Magic | 102 | Knicks | 133 |
| February | 27, 2021 | 76ers | 110 | Knicks | 98 |
| March | 1, 2021 | Knicks | 108 | Cavaliers | 144 |
| March | 4, 2021 | Hornets | 107 | Knicks | 90 |
| March | 7, 2021 | Knicks | 90 | Heat | 109 |
| March | 9, 2021 | Nuggets | 116 | Knicks | 86 |
| March | 10, 2021 | Knicks | 89 | Grizzlies | 123 |
| March | 12, 2021 | Knicks | 121 | Magic | 124 |
| March | 14, 2021 | Celtics | 124 | Knicks | 108 |
| March | 17, 2021 | Knicks | 86 | Hornets | 105 |
| March | 20, 2021 | Pacers | 100 | Knicks | 82 |
| March | 22, 2021 | Knicks | 86 | Bucks | 89 |
| March | 24, 2021 | Bulls | 79 | Knicks | 103 |
| March | 25, 2021 | Knicks | 81 | Wizards | 122 |
| March | 27, 2021 | Mavericks | 116 | Knicks | 91 |
| March | 29, 2021 | Cavaliers | 123 | Knicks | 102 |
| March | 31, 2021 | Knicks | 126 | Trailblazers | 123 |
| April | 1, 2021 | Knicks | 87 | Jazz | 102 |
| April | 4, 2021 | Bucks | 93 | Knicks | 105 |
| April | 7, 2021 | Knicks | 94 | Pistons | 113 |
| April | 10, 2021 | Knicks | 122 | Celtics | 142 |
| April | 13, 2021 | Hawks | 101 | Knicks | 105 |
| April | 15, 2021 | Knicks | 117 | Pistons | 145 |
| April | 18, 2021 | 76ers | 93 | Knicks | 99 |
| April | 20, 2021 | Wizards | 104 | Knicks | 136 |
| April | 22, 2021 | Nets | 100 | Knicks | 94 |
| April | 23, 2021 | Knicks | 99 | Bulls | 104 |
| April | 25, 2021 | Raptors | 115 | Knicks | 104 |
| April | 27, 2021 | Knicks | 121 | Thunder | 119 |
| April | 29, 2021 | Magic | 125 | Knicks | 123 |
| May | 1, 2021 | Heat | 122 | Knicks | 116 |