| month | day | visitor | score | home | score |
|---|
| November | 3, 2010 | Kings | 83 | Trailblazers | 84 |
| November | 5, 2010 | Trailblazers | 98 | Mavericks | 96 |
| November | 8, 2010 | Trailblazers | 104 | Cavaliers | 129 |
| November | 10, 2010 | Trailblazers | 120 | Lakers | 117 |
| November | 13, 2010 | Trailblazers | 96 | Wolves | 99 |
| November | 15, 2010 | Wizards | 101 | Trailblazers | 94 |
| November | 17, 2010 | Suns | 105 | Trailblazers | 102 |
| November | 19, 2010 | Trailblazers | 119 | Nuggets | 114 |
| November | 21, 2010 | Bucks | 97 | Trailblazers | 67 |
| November | 23, 2010 | Trailblazers | 102 | Suns | 100 |
| November | 25, 2010 | Hawks | 98 | Trailblazers | 82 |
| November | 27, 2010 | Trailblazers | 101 | Spurs | 102 |
| November | 28, 2010 | Thunder | 141 | Trailblazers | 98 |
| November | 30, 2010 | Trailblazers | 102 | Pacers | 85 |
| December | 2, 2010 | Grizzlies | 72 | Trailblazers | 102 |
| December | 5, 2010 | Trailblazers | 99 | Heat | 111 |
| December | 6, 2010 | Trailblazers | 93 | 76ers | 94 |
| December | 8, 2010 | Trailblazers | 102 | Raptors | 111 |
| December | 11, 2010 | Rockets | 79 | Trailblazers | 99 |
| December | 13, 2010 | Clippers | 112 | Trailblazers | 111 |
| December | 15, 2010 | Trailblazers | 101 | Knicks | 79 |
| December | 17, 2010 | Trailblazers | 68 | Celtics | 98 |
| December | 20, 2010 | Celtics | 85 | Trailblazers | 90 |
| December | 21, 2010 | Trailblazers | 97 | Warriors | 103 |
| December | 23, 2010 | Pelicans | 78 | Trailblazers | 94 |
| December | 26, 2010 | Wolves | 112 | Trailblazers | 101 |
| December | 27, 2010 | Trailblazers | 95 | Suns | 85 |
| December | 29, 2010 | Mavericks | 123 | Trailblazers | 127 |
| December | 30, 2010 | Trailblazers | 105 | Jazz | 110 |
| January | 2, 2011 | Trailblazers | 55 | Kings | 87 |
| January | 5, 2011 | Clippers | 108 | Trailblazers | 104 |
| January | 8, 2011 | Lakers | 131 | Trailblazers | 124 |
| January | 10, 2011 | Trailblazers | 88 | Nuggets | 108 |
| January | 11, 2011 | Jazz | 111 | Trailblazers | 110 |
| January | 13, 2011 | Trailblazers | 105 | Magic | 101 |
| January | 15, 2011 | Trailblazers | 107 | Warriors | 121 |
| January | 18, 2011 | Trailblazers | 103 | Pistons | 115 |
| January | 21, 2011 | Trailblazers | 80 | Bulls | 104 |
| January | 23, 2011 | Trailblazers | 96 | Hornets | 99 |
| January | 25, 2011 | Rockets | 111 | Trailblazers | 86 |
| January | 28, 2011 | Trailblazers | 87 | Hawks | 103 |
| February | 1, 2011 | Spurs | 112 | Trailblazers | 91 |
| February | 4, 2011 | Lakers | 117 | Trailblazers | 110 |
| February | 7, 2011 | Mavericks | 120 | Trailblazers | 115 |
| February | 13, 2011 | Trailblazers | 81 | Wizards | 127 |
| February | 15, 2011 | Magic | 99 | Trailblazers | 97 |
| February | 17, 2011 | Pacers | 83 | Trailblazers | 82 |
| February | 18, 2011 | 76ers | 95 | Trailblazers | 92 |
| February | 20, 2011 | Trailblazers | 101 | Pelicans | 123 |
| February | 22, 2011 | Nets | 84 | Trailblazers | 92 |
| February | 25, 2011 | Nuggets | 104 | Trailblazers | 108 |
| February | 27, 2011 | Trailblazers | 70 | Kings | 111 |
| March | 1, 2011 | Raptors | 97 | Trailblazers | 119 |
| March | 3, 2011 | Trailblazers | 106 | Rockets | 121 |
| March | 4, 2011 | Grizzlies | 91 | Trailblazers | 97 |
| March | 6, 2011 | Trailblazers | 105 | Lakers | 113 |
| March | 9, 2011 | Warriors | 105 | Trailblazers | 113 |
| March | 12, 2011 | Heat | 94 | Trailblazers | 90 |
| March | 13, 2011 | Hornets | 109 | Trailblazers | 98 |
| March | 15, 2011 | Trailblazers | 125 | Mavericks | 123 |
| March | 18, 2011 | Warriors | 112 | Trailblazers | 103 |
| March | 21, 2011 | Cavaliers | 128 | Trailblazers | 114 |
| March | 24, 2011 | Trailblazers | 105 | Pelicans | 113 |
| March | 27, 2011 | Bulls | 106 | Trailblazers | 110 |
| March | 29, 2011 | Trailblazers | 101 | Grizzlies | 111 |
| March | 31, 2011 | Knicks | 104 | Trailblazers | 121 |
| April | 2, 2011 | Nuggets | 103 | Trailblazers | 109 |
| April | 4, 2011 | Trailblazers | 72 | Nets | 100 |
| April | 6, 2011 | Trailblazers | 93 | Spurs | 117 |
| April | 9, 2011 | Trailblazers | 119 | Thunder | 135 |
| April | 12, 2011 | Jazz | 99 | Trailblazers | 112 |
| April | 14, 2011 | Trailblazers | 81 | Bucks | 114 |
| April | 16, 2011 | Spurs | 111 | Trailblazers | 97 |
| April | 17, 2011 | Trailblazers | 86 | Grizzlies | 127 |
| April | 19, 2011 | Thunder | 141 | Trailblazers | 117 |
| April | 21, 2011 | Trailblazers | 104 | Clippers | 107 |
| April | 22, 2011 | Wolves | 133 | Trailblazers | 107 |
| April | 24, 2011 | Trailblazers | 108 | Jazz | 123 |
| April | 25, 2011 | Trailblazers | 111 | Rockets | 104 |
| April | 27, 2011 | Trailblazers | 98 | Clippers | 108 |
| April | 29, 2011 | Suns | 76 | Trailblazers | 99 |
| May | 1, 2011 | Pistons | 109 | Trailblazers | 91 |