| month | day | visitor | score | home | score |
|---|
| November | 2, 2010 | Clippers | 96 | Lakers | 121 |
| November | 5, 2010 | Lakers | 118 | Jazz | 133 |
| November | 7, 2010 | Thunder | 114 | Lakers | 107 |
| November | 10, 2010 | Trailblazers | 107 | Lakers | 91 |
| November | 12, 2010 | Lakers | 97 | Knicks | 93 |
| November | 15, 2010 | Lakers | 114 | Nets | 129 |
| November | 17, 2010 | Nuggets | 114 | Lakers | 98 |
| November | 19, 2010 | Lakers | 97 | Spurs | 127 |
| November | 21, 2010 | Raptors | 135 | Lakers | 127 |
| November | 24, 2010 | Lakers | 93 | Warriors | 135 |
| November | 26, 2010 | Wolves | 108 | Lakers | 120 |
| November | 28, 2010 | Lakers | 115 | Celtics | 106 |
| November | 30, 2010 | Lakers | 115 | Wizards | 128 |
| December | 2, 2010 | Lakers | 111 | Kings | 117 |
| December | 4, 2010 | Mavericks | 106 | Lakers | 135 |
| December | 7, 2010 | Pistons | 99 | Lakers | 119 |
| December | 8, 2010 | Knicks | 115 | Lakers | 132 |
| December | 10, 2010 | Grizzlies | 112 | Lakers | 115 |
| December | 12, 2010 | Lakers | 109 | Suns | 124 |
| December | 15, 2010 | Pacers | 98 | Lakers | 99 |
| December | 17, 2010 | Magic | 101 | Lakers | 108 |
| December | 18, 2010 | Lakers | 114 | Jazz | 120 |
| December | 20, 2010 | Cavaliers | 121 | Lakers | 129 |
| December | 22, 2010 | Lakers | 134 | Thunder | 135 |
| December | 25, 2010 | Spurs | 111 | Lakers | 118 |
| December | 28, 2010 | Pelicans | 118 | Lakers | 117 |
| December | 30, 2010 | Lakers | 108 | Hornets | 139 |
| January | 1, 2011 | Lakers | 80 | Hawks | 136 |
| January | 4, 2011 | Lakers | 91 | Raptors | 99 |
| January | 6, 2011 | Rockets | 122 | Lakers | 111 |
| January | 8, 2011 | Lakers | 91 | Trailblazers | 119 |
| January | 10, 2011 | Heat | 108 | Lakers | 116 |
| January | 12, 2011 | Lakers | 97 | Mavericks | 117 |
| January | 16, 2011 | Lakers | 101 | Bulls | 130 |
| January | 19, 2011 | Lakers | 125 | 76ers | 129 |
| January | 20, 2011 | Lakers | 119 | Bucks | 104 |
| January | 21, 2011 | Hawks | 124 | Lakers | 135 |
| January | 24, 2011 | Spurs | 127 | Lakers | 99 |
| January | 27, 2011 | Lakers | 107 | Rockets | 104 |
| January | 28, 2011 | Kings | 114 | Lakers | 98 |
| January | 31, 2011 | Lakers | 105 | Grizzlies | 101 |
| February | 1, 2011 | Lakers | 115 | Nuggets | 107 |
| February | 4, 2011 | Lakers | 100 | Trailblazers | 116 |
| February | 5, 2011 | Lakers | 125 | Clippers | 112 |
| February | 7, 2011 | Hornets | 126 | Lakers | 132 |
| February | 14, 2011 | Suns | 113 | Lakers | 131 |
| February | 17, 2011 | Lakers | 82 | Cavaliers | 124 |
| February | 18, 2011 | Lakers | 81 | Pistons | 114 |
| February | 20, 2011 | Celtics | 119 | Lakers | 120 |
| February | 22, 2011 | Lakers | 105 | Pelicans | 137 |
| February | 24, 2011 | Warriors | 109 | Lakers | 111 |
| February | 26, 2011 | Lakers | 126 | Wolves | 100 |
| February | 28, 2011 | Wizards | 123 | Lakers | 118 |
| March | 2, 2011 | Lakers | 113 | Heat | 106 |
| March | 3, 2011 | Lakers | 115 | Magic | 107 |
| March | 6, 2011 | Trailblazers | 113 | Lakers | 118 |
| March | 7, 2011 | Lakers | 111 | Thunder | 117 |
| March | 9, 2011 | Pelicans | 94 | Lakers | 117 |
| March | 12, 2011 | Lakers | 108 | Pacers | 118 |
| March | 15, 2011 | Lakers | 105 | Spurs | 120 |
| March | 16, 2011 | Kings | 97 | Lakers | 118 |
| March | 19, 2011 | Lakers | 119 | Warriors | 96 |
| March | 22, 2011 | 76ers | 130 | Lakers | 110 |
| March | 24, 2011 | Suns | 95 | Lakers | 125 |
| March | 27, 2011 | Rockets | 125 | Lakers | 123 |
| March | 28, 2011 | Lakers | 101 | Nuggets | 102 |
| March | 30, 2011 | Jazz | 98 | Lakers | 131 |
| April | 1, 2011 | Lakers | 124 | Wolves | 119 |
| April | 2, 2011 | Lakers | 98 | Rockets | 108 |
| April | 4, 2011 | Thunder | 109 | Lakers | 149 |
| April | 7, 2011 | Lakers | 113 | Mavericks | 98 |
| April | 10, 2011 | Nets | 118 | Lakers | 131 |
| April | 13, 2011 | Lakers | 94 | Kings | 106 |
| April | 14, 2011 | Grizzlies | 94 | Lakers | 95 |
| April | 16, 2011 | Bucks | 123 | Lakers | 112 |
| April | 19, 2011 | Bulls | 96 | Lakers | 118 |
| April | 21, 2011 | Mavericks | 113 | Lakers | 114 |
| April | 24, 2011 | Lakers | 131 | Clippers | 98 |
| April | 25, 2011 | Lakers | 127 | Pelicans | 98 |
| April | 27, 2011 | Nuggets | 98 | Lakers | 93 |
| April | 28, 2011 | Warriors | 90 | Lakers | 136 |
| May | 1, 2011 | Wolves | 78 | Lakers | 123 |
| Post | 1, 2011 | Lakers | 93 | Spurs | 115 |
| Post | 2, 2011 | Lakers | 107 | Spurs | 136 |
| Post | 3, 2011 | Spurs | 116 | Lakers | 102 |
| Post | 4, 2011 | Spurs | 108 | Lakers | 123 |
| Post | 5, 2011 | Lakers | 110 | Spurs | 121 |
| Post | 6, 2011 | Spurs | | Lakers | |
| Post | 7, 2011 | Lakers | | Spurs | |