| month | day | visitor | score | home | score |
|---|
| November | 3, 2009 | Warriors | 96 | Grizzlies | 98 |
| November | 4, 2009 | Pacers | 101 | Grizzlies | 116 |
| November | 5, 2009 | Bucks | 98 | Grizzlies | 101 |
| November | 8, 2009 | Suns | 107 | Grizzlies | 90 |
| November | 10, 2009 | Grizzlies | 62 | Magic | 91 |
| November | 11, 2009 | Grizzlies | 58 | Clippers | 97 |
| November | 12, 2009 | Grizzlies | 87 | Spurs | 116 |
| November | 13, 2009 | Thunder | 98 | Grizzlies | 76 |
| November | 14, 2009 | Hornets | 74 | Grizzlies | 93 |
| November | 15, 2009 | Suns | 97 | Grizzlies | 64 |
| November | 16, 2009 | Grizzlies | 87 | Nets | 99 |
| November | 17, 2009 | Grizzlies | 95 | Clippers | 88 |
| November | 18, 2009 | Mavericks | 84 | Grizzlies | 92 |
| November | 24, 2009 | Grizzlies | 91 | Thunder | 103 |
| November | 25, 2009 | 76ers | 95 | Grizzlies | 102 |
| November | 29, 2009 | Nuggets | 95 | Grizzlies | 109 |
| December | 1, 2009 | Grizzlies | 87 | Wolves | 93 |
| December | 5, 2009 | Lakers | 97 | Grizzlies | 99 |
| December | 6, 2009 | Grizzlies | 91 | Suns | 101 |
| December | 7, 2009 | Grizzlies | 75 | Hawks | 82 |
| December | 10, 2009 | Blazers | 91 | Grizzlies | 97 |
| December | 15, 2009 | Grizzlies | 78 | Warriors | 89 |
| December | 18, 2009 | Rockets | 85 | Grizzlies | 76 |
| December | 19, 2009 | Bulls | 101 | Grizzlies | 85 |
| December | 21, 2009 | Warriors | 106 | Grizzlies | 81 |
| December | 24, 2009 | Wizards | 108 | Grizzlies | 94 |
| December | 25, 2009 | Grizzlies | 76 | Rockets | 91 |
| December | 30, 2009 | Grizzlies | 86 | Blazers | 105 |
| January | 1, 2010 | Grizzlies | 90 | Mavericks | 105 |
| January | 2, 2010 | Grizzlies | 89 | 76ers | 108 |
| January | 3, 2010 | Grizzlies | 71 | Raptors | 85 |
| January | 4, 2010 | Grizzlies | 104 | Blazers | 113 |
| January | 5, 2010 | Cavaliers | 102 | Grizzlies | 88 |
| January | 9, 2010 | Lakers | 104 | Grizzlies | 92 |
| January | 11, 2010 | Grizzlies | 82 | Lakers | 95 |
| January | 15, 2010 | Magic | 102 | Grizzlies | 93 |
| January | 16, 2010 | Grizzlies | 100 | Kings | 85 |
| January | 26, 2010 | Grizzlies | 92 | Pistons | 76 |
| January | 27, 2010 | Wolves | 76 | Grizzlies | 87 |
| February | 2, 2010 | Grizzlies | 97 | Mavericks | 92 |
| February | 6, 2010 | Grizzlies | 58 | Bobcats | 88 |
| February | 7, 2010 | Clippers | 104 | Grizzlies | 99 |
| February | 12, 2010 | Grizzlies | 87 | Suns | 88 |
| February | 14, 2010 | Blazers | 86 | Grizzlies | 79 |
| February | 15, 2010 | Grizzlies | 94 | Jazz | 86 |
| February | 17, 2010 | Hornets | 97 | Grizzlies | 106 |
| February | 18, 2010 | Nets | 78 | Grizzlies | 104 |
| February | 19, 2010 | Grizzlies | 80 | Heat | 88 |
| February | 21, 2010 | Jazz | 101 | Grizzlies | 77 |
| February | 22, 2010 | Bobcats | 81 | Grizzlies | 92 |
| March | 2, 2010 | Grizzlies | 89 | Wolves | 91 |
| March | 3, 2010 | Grizzlies | 89 | Bulls | 99 |
| March | 4, 2010 | Heat | 82 | Grizzlies | 83 |
| March | 5, 2010 | Spurs | 72 | Grizzlies | 109 |
| March | 6, 2010 | Nuggets | 93 | Grizzlies | 94 |
| March | 8, 2010 | Grizzlies | 84 | Jazz | 104 |
| March | 9, 2010 | Grizzlies | 95 | Pacers | 116 |
| March | 13, 2010 | Clippers | 79 | Grizzlies | 92 |
| March | 16, 2010 | Wolves | 99 | Grizzlies | 87 |
| March | 17, 2010 | Grizzlies | 85 | Thunder | 103 |
| March | 21, 2010 | Grizzlies | 80 | Cavaliers | 103 |
| March | 24, 2010 | Grizzlies | 93 | Bucks | 90 |
| March | 25, 2010 | Hawks | 75 | Grizzlies | 77 |
| March | 27, 2010 | Kings | 106 | Grizzlies | 94 |
| March | 28, 2010 | Celtics | 100 | Grizzlies | 83 |
| March | 30, 2010 | Rockets | 85 | Grizzlies | 75 |
| March | 31, 2010 | Raptors | 96 | Grizzlies | 82 |
| April | 2, 2010 | Grizzlies | 70 | Kings | 95 |
| April | 3, 2010 | Knicks | 85 | Grizzlies | 96 |
| April | 5, 2010 | Grizzlies | 106 | Hornets | 72 |
| April | 6, 2010 | Pistons | 94 | Grizzlies | 90 |
| April | 7, 2010 | Thunder | 96 | Grizzlies | 80 |
| April | 13, 2010 | Kings | 89 | Grizzlies | 88 |
| April | 14, 2010 | Grizzlies | 83 | Lakers | 90 |
| April | 16, 2010 | Grizzlies | 65 | Wizards | 70 |
| April | 17, 2010 | Grizzlies | 81 | Celtics | 107 |
| April | 19, 2010 | Spurs | 87 | Grizzlies | 103 |
| April | 23, 2010 | Grizzlies | 88 | Nuggets | 86 |
| April | 26, 2010 | Grizzlies | 100 | Nuggets | 78 |
| May | 1, 2010 | Grizzlies | 79 | Rockets | 102 |
| May | 2, 2010 | Grizzlies | 89 | Spurs | 102 |
| May | 3, 2010 | Grizzlies | 76 | Knicks | 86 |