| month | day | visitor | score | home | score |
|---|
| November | 2, 2009 | Kings | 87 | Cavaliers | 93 |
| November | 4, 2009 | Cavaliers | 94 | Jazz | 111 |
| November | 9, 2009 | Bulls | 105 | Cavaliers | 83 |
| November | 10, 2009 | Cavaliers | 83 | Warriors | 91 |
| November | 15, 2009 | Cavaliers | 97 | Raptors | 95 |
| November | 16, 2009 | Cavaliers | 94 | Knicks | 77 |
| November | 19, 2009 | Cavaliers | 114 | Spurs | 98 |
| November | 20, 2009 | Cavaliers | 108 | Nets | 101 |
| November | 30, 2009 | Cavaliers | 112 | Lakers | 109 |
| December | 1, 2009 | Spurs | 96 | Cavaliers | 127 |
| December | 3, 2009 | 76ers | 98 | Cavaliers | 90 |
| December | 5, 2009 | Cavaliers | 86 | Celtics | 98 |
| December | 6, 2009 | Blazers | 103 | Cavaliers | 117 |
| December | 7, 2009 | Raptors | 74 | Cavaliers | 88 |
| December | 9, 2009 | Cavaliers | 107 | Wolves | 111 |
| December | 13, 2009 | Cavaliers | 85 | Kings | 95 |
| December | 14, 2009 | Magic | 114 | Cavaliers | 93 |
| December | 15, 2009 | Nuggets | 86 | Cavaliers | 103 |
| December | 17, 2009 | Cavaliers | 100 | Hornets | 104 |
| December | 18, 2009 | Cavaliers | 89 | Bobcats | 91 |
| December | 19, 2009 | Jazz | 97 | Cavaliers | 125 |
| December | 20, 2009 | Nets | 100 | Cavaliers | 97 |
| December | 26, 2009 | Magic | 111 | Cavaliers | 121 |
| December | 28, 2009 | Cavaliers | 83 | Raptors | 84 |
| December | 29, 2009 | Wizards | 106 | Cavaliers | 99 |
| December | 30, 2009 | Knicks | 94 | Cavaliers | 87 |
| January | 5, 2010 | Cavaliers | 102 | Grizzlies | 88 |
| January | 6, 2010 | Cavaliers | 90 | Hawks | 107 |
| January | 7, 2010 | Cavaliers | 68 | Celtics | 119 |
| January | 8, 2010 | Nets | 86 | Cavaliers | 83 |
| January | 9, 2010 | Wizards | 110 | Cavaliers | 104 |
| January | 10, 2010 | Heat | 89 | Cavaliers | 101 |
| January | 11, 2010 | Knicks | 96 | Cavaliers | 104 |
| January | 14, 2010 | Cavaliers | 90 | Heat | 116 |
| January | 17, 2010 | Cavaliers | 123 | Pistons | 112 |
| January | 18, 2010 | Cavaliers | 112 | Thunder | 104 |
| January | 20, 2010 | Cavaliers | 109 | Nuggets | 116 |
| January | 21, 2010 | Bobcats | 106 | Cavaliers | 76 |
| January | 22, 2010 | Warriors | 86 | Cavaliers | 83 |
| January | 23, 2010 | Pacers | 115 | Cavaliers | 105 |
| January | 24, 2010 | Cavaliers | 111 | Bulls | 113 |
| January | 25, 2010 | Hawks | 96 | Cavaliers | 98 |
| January | 28, 2010 | Cavaliers | 110 | Knicks | 91 |
| January | 30, 2010 | Cavaliers | 122 | Blazers | 120 |
| February | 2, 2010 | Cavaliers | 109 | Pacers | 121 |
| February | 4, 2010 | Heat | 118 | Cavaliers | 127 |
| February | 7, 2010 | Cavaliers | 105 | Pistons | 98 |
| February | 11, 2010 | Bucks | 94 | Cavaliers | 85 |
| February | 12, 2010 | Celtics | 93 | Cavaliers | 66 |
| February | 13, 2010 | 76ers | 114 | Cavaliers | 94 |
| February | 14, 2010 | Cavaliers | 98 | 76ers | 95 |
| February | 15, 2010 | Cavaliers | 84 | Nets | 98 |
| February | 19, 2010 | Bucks | 79 | Cavaliers | 92 |
| February | 21, 2010 | Lakers | 97 | Cavaliers | 111 |
| February | 23, 2010 | Cavaliers | 80 | Hawks | 82 |
| February | 25, 2010 | Bobcats | 81 | Cavaliers | 104 |
| February | 26, 2010 | Raptors | 83 | Cavaliers | 93 |
| February | 28, 2010 | Hornets | 99 | Cavaliers | 117 |
| March | 1, 2010 | Celtics | 127 | Cavaliers | 120 |
| March | 7, 2010 | Rockets | 122 | Cavaliers | 111 |
| March | 9, 2010 | Cavaliers | 93 | Clippers | 91 |
| March | 11, 2010 | Suns | 97 | Cavaliers | 118 |
| March | 12, 2010 | Cavaliers | 108 | Rockets | 113 |
| March | 14, 2010 | Cavaliers | 130 | 76ers | 104 |
| March | 18, 2010 | Cavaliers | 108 | Magic | 107 |
| March | 21, 2010 | Grizzlies | 80 | Cavaliers | 103 |
| March | 22, 2010 | Clippers | 78 | Cavaliers | 101 |
| March | 23, 2010 | Cavaliers | 96 | Bobcats | 98 |
| March | 31, 2010 | Wolves | 109 | Cavaliers | 133 |
| April | 3, 2010 | Pistons | 113 | Cavaliers | 122 |
| April | 4, 2010 | Pistons | 100 | Cavaliers | 116 |
| April | 6, 2010 | Cavaliers | 110 | Pacers | 118 |
| April | 9, 2010 | Cavaliers | 95 | Suns | 106 |
| April | 11, 2010 | Cavaliers | 92 | Heat | 130 |
| April | 15, 2010 | Cavaliers | 93 | Wizards | 90 |
| April | 16, 2010 | Cavaliers | 82 | Bucks | 118 |
| April | 20, 2010 | Cavaliers | 92 | Wizards | 113 |
| April | 21, 2010 | Bulls | 112 | Cavaliers | 128 |
| April | 22, 2010 | Mavericks | 79 | Cavaliers | 103 |
| April | 24, 2010 | Thunder | 107 | Cavaliers | 126 |
| April | 26, 2010 | Cavaliers | 97 | Mavericks | 99 |
| May | 1, 2010 | Cavaliers | 118 | Magic | 116 |
| Post | 1, 2010 | Cavaliers | 110 | Celtics | 115 |
| Post | 2, 2010 | Cavaliers | 74 | Celtics | 104 |
| Post | 3, 2010 | Celtics | 115 | Cavaliers | 90 |
| Post | 4, 2010 | Celtics | 90 | Cavaliers | 105 |
| Post | 5, 2010 | Cavaliers | 112 | Celtics | 119 |
| Post | 6, 2010 | Celtics | | Cavaliers | |
| Post | 7, 2010 | Cavaliers | | Celtics | |