| month | day | visitor | score | home | score |
|---|
| November | 2, 2010 | Lakers | 82 | Heat | 118 |
| November | 4, 2010 | Lakers | 85 | Magic | 121 |
| November | 7, 2010 | Pelicans | 104 | Lakers | 113 |
| November | 9, 2010 | Lakers | 104 | Grizzlies | 112 |
| November | 10, 2010 | Wizards | 119 | Lakers | 137 |
| November | 12, 2010 | Hornets | 121 | Lakers | 98 |
| November | 16, 2010 | Lakers | 126 | Warriors | 99 |
| November | 17, 2010 | Lakers | 126 | Clippers | 112 |
| November | 19, 2010 | Lakers | 93 | Kings | 134 |
| November | 20, 2010 | Lakers | 87 | Nuggets | 88 |
| November | 23, 2010 | Lakers | 96 | Bulls | 116 |
| November | 25, 2010 | Lakers | 104 | Jazz | 135 |
| November | 27, 2010 | Jazz | 127 | Lakers | 105 |
| November | 28, 2010 | Nets | 95 | Lakers | 89 |
| November | 30, 2010 | Magic | 96 | Lakers | 105 |
| December | 4, 2010 | Lakers | 84 | Grizzlies | 93 |
| December | 7, 2010 | Rockets | 103 | Lakers | 102 |
| December | 9, 2010 | Mavericks | 104 | Lakers | 115 |
| December | 10, 2010 | Suns | 106 | Lakers | 95 |
| December | 13, 2010 | Raptors | 95 | Lakers | 106 |
| December | 15, 2010 | Heat | 87 | Lakers | 101 |
| December | 17, 2010 | Lakers | 97 | Wolves | 102 |
| December | 19, 2010 | Pelicans | 112 | Lakers | 108 |
| December | 21, 2010 | Spurs | 119 | Lakers | 117 |
| December | 26, 2010 | Trailblazers | 98 | Lakers | 101 |
| December | 29, 2010 | Warriors | 88 | Lakers | 104 |
| December | 31, 2010 | Grizzlies | 98 | Lakers | 91 |
| January | 2, 2011 | 76ers | 105 | Lakers | 77 |
| January | 3, 2011 | Knicks | 80 | Lakers | 105 |
| January | 5, 2011 | Nuggets | 98 | Lakers | 100 |
| January | 8, 2011 | Lakers | 101 | Cavaliers | 119 |
| January | 10, 2011 | Lakers | 109 | Bucks | 103 |
| January | 12, 2011 | Celtics | 81 | Lakers | 122 |
| January | 16, 2011 | Grizzlies | 90 | Lakers | 112 |
| January | 17, 2011 | Trailblazers | 99 | Lakers | 105 |
| January | 19, 2011 | Lakers | 90 | Pistons | 122 |
| January | 21, 2011 | Jazz | 93 | Lakers | 98 |
| January | 22, 2011 | Lakers | 87 | Rockets | 121 |
| January | 24, 2011 | Thunder | 87 | Lakers | 114 |
| January | 26, 2011 | Lakers | 88 | Jazz | 128 |
| January | 28, 2011 | Lakers | 98 | Trailblazers | 107 |
| January | 30, 2011 | Lakers | 99 | Rockets | 104 |
| February | 1, 2011 | Lakers | 66 | Spurs | 110 |
| February | 2, 2011 | Mavericks | 87 | Lakers | 113 |
| February | 4, 2011 | Lakers | 78 | Suns | 91 |
| February | 11, 2011 | Spurs | 117 | Lakers | 104 |
| February | 12, 2011 | Nuggets | 111 | Lakers | 90 |
| February | 14, 2011 | Lakers | 73 | Knicks | 103 |
| February | 15, 2011 | Cavaliers | 114 | Lakers | 96 |
| February | 16, 2011 | Lakers | 90 | Nets | 95 |
| February | 19, 2011 | Lakers | 104 | Thunder | 115 |
| February | 22, 2011 | Lakers | 98 | Trailblazers | 102 |
| February | 23, 2011 | Lakers | 108 | Warriors | 106 |
| February | 24, 2011 | Lakers | 94 | Hornets | 95 |
| February | 28, 2011 | Warriors | 80 | Lakers | 116 |
| March | 1, 2011 | Lakers | 105 | Thunder | 120 |
| March | 5, 2011 | Lakers | 104 | Hawks | 108 |
| March | 8, 2011 | Lakers | 99 | 76ers | 107 |
| March | 10, 2011 | Lakers | 104 | Pacers | 106 |
| March | 11, 2011 | Clippers | 99 | Lakers | 125 |
| March | 14, 2011 | Pacers | 112 | Lakers | 110 |
| March | 15, 2011 | Lakers | 125 | Celtics | 112 |
| March | 18, 2011 | Lakers | 117 | Pelicans | 109 |
| March | 19, 2011 | Wolves | 116 | Lakers | 111 |
| March | 21, 2011 | Clippers | 110 | Lakers | 105 |
| March | 22, 2011 | Hawks | 118 | Lakers | 125 |
| March | 24, 2011 | Bucks | 105 | Lakers | 108 |
| March | 28, 2011 | Lakers | 98 | Wizards | 122 |
| March | 31, 2011 | Lakers | 99 | Raptors | 102 |
| April | 2, 2011 | Lakers | 84 | Suns | 101 |
| April | 6, 2011 | Lakers | 116 | Nuggets | 134 |
| April | 7, 2011 | Lakers | 105 | Wolves | 128 |
| April | 9, 2011 | Lakers | 105 | Mavericks | 99 |
| April | 10, 2011 | Pistons | 126 | Lakers | 91 |
| April | 12, 2011 | Lakers | 105 | Pelicans | 103 |
| April | 15, 2011 | Wolves | 79 | Lakers | 109 |
| April | 16, 2011 | Kings | 100 | Lakers | 103 |
| April | 20, 2011 | Lakers | 114 | Mavericks | 119 |
| April | 21, 2011 | Lakers | 90 | Spurs | 125 |
| April | 25, 2011 | Rockets | 111 | Lakers | 84 |
| April | 28, 2011 | Kings | 105 | Lakers | 91 |
| May | 1, 2011 | Bulls | 105 | Lakers | 98 |