| month | day | visitor | score | home | score |
|---|
| November | 3, 2022 | Nets | 108 | Pistons | 90 |
| November | 5, 2022 | Pistons | 70 | Bucks | 99 |
| November | 7, 2022 | Hawks | 83 | Pistons | 80 |
| November | 8, 2022 | Mavericks | 100 | Pistons | 107 |
| November | 11, 2022 | Celtics | 94 | Pistons | 100 |
| November | 12, 2022 | 76ers | 90 | Pistons | 91 |
| November | 15, 2022 | Pelicans | 135 | Pistons | 133 |
| November | 16, 2022 | Magic | 99 | Pistons | 93 |
| November | 17, 2022 | Pistons | 93 | Jazz | 111 |
| November | 19, 2022 | Pistons | 88 | Raptors | 84 |
| November | 21, 2022 | Grizzlies | 89 | Pistons | 96 |
| November | 23, 2022 | Pistons | 96 | Hawks | 86 |
| November | 26, 2022 | Pistons | 73 | Knicks | 106 |
| November | 28, 2022 | Suns | 101 | Pistons | 109 |
| December | 1, 2022 | Pistons | 104 | Thunder | 112 |
| December | 2, 2022 | Wizards | 111 | Pistons | 95 |
| December | 5, 2022 | Pistons | 102 | Pacers | 128 |
| December | 6, 2022 | Warriors | 83 | Pistons | 93 |
| December | 7, 2022 | Pistons | 92 | Lakers | 84 |
| December | 10, 2022 | Raptors | 108 | Pistons | 89 |
| December | 12, 2022 | Pistons | 105 | Hornets | 106 |
| December | 15, 2022 | Bucks | 84 | Pistons | 79 |
| December | 16, 2022 | Pistons | 111 | Spurs | 118 |
| December | 19, 2022 | Pistons | 108 | Bulls | 111 |
| December | 22, 2022 | Nets | 90 | Pistons | 93 |
| December | 26, 2022 | Pacers | 118 | Pistons | 112 |
| December | 27, 2022 | Kings | 115 | Pistons | 96 |
| December | 29, 2022 | Rockets | 97 | Pistons | 87 |
| December | 30, 2022 | Bulls | 88 | Pistons | 91 |
| January | 2, 2023 | Bucks | 100 | Pistons | 75 |
| January | 3, 2023 | Pistons | 89 | Grizzlies | 88 |
| January | 5, 2023 | Pistons | 82 | Heat | 99 |
| January | 6, 2023 | Wolves | 97 | Pistons | 96 |
| January | 8, 2023 | Hawks | 107 | Pistons | 102 |
| January | 10, 2023 | Hornets | 82 | Pistons | 102 |
| January | 12, 2023 | Pistons | 105 | Cavaliers | 104 |
| January | 14, 2023 | Pistons | 88 | Wizards | 97 |
| January | 15, 2023 | Pistons | 87 | Kings | 105 |
| January | 18, 2023 | Trailblazers | 82 | Pistons | 89 |
| January | 20, 2023 | Clippers | 103 | Pistons | 89 |
| January | 23, 2023 | Pistons | 78 | Raptors | 105 |
| January | 26, 2023 | Pistons | 95 | Bucks | 96 |
| January | 29, 2023 | Pistons | 78 | Pelicans | 98 |
| January | 30, 2023 | Bulls | 103 | Pistons | 110 |
| February | 2, 2023 | Raptors | 78 | Pistons | 99 |
| February | 6, 2023 | Wizards | 102 | Pistons | 89 |
| February | 7, 2023 | Magic | 85 | Pistons | 89 |
| February | 11, 2023 | Pistons | 89 | Rockets | 100 |
| February | 15, 2023 | Pistons | 105 | Nuggets | 100 |
| February | 18, 2023 | Lakers | 92 | Pistons | 116 |
| February | 20, 2023 | Pistons | 111 | Knicks | 107 |
| February | 22, 2023 | Heat | 90 | Pistons | 111 |
| February | 24, 2023 | Jazz | 95 | Pistons | 108 |
| February | 27, 2023 | Pistons | 71 | Nets | 99 |
| March | 1, 2023 | Pistons | 119 | 76ers | 97 |
| March | 2, 2023 | Pistons | 113 | Mavericks | 96 |
| March | 5, 2023 | Thunder | 131 | Pistons | 121 |
| March | 7, 2023 | Pistons | 110 | Wolves | 109 |
| March | 8, 2023 | Pistons | 76 | Magic | 96 |
| March | 11, 2023 | Pistons | 83 | Warriors | 99 |
| March | 14, 2023 | Spurs | 126 | Pistons | 117 |
| March | 17, 2023 | Pistons | 110 | Celtics | 101 |
| March | 18, 2023 | Pistons | 100 | Bulls | 115 |
| March | 21, 2023 | Hornets | 82 | Pistons | 92 |
| March | 24, 2023 | Pistons | 97 | Cavaliers | 75 |
| March | 25, 2023 | Pistons | 114 | 76ers | 86 |
| March | 28, 2023 | Pistons | 62 | Nets | 104 |
| March | 31, 2023 | Pistons | 86 | Magic | 101 |
| April | 5, 2023 | Pistons | 90 | Clippers | 97 |
| April | 7, 2023 | Knicks | 82 | Pistons | 78 |
| April | 8, 2023 | Pistons | 89 | Wizards | 108 |
| April | 11, 2023 | Pistons | 91 | Heat | 97 |
| April | 13, 2023 | Pistons | 73 | Pacers | 123 |
| April | 15, 2023 | Knicks | 83 | Pistons | 90 |
| April | 17, 2023 | Cavaliers | 83 | Pistons | 113 |
| April | 18, 2023 | Celtics | 106 | Pistons | 119 |
| April | 20, 2023 | Pistons | 97 | Suns | 103 |
| April | 21, 2023 | Heat | 83 | Pistons | 81 |
| April | 24, 2023 | Nuggets | 89 | Pistons | 78 |
| April | 27, 2023 | Pistons | 74 | Hornets | 95 |
| April | 30, 2023 | 76ers | 95 | Pistons | 85 |
| May | 1, 2023 | Pistons | 84 | Trailblazers | 85 |