| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Magic | 90 | Trailblazers | 110 |
| November | 4, 2022 | Pacers | 119 | Trailblazers | 118 |
| November | 6, 2022 | Trailblazers | 96 | Nets | 93 |
| November | 7, 2022 | Suns | 107 | Trailblazers | 105 |
| November | 10, 2022 | Nuggets | 79 | Trailblazers | 80 |
| November | 12, 2022 | Thunder | 123 | Trailblazers | 109 |
| November | 13, 2022 | Wizards | 89 | Trailblazers | 107 |
| November | 15, 2022 | Trailblazers | 93 | Hawks | 95 |
| November | 18, 2022 | Bucks | 107 | Trailblazers | 70 |
| November | 21, 2022 | Trailblazers | 104 | Spurs | 116 |
| November | 22, 2022 | Jazz | 95 | Trailblazers | 112 |
| November | 26, 2022 | Warriors | 121 | Trailblazers | 94 |
| November | 29, 2022 | Trailblazers | 112 | Thunder | 122 |
| December | 1, 2022 | Grizzlies | 104 | Trailblazers | 108 |
| December | 5, 2022 | Clippers | 95 | Trailblazers | 85 |
| December | 7, 2022 | Cavaliers | 67 | Trailblazers | 90 |
| December | 8, 2022 | Knicks | 102 | Trailblazers | 94 |
| December | 11, 2022 | Trailblazers | 105 | Jazz | 98 |
| December | 14, 2022 | Trailblazers | 79 | Pacers | 113 |
| December | 15, 2022 | Kings | 135 | Trailblazers | 98 |
| December | 16, 2022 | Rockets | 95 | Trailblazers | 97 |
| December | 18, 2022 | Trailblazers | 84 | Cavaliers | 78 |
| December | 19, 2022 | Pistons | 78 | Trailblazers | 94 |
| December | 22, 2022 | Trailblazers | 106 | Jazz | 91 |
| December | 23, 2022 | Spurs | 92 | Trailblazers | 108 |
| December | 26, 2022 | Trailblazers | 90 | Lakers | 91 |
| December | 28, 2022 | Trailblazers | 101 | Mavericks | 110 |
| December | 29, 2022 | Mavericks | 109 | Trailblazers | 92 |
| December | 31, 2022 | Hornets | 89 | Trailblazers | 121 |
| January | 3, 2023 | Trailblazers | 106 | Heat | 97 |
| January | 5, 2023 | Trailblazers | 107 | Wizards | 99 |
| January | 8, 2023 | Trailblazers | 118 | Celtics | 116 |
| January | 9, 2023 | Trailblazers | 82 | Bulls | 114 |
| January | 12, 2023 | Raptors | 106 | Trailblazers | 107 |
| January | 13, 2023 | Trailblazers | 84 | Nuggets | 92 |
| January | 15, 2023 | Trailblazers | 99 | Grizzlies | 95 |
| January | 17, 2023 | Trailblazers | 117 | Lakers | 111 |
| January | 20, 2023 | 76ers | 115 | Trailblazers | 120 |
| January | 21, 2023 | Warriors | 102 | Trailblazers | 107 |
| January | 23, 2023 | Suns | 110 | Trailblazers | 103 |
| January | 24, 2023 | Trailblazers | 97 | Warriors | 101 |
| January | 28, 2023 | Lakers | 80 | Trailblazers | 129 |
| January | 29, 2023 | Mavericks | 106 | Trailblazers | 103 |
| February | 1, 2023 | Trailblazers | 103 | Warriors | 102 |
| February | 2, 2023 | Trailblazers | 91 | Clippers | 111 |
| February | 6, 2023 | Pelicans | 120 | Trailblazers | 119 |
| February | 13, 2023 | Trailblazers | 101 | Rockets | 110 |
| February | 14, 2023 | Trailblazers | 83 | Pistons | 85 |
| February | 18, 2023 | Rockets | 102 | Trailblazers | 106 |
| February | 21, 2023 | Trailblazers | 95 | Rockets | 90 |
| February | 22, 2023 | Lakers | 86 | Trailblazers | 118 |
| February | 24, 2023 | Trailblazers | 90 | Suns | 89 |
| February | 25, 2023 | Nuggets | 91 | Trailblazers | 103 |
| February | 27, 2023 | Trailblazers | 95 | Wolves | 102 |
| March | 1, 2023 | Heat | 107 | Trailblazers | 111 |
| March | 2, 2023 | Bulls | 106 | Trailblazers | 94 |
| March | 6, 2023 | Wolves | 103 | Trailblazers | 117 |
| March | 9, 2023 | Trailblazers | 121 | Pelicans | 108 |
| March | 10, 2023 | Thunder | 116 | Trailblazers | 121 |
| March | 12, 2023 | Trailblazers | 111 | Mavericks | 107 |
| March | 15, 2023 | Trailblazers | 90 | Grizzlies | 101 |
| March | 18, 2023 | Trailblazers | 112 | 76ers | 109 |
| March | 19, 2023 | Grizzlies | 91 | Trailblazers | 79 |
| March | 23, 2023 | Trailblazers | 112 | Thunder | 144 |
| March | 25, 2023 | Trailblazers | 78 | Bucks | 97 |
| March | 28, 2023 | Trailblazers | 91 | Nuggets | 85 |
| March | 30, 2023 | Pelicans | 108 | Trailblazers | 132 |
| March | 31, 2023 | Nets | 82 | Trailblazers | 102 |
| April | 2, 2023 | Trailblazers | 112 | Hornets | 98 |
| April | 5, 2023 | Trailblazers | 95 | Kings | 117 |
| April | 9, 2023 | Hawks | 99 | Trailblazers | 105 |
| April | 11, 2023 | Wolves | 97 | Trailblazers | 101 |
| April | 12, 2023 | Celtics | 127 | Trailblazers | 134 |
| April | 15, 2023 | Jazz | 85 | Trailblazers | 83 |
| April | 17, 2023 | Trailblazers | 98 | Knicks | 87 |
| April | 18, 2023 | Trailblazers | 111 | Pelicans | 123 |
| April | 21, 2023 | Trailblazers | 103 | Raptors | 107 |
| April | 22, 2023 | Trailblazers | 91 | Magic | 93 |
| April | 24, 2023 | Trailblazers | 84 | Kings | 100 |
| April | 27, 2023 | Trailblazers | 85 | Suns | 107 |
| April | 29, 2023 | Trailblazers | 87 | Clippers | 96 |
| April | 30, 2023 | Spurs | 132 | Trailblazers | 87 |