| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Pistons | 88 | Bucks | 114 |
| November | 3, 2022 | Pistons | 94 | Spurs | 117 |
| November | 5, 2022 | Warriors | 90 | Pistons | 100 |
| November | 6, 2022 | Wizards | 89 | Pistons | 82 |
| November | 8, 2022 | Wolves | 102 | Pistons | 100 |
| November | 9, 2022 | Pacers | 88 | Pistons | 81 |
| November | 11, 2022 | Pistons | 85 | Nets | 94 |
| November | 12, 2022 | 76ers | 104 | Pistons | 103 |
| November | 15, 2022 | Pistons | 96 | Raptors | 109 |
| November | 17, 2022 | Heat | 96 | Pistons | 79 |
| November | 21, 2022 | Pistons | 80 | Nuggets | 90 |
| November | 24, 2022 | Wizards | 80 | Pistons | 71 |
| November | 26, 2022 | Pistons | 89 | Rockets | 98 |
| November | 28, 2022 | Celtics | 90 | Pistons | 112 |
| November | 30, 2022 | Heat | 106 | Pistons | 100 |
| December | 3, 2022 | Pistons | 86 | Heat | 106 |
| December | 4, 2022 | Raptors | 90 | Pistons | 78 |
| December | 7, 2022 | Pistons | 79 | Bulls | 102 |
| December | 8, 2022 | Pistons | 80 | Kings | 106 |
| December | 12, 2022 | Bucks | 72 | Pistons | 85 |
| December | 15, 2022 | Spurs | 97 | Pistons | 91 |
| December | 17, 2022 | Nets | 87 | Pistons | 95 |
| December | 19, 2022 | Pistons | 78 | Trailblazers | 94 |
| December | 20, 2022 | Pistons | 84 | Bulls | 82 |
| December | 22, 2022 | Pistons | 104 | Hornets | 120 |
| December | 27, 2022 | Pistons | 71 | Bucks | 84 |
| December | 28, 2022 | Pistons | 95 | 76ers | 93 |
| December | 31, 2022 | Pistons | 105 | Celtics | 102 |
| January | 2, 2023 | Nets | 110 | Pistons | 92 |
| January | 3, 2023 | Pistons | 76 | Cavaliers | 87 |
| January | 5, 2023 | Pistons | 83 | Magic | 109 |
| January | 6, 2023 | Pistons | 105 | Thunder | 104 |
| January | 8, 2023 | Pistons | 89 | Wizards | 86 |
| January | 10, 2023 | Pistons | 85 | Knicks | 93 |
| January | 11, 2023 | Grizzlies | 94 | Pistons | 90 |
| January | 14, 2023 | Mavericks | 101 | Pistons | 94 |
| January | 16, 2023 | Clippers | 95 | Pistons | 79 |
| January | 17, 2023 | Magic | 81 | Pistons | 93 |
| January | 19, 2023 | Lakers | 75 | Pistons | 90 |
| January | 23, 2023 | Hawks | 96 | Pistons | 100 |
| January | 27, 2023 | Suns | 105 | Pistons | 114 |
| January | 29, 2023 | Bucks | 102 | Pistons | 99 |
| January | 31, 2023 | Pistons | 93 | 76ers | 94 |
| February | 2, 2023 | Pelicans | 108 | Pistons | 95 |
| February | 6, 2023 | Knicks | 99 | Pistons | 91 |
| February | 11, 2023 | Pistons | 83 | Hawks | 99 |
| February | 12, 2023 | Pistons | 89 | Raptors | 97 |
| February | 14, 2023 | Trailblazers | 83 | Pistons | 85 |
| February | 18, 2023 | Bulls | 92 | Pistons | 85 |
| February | 22, 2023 | Pistons | 98 | Knicks | 108 |
| February | 25, 2023 | Pistons | 91 | Wolves | 102 |
| February | 26, 2023 | Pistons | 98 | Magic | 94 |
| March | 3, 2023 | Hawks | 82 | Pistons | 99 |
| March | 4, 2023 | Pistons | 113 | Celtics | 100 |
| March | 9, 2023 | Pistons | 100 | Jazz | 113 |
| March | 11, 2023 | Kings | 83 | Pistons | 91 |
| March | 13, 2023 | Knicks | 87 | Pistons | 76 |
| March | 14, 2023 | 76ers | 114 | Pistons | 120 |
| March | 16, 2023 | Pistons | 86 | Hornets | 99 |
| March | 17, 2023 | Pistons | 81 | Nets | 84 |
| March | 20, 2023 | Cavaliers | 96 | Pistons | 105 |
| March | 21, 2023 | Pistons | 89 | Mavericks | 113 |
| March | 24, 2023 | Thunder | 112 | Pistons | 92 |
| March | 26, 2023 | Hornets | 90 | Pistons | 86 |
| March | 28, 2023 | Jazz | 83 | Pistons | 99 |
| March | 30, 2023 | Cavaliers | 95 | Pistons | 89 |
| April | 1, 2023 | Bulls | 115 | Pistons | 104 |
| April | 2, 2023 | Pacers | 103 | Pistons | 91 |
| April | 5, 2023 | Pistons | 88 | Wizards | 87 |
| April | 6, 2023 | Pistons | 110 | Suns | 114 |
| April | 10, 2023 | Pistons | 86 | Lakers | 87 |
| April | 14, 2023 | Pistons | 99 | Grizzlies | 109 |
| April | 16, 2023 | Pistons | 84 | Heat | 110 |
| April | 17, 2023 | Pistons | 107 | Pelicans | 111 |
| April | 20, 2023 | Magic | 104 | Pistons | 101 |
| April | 21, 2023 | Pistons | 90 | Clippers | 102 |
| April | 24, 2023 | Pistons | 97 | Pacers | 112 |
| April | 25, 2023 | Nuggets | 100 | Pistons | 97 |
| April | 27, 2023 | Rockets | 97 | Pistons | 75 |
| April | 28, 2023 | Pistons | 90 | Warriors | 97 |
| April | 30, 2023 | Pistons | 64 | Cavaliers | 102 |
| May | 1, 2023 | Celtics | 105 | Pistons | 111 |