| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Lakers | 82 | Heat | 122 |
| November | 4, 2022 | Lakers | 97 | Magic | 129 |
| November | 7, 2022 | Pelicans | 117 | Lakers | 112 |
| November | 9, 2022 | Lakers | 104 | Grizzlies | 117 |
| November | 10, 2022 | Wizards | 122 | Lakers | 110 |
| November | 12, 2022 | Hornets | 124 | Lakers | 109 |
| November | 16, 2022 | Lakers | 97 | Warriors | 101 |
| November | 17, 2022 | Lakers | 92 | Clippers | 102 |
| November | 19, 2022 | Lakers | 118 | Kings | 150 |
| November | 20, 2022 | Lakers | 89 | Nuggets | 100 |
| November | 23, 2022 | Lakers | 84 | Bulls | 89 |
| November | 25, 2022 | Lakers | 99 | Jazz | 94 |
| November | 27, 2022 | Jazz | 105 | Lakers | 92 |
| November | 28, 2022 | Nets | 89 | Lakers | 91 |
| November | 30, 2022 | Magic | 95 | Lakers | 85 |
| December | 4, 2022 | Lakers | 92 | Grizzlies | 106 |
| December | 7, 2022 | Rockets | 95 | Lakers | 75 |
| December | 9, 2022 | Mavericks | 119 | Lakers | 102 |
| December | 10, 2022 | Suns | 95 | Lakers | 82 |
| December | 13, 2022 | Raptors | 108 | Lakers | 101 |
| December | 15, 2022 | Heat | 103 | Lakers | 85 |
| December | 17, 2022 | Lakers | 75 | Wolves | 111 |
| December | 19, 2022 | Pelicans | 108 | Lakers | 109 |
| December | 21, 2022 | Spurs | 100 | Lakers | 108 |
| December | 26, 2022 | Trailblazers | 90 | Lakers | 91 |
| December | 29, 2022 | Warriors | 113 | Lakers | 93 |
| December | 31, 2022 | Grizzlies | 110 | Lakers | 92 |
| January | 2, 2023 | 76ers | 120 | Lakers | 119 |
| January | 3, 2023 | Knicks | 120 | Lakers | 124 |
| January | 5, 2023 | Nuggets | 107 | Lakers | 113 |
| January | 8, 2023 | Lakers | 99 | Cavaliers | 102 |
| January | 10, 2023 | Lakers | 52 | Bucks | 101 |
| January | 12, 2023 | Celtics | 111 | Lakers | 117 |
| January | 16, 2023 | Grizzlies | 76 | Lakers | 100 |
| January | 17, 2023 | Trailblazers | 117 | Lakers | 111 |
| January | 19, 2023 | Lakers | 75 | Pistons | 90 |
| January | 21, 2023 | Jazz | 120 | Lakers | 114 |
| January | 22, 2023 | Lakers | 96 | Rockets | 113 |
| January | 24, 2023 | Thunder | 110 | Lakers | 95 |
| January | 26, 2023 | Lakers | 105 | Jazz | 115 |
| January | 28, 2023 | Lakers | 80 | Trailblazers | 129 |
| January | 30, 2023 | Lakers | 94 | Rockets | 116 |
| February | 1, 2023 | Lakers | 92 | Spurs | 129 |
| February | 2, 2023 | Mavericks | 110 | Lakers | 99 |
| February | 4, 2023 | Lakers | 79 | Suns | 122 |
| February | 11, 2023 | Spurs | 125 | Lakers | 113 |
| February | 12, 2023 | Nuggets | 106 | Lakers | 89 |
| February | 14, 2023 | Lakers | 112 | Knicks | 114 |
| February | 15, 2023 | Cavaliers | 102 | Lakers | 104 |
| February | 16, 2023 | Lakers | 101 | Nets | 93 |
| February | 19, 2023 | Lakers | 98 | Thunder | 111 |
| February | 22, 2023 | Lakers | 86 | Trailblazers | 118 |
| February | 23, 2023 | Lakers | 117 | Warriors | 126 |
| February | 24, 2023 | Lakers | 98 | Hornets | 81 |
| February | 28, 2023 | Warriors | 120 | Lakers | 92 |
| March | 1, 2023 | Lakers | 92 | Thunder | 134 |
| March | 5, 2023 | Lakers | 102 | Hawks | 128 |
| March | 8, 2023 | Lakers | 92 | 76ers | 129 |
| March | 10, 2023 | Lakers | 114 | Pacers | 123 |
| March | 11, 2023 | Clippers | 82 | Lakers | 86 |
| March | 14, 2023 | Pacers | 119 | Lakers | 95 |
| March | 15, 2023 | Lakers | 84 | Celtics | 102 |
| March | 18, 2023 | Lakers | 84 | Pelicans | 121 |
| March | 19, 2023 | Wolves | 96 | Lakers | 100 |
| March | 21, 2023 | Clippers | 89 | Lakers | 87 |
| March | 22, 2023 | Hawks | 106 | Lakers | 113 |
| March | 24, 2023 | Bucks | 95 | Lakers | 75 |
| March | 28, 2023 | Lakers | 96 | Wizards | 113 |
| March | 31, 2023 | Lakers | 95 | Raptors | 101 |
| April | 2, 2023 | Lakers | 88 | Suns | 106 |
| April | 6, 2023 | Lakers | 84 | Nuggets | 120 |
| April | 7, 2023 | Lakers | 100 | Wolves | 109 |
| April | 9, 2023 | Lakers | 91 | Mavericks | 149 |
| April | 10, 2023 | Pistons | 86 | Lakers | 87 |
| April | 12, 2023 | Lakers | 92 | Pelicans | 129 |
| April | 15, 2023 | Wolves | 100 | Lakers | 110 |
| April | 16, 2023 | Kings | 105 | Lakers | 117 |
| April | 20, 2023 | Lakers | 103 | Mavericks | 123 |
| April | 21, 2023 | Lakers | 90 | Spurs | 135 |
| April | 25, 2023 | Rockets | 132 | Lakers | 68 |
| April | 28, 2023 | Kings | 109 | Lakers | 89 |
| May | 1, 2023 | Bulls | 98 | Lakers | 105 |