| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Magic | 91 | Trailblazers | 96 |
| November | 4, 2022 | Pacers | 89 | Trailblazers | 110 |
| November | 6, 2022 | Trailblazers | 86 | Nets | 92 |
| November | 7, 2022 | Suns | 81 | Trailblazers | 94 |
| November | 10, 2022 | Nuggets | 96 | Trailblazers | 91 |
| November | 12, 2022 | Thunder | 120 | Trailblazers | 112 |
| November | 13, 2022 | Wizards | 112 | Trailblazers | 95 |
| November | 15, 2022 | Trailblazers | 103 | Hawks | 89 |
| November | 18, 2022 | Bucks | 110 | Trailblazers | 101 |
| November | 21, 2022 | Trailblazers | 119 | Spurs | 129 |
| November | 22, 2022 | Jazz | 105 | Trailblazers | 111 |
| November | 26, 2022 | Warriors | 126 | Trailblazers | 109 |
| November | 29, 2022 | Trailblazers | 97 | Thunder | 138 |
| December | 1, 2022 | Grizzlies | 105 | Trailblazers | 108 |
| December | 5, 2022 | Clippers | 114 | Trailblazers | 124 |
| December | 7, 2022 | Cavaliers | 93 | Trailblazers | 102 |
| December | 8, 2022 | Knicks | 112 | Trailblazers | 106 |
| December | 11, 2022 | Trailblazers | 99 | Jazz | 101 |
| December | 14, 2022 | Trailblazers | 99 | Pacers | 113 |
| December | 15, 2022 | Kings | 115 | Trailblazers | 110 |
| December | 16, 2022 | Rockets | 114 | Trailblazers | 123 |
| December | 18, 2022 | Trailblazers | 96 | Cavaliers | 94 |
| December | 19, 2022 | Pistons | 108 | Trailblazers | 89 |
| December | 22, 2022 | Trailblazers | 108 | Jazz | 110 |
| December | 23, 2022 | Spurs | 132 | Trailblazers | 119 |
| December | 26, 2022 | Trailblazers | 105 | Lakers | 103 |
| December | 28, 2022 | Trailblazers | 109 | Mavericks | 121 |
| December | 29, 2022 | Mavericks | 118 | Trailblazers | 107 |
| December | 31, 2022 | Hornets | 96 | Trailblazers | 124 |
| January | 3, 2023 | Trailblazers | 107 | Heat | 108 |
| January | 5, 2023 | Trailblazers | 83 | Wizards | 81 |
| January | 8, 2023 | Trailblazers | 130 | Celtics | 102 |
| January | 9, 2023 | Trailblazers | 96 | Bulls | 108 |
| January | 12, 2023 | Raptors | 119 | Trailblazers | 121 |
| January | 13, 2023 | Trailblazers | 108 | Nuggets | 99 |
| January | 15, 2023 | Trailblazers | 85 | Grizzlies | 86 |
| January | 17, 2023 | Trailblazers | 115 | Lakers | 109 |
| January | 20, 2023 | 76ers | 107 | Trailblazers | 125 |
| January | 21, 2023 | Warriors | 128 | Trailblazers | 125 |
| January | 23, 2023 | Suns | 70 | Trailblazers | 98 |
| January | 24, 2023 | Trailblazers | 99 | Warriors | 113 |
| January | 28, 2023 | Lakers | 97 | Trailblazers | 109 |
| January | 29, 2023 | Mavericks | 114 | Trailblazers | 82 |
| February | 1, 2023 | Trailblazers | 95 | Warriors | 102 |
| February | 2, 2023 | Trailblazers | 72 | Clippers | 102 |
| February | 6, 2023 | Pelicans | 81 | Trailblazers | 100 |
| February | 13, 2023 | Trailblazers | 118 | Rockets | 104 |
| February | 14, 2023 | Trailblazers | 96 | Pistons | 94 |
| February | 18, 2023 | Rockets | 123 | Trailblazers | 105 |
| February | 21, 2023 | Trailblazers | 110 | Rockets | 128 |
| February | 22, 2023 | Lakers | 102 | Trailblazers | 115 |
| February | 24, 2023 | Trailblazers | 91 | Suns | 103 |
| February | 25, 2023 | Nuggets | 92 | Trailblazers | 119 |
| February | 27, 2023 | Trailblazers | 114 | Wolves | 106 |
| March | 1, 2023 | Heat | 108 | Trailblazers | 130 |
| March | 2, 2023 | Bulls | 97 | Trailblazers | 102 |
| March | 6, 2023 | Wolves | 112 | Trailblazers | 123 |
| March | 9, 2023 | Trailblazers | 98 | Pelicans | 120 |
| March | 10, 2023 | Thunder | 114 | Trailblazers | 120 |
| March | 12, 2023 | Trailblazers | 103 | Mavericks | 117 |
| March | 15, 2023 | Trailblazers | 109 | Grizzlies | 102 |
| March | 18, 2023 | Trailblazers | 87 | 76ers | 95 |
| March | 19, 2023 | Grizzlies | 112 | Trailblazers | 103 |
| March | 23, 2023 | Trailblazers | 104 | Thunder | 118 |
| March | 25, 2023 | Trailblazers | 92 | Bucks | 105 |
| March | 28, 2023 | Trailblazers | 94 | Nuggets | 120 |
| March | 30, 2023 | Pelicans | 104 | Trailblazers | 110 |
| March | 31, 2023 | Nets | 113 | Trailblazers | 111 |
| April | 2, 2023 | Trailblazers | 116 | Hornets | 92 |
| April | 5, 2023 | Trailblazers | 101 | Kings | 100 |
| April | 9, 2023 | Hawks | 95 | Trailblazers | 114 |
| April | 11, 2023 | Wolves | 115 | Trailblazers | 98 |
| April | 12, 2023 | Celtics | 110 | Trailblazers | 112 |
| April | 15, 2023 | Jazz | 108 | Trailblazers | 115 |
| April | 17, 2023 | Trailblazers | 98 | Knicks | 109 |
| April | 18, 2023 | Trailblazers | 120 | Pelicans | 112 |
| April | 21, 2023 | Trailblazers | 88 | Raptors | 111 |
| April | 22, 2023 | Trailblazers | 103 | Magic | 102 |
| April | 24, 2023 | Trailblazers | 122 | Kings | 115 |
| April | 27, 2023 | Trailblazers | 96 | Suns | 119 |
| April | 29, 2023 | Trailblazers | 99 | Clippers | 133 |
| April | 30, 2023 | Spurs | 109 | Trailblazers | 100 |