| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Lakers | 108 | Heat | 100 |
| November | 4, 2022 | Lakers | 101 | Magic | 115 |
| November | 7, 2022 | Pelicans | 121 | Lakers | 112 |
| November | 9, 2022 | Lakers | 99 | Grizzlies | 111 |
| November | 10, 2022 | Wizards | 108 | Lakers | 127 |
| November | 12, 2022 | Hornets | 82 | Lakers | 99 |
| November | 16, 2022 | Lakers | 90 | Warriors | 121 |
| November | 17, 2022 | Lakers | 128 | Clippers | 105 |
| November | 19, 2022 | Lakers | 124 | Kings | 122 |
| November | 20, 2022 | Lakers | 107 | Nuggets | 113 |
| November | 23, 2022 | Lakers | 107 | Bulls | 100 |
| November | 25, 2022 | Lakers | 113 | Jazz | 105 |
| November | 27, 2022 | Jazz | 130 | Lakers | 116 |
| November | 28, 2022 | Nets | 118 | Lakers | 105 |
| November | 30, 2022 | Magic | 126 | Lakers | 112 |
| December | 4, 2022 | Lakers | 92 | Grizzlies | 108 |
| December | 7, 2022 | Rockets | 111 | Lakers | 96 |
| December | 9, 2022 | Mavericks | 106 | Lakers | 98 |
| December | 10, 2022 | Suns | 93 | Lakers | 91 |
| December | 13, 2022 | Raptors | 128 | Lakers | 112 |
| December | 15, 2022 | Heat | 99 | Lakers | 120 |
| December | 17, 2022 | Lakers | 106 | Wolves | 116 |
| December | 19, 2022 | Pelicans | 79 | Lakers | 83 |
| December | 21, 2022 | Spurs | 134 | Lakers | 118 |
| December | 26, 2022 | Trailblazers | 105 | Lakers | 103 |
| December | 29, 2022 | Warriors | 121 | Lakers | 105 |
| December | 31, 2022 | Grizzlies | 88 | Lakers | 118 |
| January | 2, 2023 | 76ers | 115 | Lakers | 121 |
| January | 3, 2023 | Knicks | 118 | Lakers | 110 |
| January | 5, 2023 | Nuggets | 123 | Lakers | 92 |
| January | 8, 2023 | Lakers | 92 | Cavaliers | 99 |
| January | 10, 2023 | Lakers | 71 | Bucks | 103 |
| January | 12, 2023 | Celtics | 114 | Lakers | 109 |
| January | 16, 2023 | Grizzlies | 104 | Lakers | 113 |
| January | 17, 2023 | Trailblazers | 115 | Lakers | 109 |
| January | 19, 2023 | Lakers | 89 | Pistons | 124 |
| January | 21, 2023 | Jazz | 128 | Lakers | 119 |
| January | 22, 2023 | Lakers | 119 | Rockets | 132 |
| January | 24, 2023 | Thunder | 123 | Lakers | 106 |
| January | 26, 2023 | Lakers | 101 | Jazz | 122 |
| January | 28, 2023 | Lakers | 97 | Trailblazers | 109 |
| January | 30, 2023 | Lakers | 113 | Rockets | 130 |
| February | 1, 2023 | Lakers | 93 | Spurs | 107 |
| February | 2, 2023 | Mavericks | 117 | Lakers | 100 |
| February | 4, 2023 | Lakers | 100 | Suns | 104 |
| February | 11, 2023 | Spurs | 109 | Lakers | 119 |
| February | 12, 2023 | Nuggets | 122 | Lakers | 97 |
| February | 14, 2023 | Lakers | 114 | Knicks | 116 |
| February | 15, 2023 | Cavaliers | 97 | Lakers | 105 |
| February | 16, 2023 | Lakers | 101 | Nets | 98 |
| February | 19, 2023 | Lakers | 91 | Thunder | 122 |
| February | 22, 2023 | Lakers | 102 | Trailblazers | 115 |
| February | 23, 2023 | Lakers | 94 | Warriors | 130 |
| February | 24, 2023 | Lakers | 98 | Hornets | 94 |
| February | 28, 2023 | Warriors | 106 | Lakers | 101 |
| March | 1, 2023 | Lakers | 131 | Thunder | 106 |
| March | 5, 2023 | Lakers | 118 | Hawks | 108 |
| March | 8, 2023 | Lakers | 119 | 76ers | 114 |
| March | 10, 2023 | Lakers | 106 | Pacers | 97 |
| March | 11, 2023 | Clippers | 117 | Lakers | 125 |
| March | 14, 2023 | Pacers | 104 | Lakers | 107 |
| March | 15, 2023 | Lakers | 116 | Celtics | 84 |
| March | 18, 2023 | Lakers | 116 | Pelicans | 107 |
| March | 19, 2023 | Wolves | 126 | Lakers | 101 |
| March | 21, 2023 | Clippers | 103 | Lakers | 123 |
| March | 22, 2023 | Hawks | 97 | Lakers | 109 |
| March | 24, 2023 | Bucks | 101 | Lakers | 86 |
| March | 28, 2023 | Lakers | 95 | Wizards | 123 |
| March | 31, 2023 | Lakers | 90 | Raptors | 100 |
| April | 2, 2023 | Lakers | 101 | Suns | 106 |
| April | 6, 2023 | Lakers | 85 | Nuggets | 100 |
| April | 7, 2023 | Lakers | 89 | Wolves | 114 |
| April | 9, 2023 | Lakers | 95 | Mavericks | 116 |
| April | 10, 2023 | Pistons | 104 | Lakers | 101 |
| April | 12, 2023 | Lakers | 113 | Pelicans | 117 |
| April | 15, 2023 | Wolves | 113 | Lakers | 89 |
| April | 16, 2023 | Kings | 120 | Lakers | 139 |
| April | 20, 2023 | Lakers | 99 | Mavericks | 122 |
| April | 21, 2023 | Lakers | 81 | Spurs | 121 |
| April | 25, 2023 | Rockets | 113 | Lakers | 93 |
| April | 28, 2023 | Kings | 86 | Lakers | 95 |
| May | 1, 2023 | Bulls | 106 | Lakers | 85 |