| month | day | visitor | score | home | score |
|---|
| November | 5, 2021 | Heat | 85 | Wizards | 98 |
| November | 7, 2021 | Raptors | 122 | Wizards | 86 |
| November | 9, 2021 | Wizards | 96 | Trailblazers | 76 |
| November | 12, 2021 | Wizards | 113 | Warriors | 115 |
| November | 14, 2021 | Wizards | 129 | Kings | 121 |
| November | 17, 2021 | Wizards | 105 | Clippers | 115 |
| November | 19, 2021 | Wizards | 84 | Grizzlies | 93 |
| November | 22, 2021 | Thunder | 102 | Wizards | 120 |
| November | 24, 2021 | Knicks | 78 | Wizards | 99 |
| November | 26, 2021 | Wizards | 109 | Mavericks | 95 |
| November | 29, 2021 | Wizards | 125 | Magic | 119 |
| November | 30, 2021 | Wizards | 82 | Heat | 86 |
| December | 2, 2021 | Magic | 111 | Wizards | 118 |
| December | 4, 2021 | Cavaliers | 88 | Wizards | 117 |
| December | 6, 2021 | Nets | 110 | Wizards | 94 |
| December | 8, 2021 | Trailblazers | 81 | Wizards | 99 |
| December | 10, 2021 | Clippers | 106 | Wizards | 108 |
| December | 13, 2021 | Wizards | 104 | Raptors | 118 |
| December | 15, 2021 | Pelicans | 76 | Wizards | 99 |
| December | 17, 2021 | Rockets | 106 | Wizards | 95 |
| December | 19, 2021 | Wizards | 104 | Pelicans | 94 |
| December | 21, 2021 | Wizards | 86 | 76ers | 106 |
| December | 22, 2021 | Nets | 80 | Wizards | 104 |
| December | 25, 2021 | Wizards | 101 | Knicks | 79 |
| December | 27, 2021 | Wizards | 86 | Hawks | 79 |
| December | 30, 2021 | Wizards | 117 | Cavaliers | 125 |
| January | 1, 2022 | Wizards | 99 | Pacers | 106 |
| January | 3, 2022 | Celtics | 83 | Wizards | 108 |
| January | 5, 2022 | Wizards | 97 | Nets | 89 |
| January | 7, 2022 | Lakers | 96 | Wizards | 145 |
| January | 9, 2022 | Wizards | 92 | Hawks | 88 |
| January | 10, 2022 | Wizards | 92 | Rockets | 88 |
| January | 13, 2022 | Suns | 67 | Wizards | 114 |
| January | 14, 2022 | Wizards | 103 | Pacers | 107 |
| January | 16, 2022 | Wizards | 92 | Pistons | 97 |
| January | 18, 2022 | Bulls | 95 | Wizards | 107 |
| January | 19, 2022 | Hornets | 64 | Wizards | 94 |
| January | 23, 2022 | Hawks | 91 | Wizards | 103 |
| January | 25, 2022 | Wizards | 91 | Heat | 83 |
| January | 27, 2022 | Wizards | 119 | Thunder | 117 |
| January | 29, 2022 | Wizards | 88 | 76ers | 100 |
| January | 30, 2022 | 76ers | 85 | Wizards | 104 |
| February | 1, 2022 | Bucks | 104 | Wizards | 121 |
| February | 4, 2022 | Raptors | 109 | Wizards | 127 |
| February | 13, 2022 | Knicks | 72 | Wizards | 106 |
| February | 17, 2022 | Pistons | 96 | Wizards | 104 |
| February | 20, 2022 | Warriors | 129 | Wizards | 113 |
| February | 21, 2022 | Wizards | 125 | Magic | 115 |
| February | 23, 2022 | Wizards | 103 | Spurs | 125 |
| February | 25, 2022 | Wizards | 132 | Cavaliers | 107 |
| February | 26, 2022 | Pacers | 121 | Wizards | 115 |
| March | 1, 2022 | Bucks | 90 | Wizards | 104 |
| March | 4, 2022 | Hawks | 83 | Wizards | 93 |
| March | 6, 2022 | Wizards | 104 | Bucks | 121 |
| March | 8, 2022 | Cavaliers | 109 | Wizards | 117 |
| March | 9, 2022 | Wizards | 102 | Bulls | 98 |
| March | 11, 2022 | Wizards | 107 | Pistons | 103 |
| March | 13, 2022 | Wizards | 96 | Raptors | 109 |
| March | 16, 2022 | Wizards | 99 | Hornets | 90 |
| March | 17, 2022 | Pacers | 118 | Wizards | 108 |
| March | 21, 2022 | Wizards | 92 | Nets | 84 |
| March | 23, 2022 | Wizards | 108 | Celtics | 102 |
| March | 25, 2022 | Wolves | 94 | Wizards | 76 |
| March | 28, 2022 | Mavericks | 82 | Wizards | 116 |
| March | 30, 2022 | Wizards | 94 | Hornets | 100 |
| March | 31, 2022 | Wizards | 96 | Wolves | 91 |
| April | 2, 2022 | Kings | 118 | Wizards | 135 |
| April | 4, 2022 | Magic | 111 | Wizards | 125 |
| April | 6, 2022 | Hornets | 96 | Wizards | 91 |
| April | 7, 2022 | Grizzlies | 127 | Wizards | 93 |
| April | 9, 2022 | Jazz | 122 | Wizards | 120 |
| April | 11, 2022 | Wizards | 96 | Bulls | 83 |
| April | 12, 2022 | Nuggets | 104 | Wizards | 105 |
| April | 14, 2022 | Heat | 89 | Wizards | 109 |
| April | 17, 2022 | Wizards | 129 | Lakers | 126 |
| April | 18, 2022 | Wizards | 116 | Suns | 105 |
| April | 20, 2022 | Wizards | 94 | Jazz | 108 |
| April | 22, 2022 | Wizards | 101 | Nuggets | 81 |
| April | 25, 2022 | Bulls | 77 | Wizards | 107 |
| April | 27, 2022 | Spurs | 125 | Wizards | 110 |
| April | 29, 2022 | Wizards | 104 | Knicks | 92 |
| April | 30, 2022 | Celtics | 84 | Wizards | 106 |
| Post | 1, 2022 | Bulls | 83 | Wizards | 84 |
| Post | 2, 2022 | Bulls | 108 | Wizards | 88 |
| Post | 3, 2022 | Wizards | 83 | Bulls | 85 |
| Post | 4, 2022 | Wizards | 101 | Bulls | 104 |
| Post | 5, 2022 | Bulls | 91 | Wizards | 89 |
| Post | 6, 2022 | Wizards | | Bulls | |
| Post | 7, 2022 | Bulls | | Wizards | |