| month | day | visitor | score | home | score |
|---|
| November | 5, 2021 | Lakers | 116 | Trailblazers | 111 |
| November | 7, 2021 | Spurs | 123 | Trailblazers | 116 |
| November | 9, 2021 | Wizards | 96 | Trailblazers | 76 |
| November | 13, 2021 | Trailblazers | 99 | Magic | 117 |
| November | 16, 2021 | Trailblazers | 99 | Heat | 110 |
| November | 18, 2021 | Trailblazers | 112 | Pacers | 118 |
| November | 19, 2021 | Trailblazers | 89 | Rockets | 113 |
| November | 21, 2021 | Pelicans | 106 | Trailblazers | 99 |
| November | 23, 2021 | Lakers | 119 | Trailblazers | 109 |
| November | 24, 2021 | Wolves | 88 | Trailblazers | 93 |
| November | 26, 2021 | Bucks | 110 | Trailblazers | 118 |
| November | 28, 2021 | Clippers | 100 | Trailblazers | 116 |
| December | 1, 2021 | Celtics | 97 | Trailblazers | 105 |
| December | 4, 2021 | Trailblazers | 109 | Lakers | 111 |
| December | 6, 2021 | Trailblazers | 91 | Wolves | 90 |
| December | 8, 2021 | Trailblazers | 81 | Wizards | 99 |
| December | 10, 2021 | Trailblazers | 87 | Knicks | 89 |
| December | 11, 2021 | Trailblazers | 95 | Bucks | 118 |
| December | 14, 2021 | Trailblazers | 106 | Warriors | 118 |
| December | 16, 2021 | Clippers | 103 | Trailblazers | 122 |
| December | 19, 2021 | Magic | 88 | Trailblazers | 107 |
| December | 21, 2021 | Nuggets | 102 | Trailblazers | 113 |
| December | 23, 2021 | Trailblazers | 94 | Spurs | 118 |
| December | 26, 2021 | Trailblazers | 95 | Mavericks | 118 |
| December | 28, 2021 | Suns | 84 | Trailblazers | 110 |
| December | 30, 2021 | Wolves | 106 | Trailblazers | 88 |
| January | 2, 2022 | Trailblazers | 61 | Rockets | 102 |
| January | 3, 2022 | Trailblazers | 69 | Grizzlies | 120 |
| January | 5, 2022 | Raptors | 95 | Trailblazers | 99 |
| January | 8, 2022 | Trailblazers | 114 | Clippers | 100 |
| January | 11, 2022 | Grizzlies | 100 | Trailblazers | 98 |
| January | 12, 2022 | Jazz | 125 | Trailblazers | 88 |
| January | 14, 2022 | Mavericks | 103 | Trailblazers | 101 |
| January | 15, 2022 | Trailblazers | 143 | Jazz | 152 |
| January | 17, 2022 | Trailblazers | 116 | Warriors | 129 |
| January | 19, 2022 | Warriors | 138 | Trailblazers | 136 |
| January | 20, 2022 | 76ers | 103 | Trailblazers | 104 |
| January | 22, 2022 | Trailblazers | 131 | Kings | 121 |
| January | 25, 2022 | Thunder | 132 | Trailblazers | 98 |
| January | 26, 2022 | Rockets | 108 | Trailblazers | 98 |
| January | 28, 2022 | Knicks | 88 | Trailblazers | 103 |
| January | 30, 2022 | Bulls | 99 | Trailblazers | 106 |
| February | 1, 2022 | Hornets | 105 | Trailblazers | 117 |
| February | 4, 2022 | Trailblazers | 105 | Nuggets | 96 |
| February | 5, 2022 | Trailblazers | 120 | Kings | 132 |
| February | 7, 2022 | Cavaliers | 110 | Trailblazers | 100 |
| February | 14, 2022 | Pelicans | 101 | Trailblazers | 90 |
| February | 17, 2022 | Trailblazers | 98 | Jazz | 115 |
| February | 18, 2022 | Trailblazers | 128 | Thunder | 115 |
| February | 20, 2022 | Trailblazers | 104 | Suns | 82 |
| February | 22, 2022 | Hawks | 102 | Trailblazers | 94 |
| February | 26, 2022 | Jazz | 111 | Trailblazers | 115 |
| March | 5, 2022 | Heat | 86 | Trailblazers | 91 |
| March | 7, 2022 | Spurs | 130 | Trailblazers | 122 |
| March | 10, 2022 | Trailblazers | 73 | Mavericks | 107 |
| March | 11, 2022 | Trailblazers | 118 | Thunder | 102 |
| March | 13, 2022 | Warriors | 124 | Trailblazers | 97 |
| March | 15, 2022 | Trailblazers | 88 | Nets | 104 |
| March | 17, 2022 | Trailblazers | 74 | 76ers | 111 |
| March | 19, 2022 | Trailblazers | 90 | Cavaliers | 107 |
| March | 21, 2022 | Trailblazers | 95 | Celtics | 114 |
| March | 23, 2022 | Trailblazers | 88 | Raptors | 96 |
| March | 25, 2022 | Trailblazers | 84 | Hornets | 93 |
| March | 27, 2022 | Trailblazers | 101 | Grizzlies | 119 |
| March | 29, 2022 | Thunder | 100 | Trailblazers | 119 |
| March | 31, 2022 | Suns | 77 | Trailblazers | 94 |
| April | 3, 2022 | Trailblazers | 82 | Clippers | 119 |
| April | 6, 2022 | Trailblazers | 79 | Pelicans | 104 |
| April | 7, 2022 | Trailblazers | 109 | Spurs | 108 |
| April | 9, 2022 | Pacers | 113 | Trailblazers | 129 |
| April | 11, 2022 | Mavericks | 97 | Trailblazers | 106 |
| April | 14, 2022 | Pistons | 97 | Trailblazers | 94 |
| April | 16, 2022 | Nets | 90 | Trailblazers | 89 |
| April | 18, 2022 | Trailblazers | 89 | Bulls | 93 |
| April | 20, 2022 | Trailblazers | 101 | Hawks | 107 |
| April | 21, 2022 | Trailblazers | 86 | Pistons | 106 |
| April | 23, 2022 | Trailblazers | 77 | Wolves | 96 |
| April | 25, 2022 | Grizzlies | 94 | Trailblazers | 104 |
| April | 27, 2022 | Trailblazers | 85 | Nuggets | 92 |
| April | 29, 2022 | Nuggets | 73 | Trailblazers | 101 |
| April | 30, 2022 | Trailblazers | 129 | Lakers | 120 |
| May | 1, 2022 | Kings | 126 | Trailblazers | 132 |