| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Pelicans | 87 | Rockets | 101 |
| November | 7, 2021 | Rockets | 110 | Lakers | 123 |
| November | 8, 2021 | Rockets | 103 | Clippers | 101 |
| November | 12, 2021 | Jazz | 99 | Rockets | 111 |
| November | 14, 2021 | Clippers | 90 | Rockets | 93 |
| November | 19, 2021 | Trailblazers | 89 | Rockets | 113 |
| November | 22, 2021 | Rockets | 97 | Nets | 84 |
| November | 23, 2021 | Rockets | 78 | Bulls | 98 |
| November | 25, 2021 | Rockets | 76 | Pacers | 94 |
| November | 28, 2021 | Rockets | 96 | Thunder | 105 |
| November | 30, 2021 | Rockets | 84 | Spurs | 117 |
| December | 1, 2021 | Pacers | 68 | Rockets | 91 |
| December | 3, 2021 | Rockets | 87 | Nuggets | 102 |
| December | 5, 2021 | Warriors | 118 | Rockets | 97 |
| December | 7, 2021 | Kings | 124 | Rockets | 122 |
| December | 11, 2021 | Pistons | 100 | Rockets | 92 |
| December | 13, 2021 | Rockets | 85 | Pistons | 101 |
| December | 15, 2021 | Rockets | 115 | Cavaliers | 117 |
| December | 17, 2021 | Rockets | 106 | Wizards | 95 |
| December | 19, 2021 | Mavericks | 93 | Rockets | 97 |
| December | 21, 2021 | Rockets | 88 | Spurs | 115 |
| December | 22, 2021 | Bulls | 92 | Rockets | 102 |
| December | 25, 2021 | Rockets | 83 | Wolves | 110 |
| December | 28, 2021 | Rockets | 106 | Jazz | 98 |
| December | 30, 2021 | Rockets | 80 | Mavericks | 100 |
| January | 2, 2022 | Trailblazers | 61 | Rockets | 102 |
| January | 4, 2022 | Lakers | 124 | Rockets | 127 |
| January | 6, 2022 | Rockets | 90 | Grizzlies | 96 |
| January | 8, 2022 | Jazz | 92 | Rockets | 101 |
| January | 10, 2022 | Wizards | 92 | Rockets | 88 |
| January | 11, 2022 | Rockets | 100 | Heat | 102 |
| January | 13, 2022 | Spurs | 109 | Rockets | 87 |
| January | 15, 2022 | Thunder | 125 | Rockets | 131 |
| January | 17, 2022 | Celtics | 86 | Rockets | 116 |
| January | 19, 2022 | Rockets | 84 | Pelicans | 106 |
| January | 21, 2022 | Grizzlies | 112 | Rockets | 102 |
| January | 24, 2022 | Rockets | 120 | Warriors | 103 |
| January | 26, 2022 | Rockets | 108 | Trailblazers | 98 |
| January | 28, 2022 | Nuggets | 95 | Rockets | 84 |
| January | 30, 2022 | Bucks | 103 | Rockets | 121 |
| February | 1, 2022 | Cavaliers | 72 | Rockets | 109 |
| February | 4, 2022 | Rockets | 111 | Magic | 122 |
| February | 5, 2022 | Grizzlies | 93 | Rockets | 122 |
| February | 7, 2022 | Nets | 95 | Rockets | 85 |
| February | 15, 2022 | Lakers | 103 | Rockets | 137 |
| February | 17, 2022 | Rockets | 99 | 76ers | 100 |
| February | 19, 2022 | Rockets | 82 | Knicks | 89 |
| February | 21, 2022 | Raptors | 76 | Rockets | 98 |
| February | 23, 2022 | Magic | 126 | Rockets | 123 |
| February | 25, 2022 | Pelicans | 93 | Rockets | 97 |
| February | 28, 2022 | Rockets | 103 | Nuggets | 86 |
| March | 2, 2022 | Rockets | 104 | Jazz | 106 |
| March | 4, 2022 | Rockets | 83 | Suns | 85 |
| March | 6, 2022 | Rockets | 111 | Kings | 124 |
| March | 9, 2022 | Thunder | 105 | Rockets | 102 |
| March | 11, 2022 | Mavericks | 88 | Rockets | 96 |
| March | 13, 2022 | Rockets | 68 | Wolves | 82 |
| March | 15, 2022 | Rockets | 124 | Lakers | 127 |
| March | 17, 2022 | Rockets | 86 | Warriors | 133 |
| March | 19, 2022 | Hawks | 87 | Rockets | 69 |
| March | 21, 2022 | Rockets | 73 | Hornets | 110 |
| March | 22, 2022 | Heat | 101 | Rockets | 103 |
| March | 25, 2022 | Rockets | 96 | Celtics | 100 |
| March | 27, 2022 | Rockets | 78 | Raptors | 106 |
| March | 30, 2022 | 76ers | 95 | Rockets | 105 |
| April | 1, 2022 | Rockets | 70 | Mavericks | 95 |
| April | 2, 2022 | Hornets | 102 | Rockets | 104 |
| April | 4, 2022 | Warriors | 100 | Rockets | 98 |
| April | 6, 2022 | Suns | 101 | Rockets | 99 |
| April | 8, 2022 | Wolves | 104 | Rockets | 75 |
| April | 10, 2022 | Rockets | 86 | Hawks | 92 |
| April | 11, 2022 | Rockets | 73 | Grizzlies | 96 |
| April | 13, 2022 | Spurs | 103 | Rockets | 93 |
| April | 15, 2022 | Rockets | 90 | Pelicans | 114 |
| April | 17, 2022 | Rockets | 108 | Bucks | 141 |
| April | 19, 2022 | Nuggets | 87 | Rockets | 92 |
| April | 21, 2022 | Kings | 99 | Rockets | 127 |
| April | 24, 2022 | Rockets | 111 | Kings | 116 |
| April | 25, 2022 | Rockets | 99 | Clippers | 109 |
| April | 27, 2022 | Knicks | 102 | Rockets | 95 |
| April | 29, 2022 | Suns | 113 | Rockets | 99 |
| April | 30, 2022 | Rockets | 106 | Thunder | 93 |