| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Cavaliers | 94 | Raptors | 112 |
| November | 6, 2021 | Celtics | 105 | Raptors | 129 |
| November | 7, 2021 | Raptors | 122 | Wizards | 86 |
| November | 9, 2021 | Hornets | 93 | Raptors | 125 |
| November | 11, 2021 | Wolves | 91 | Raptors | 99 |
| November | 14, 2021 | Mavericks | 106 | Raptors | 120 |
| November | 18, 2021 | Raptors | 111 | Bucks | 115 |
| November | 19, 2021 | 76ers | 114 | Raptors | 112 |
| November | 22, 2021 | Raptors | 105 | Suns | 89 |
| November | 24, 2021 | Raptors | 123 | Lakers | 121 |
| November | 25, 2021 | Raptors | 109 | Jazz | 110 |
| November | 27, 2021 | Raptors | 113 | Kings | 129 |
| November | 30, 2021 | Knicks | 81 | Raptors | 104 |
| December | 2, 2021 | Pelicans | 79 | Raptors | 118 |
| December | 4, 2021 | Pistons | 110 | Raptors | 108 |
| December | 6, 2021 | Raptors | 125 | Celtics | 99 |
| December | 7, 2021 | Raptors | 113 | Bulls | 105 |
| December | 10, 2021 | Raptors | 108 | Magic | 92 |
| December | 12, 2021 | Raptors | 106 | Hawks | 103 |
| December | 13, 2021 | Wizards | 104 | Raptors | 118 |
| December | 16, 2021 | Heat | 92 | Raptors | 104 |
| December | 18, 2021 | Raptors | 122 | Grizzlies | 111 |
| December | 20, 2021 | Warriors | 105 | Raptors | 127 |
| December | 22, 2021 | Raptors | 120 | Cavaliers | 99 |
| December | 25, 2021 | Nuggets | 96 | Raptors | 112 |
| December | 27, 2021 | 76ers | 100 | Raptors | 101 |
| December | 29, 2021 | Raptors | 96 | Nets | 80 |
| December | 31, 2021 | Bucks | 102 | Raptors | 118 |
| January | 2, 2022 | Raptors | 118 | Clippers | 80 |
| January | 3, 2022 | Raptors | 129 | Warriors | 115 |
| January | 5, 2022 | Raptors | 95 | Trailblazers | 99 |
| January | 7, 2022 | Raptors | 111 | Nuggets | 116 |
| January | 10, 2022 | Pacers | 128 | Raptors | 126 |
| January | 12, 2022 | Cavaliers | 110 | Raptors | 127 |
| January | 13, 2022 | Raptors | 111 | 76ers | 106 |
| January | 16, 2022 | Raptors | 121 | Heat | 97 |
| January | 18, 2022 | Raptors | 113 | Magic | 124 |
| January | 20, 2022 | Bulls | 109 | Raptors | 106 |
| January | 22, 2022 | Jazz | 99 | Raptors | 112 |
| January | 24, 2022 | Raptors | 100 | Spurs | 115 |
| January | 26, 2022 | Raptors | 127 | Bucks | 139 |
| January | 27, 2022 | Pacers | 112 | Raptors | 105 |
| January | 29, 2022 | Hawks | 88 | Raptors | 91 |
| February | 1, 2022 | Nets | 82 | Raptors | 101 |
| February | 4, 2022 | Raptors | 109 | Wizards | 127 |
| February | 7, 2022 | Raptors | 122 | Celtics | 114 |
| February | 13, 2022 | Suns | 87 | Raptors | 127 |
| February | 15, 2022 | Grizzlies | 115 | Raptors | 125 |
| February | 18, 2022 | Kings | 101 | Raptors | 138 |
| February | 19, 2022 | Raptors | 112 | Pacers | 119 |
| February | 21, 2022 | Raptors | 76 | Rockets | 98 |
| February | 23, 2022 | Raptors | 116 | Mavericks | 92 |
| February | 27, 2022 | Bucks | 110 | Raptors | 118 |
| March | 3, 2022 | Clippers | 128 | Raptors | 116 |
| March | 5, 2022 | Raptors | 110 | 76ers | 102 |
| March | 7, 2022 | Raptors | 108 | Hawks | 88 |
| March | 9, 2022 | Raptors | 108 | Knicks | 84 |
| March | 11, 2022 | Nets | 75 | Raptors | 104 |
| March | 13, 2022 | Wizards | 96 | Raptors | 109 |
| March | 16, 2022 | Spurs | 112 | Raptors | 139 |
| March | 18, 2022 | Magic | 98 | Raptors | 128 |
| March | 20, 2022 | Celtics | 108 | Raptors | 123 |
| March | 23, 2022 | Trailblazers | 88 | Raptors | 96 |
| March | 25, 2022 | Raptors | 99 | Pistons | 104 |
| March | 27, 2022 | Rockets | 78 | Raptors | 106 |
| March | 30, 2022 | Raptors | 131 | Pelicans | 108 |
| April | 1, 2022 | Raptors | 126 | Heat | 120 |
| April | 2, 2022 | Raptors | 131 | Cavaliers | 114 |
| April | 5, 2022 | Lakers | 126 | Raptors | 117 |
| April | 8, 2022 | Raptors | 102 | Pistons | 120 |
| April | 9, 2022 | Knicks | 57 | Raptors | 76 |
| April | 11, 2022 | Raptors | 114 | Thunder | 102 |
| April | 13, 2022 | Thunder | 102 | Raptors | 134 |
| April | 15, 2022 | Hornets | 98 | Raptors | 116 |
| April | 17, 2022 | Bulls | 121 | Raptors | 106 |
| April | 19, 2022 | Raptors | 89 | Knicks | 84 |
| April | 21, 2022 | Raptors | 107 | Bulls | 100 |
| April | 23, 2022 | Magic | 99 | Raptors | 122 |
| April | 25, 2022 | Raptors | 114 | Nets | 98 |
| April | 27, 2022 | Raptors | 87 | Hornets | 105 |
| April | 29, 2022 | Heat | 108 | Raptors | 122 |
| April | 30, 2022 | Raptors | 103 | Wolves | 119 |
| Post | 1, 2022 | Hawks | 67 | Raptors | 80 |
| Post | 2, 2022 | Hawks | 112 | Raptors | 107 |
| Post | 3, 2022 | Raptors | 89 | Hawks | 94 |
| Post | 4, 2022 | Raptors | 92 | Hawks | 97 |
| Post | 5, 2022 | Hawks | 79 | Raptors | 106 |
| Post | 6, 2022 | Raptors | 93 | Hawks | 89 |
| Post | 7, 2022 | Hawks | 93 | Raptors | 95 |
| Post | 8, 2022 | Bulls | 105 | Raptors | 93 |
| Post | 9, 2022 | Bulls | 99 | Raptors | 86 |
| Post | 10, 2022 | Raptors | 95 | Bulls | 120 |
| Post | 11, 2022 | Raptors | 96 | Bulls | 98 |
| Post | 12, 2022 | Bulls | | Raptors | |
| Post | 13, 2022 | Raptors | | Bulls | |
| Post | 14, 2022 | Bulls | | Raptors | |