| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Nets | 77 | Pistons | 113 |
| November | 7, 2021 | Pistons | 99 | Bulls | 92 |
| November | 10, 2021 | 76ers | 89 | Pistons | 87 |
| November | 13, 2021 | Cavaliers | 80 | Pistons | 108 |
| November | 15, 2021 | Celtics | 86 | Pistons | 108 |
| November | 19, 2021 | Pistons | 113 | Celtics | 94 |
| November | 20, 2021 | Pistons | 92 | Nets | 90 |
| November | 23, 2021 | Pistons | 97 | 76ers | 103 |
| November | 25, 2021 | Heat | 94 | Pistons | 78 |
| November | 27, 2021 | Pistons | 118 | Magic | 107 |
| November | 29, 2021 | Pistons | 90 | Hawks | 113 |
| December | 1, 2021 | Hornets | 90 | Pistons | 89 |
| December | 4, 2021 | Pistons | 110 | Raptors | 108 |
| December | 9, 2021 | Cavaliers | 102 | Pistons | 97 |
| December | 11, 2021 | Pistons | 100 | Rockets | 92 |
| December | 13, 2021 | Rockets | 85 | Pistons | 101 |
| December | 16, 2021 | Suns | 94 | Pistons | 123 |
| December | 18, 2021 | Knicks | 83 | Pistons | 101 |
| December | 21, 2021 | Bulls | 83 | Pistons | 96 |
| December | 22, 2021 | Warriors | 103 | Pistons | 116 |
| December | 25, 2021 | Thunder | 129 | Pistons | 127 |
| December | 27, 2021 | Pistons | 111 | Bucks | 103 |
| December | 29, 2021 | 76ers | 97 | Pistons | 112 |
| December | 31, 2021 | Pelicans | 101 | Pistons | 108 |
| January | 1, 2022 | Pistons | 102 | 76ers | 108 |
| January | 3, 2022 | Pistons | 94 | Hornets | 100 |
| January | 6, 2022 | Celtics | 100 | Pistons | 99 |
| January | 8, 2022 | Bucks | 103 | Pistons | 117 |
| January | 11, 2022 | Pistons | 92 | Wolves | 94 |
| January | 12, 2022 | Pistons | 107 | Hornets | 116 |
| January | 14, 2022 | Hawks | 85 | Pistons | 107 |
| January | 16, 2022 | Wizards | 92 | Pistons | 97 |
| January | 18, 2022 | Pistons | 107 | Pacers | 118 |
| January | 20, 2022 | Pistons | 107 | Magic | 103 |
| January | 22, 2022 | Pistons | 117 | Bucks | 102 |
| January | 23, 2022 | Pistons | 100 | Grizzlies | 76 |
| January | 26, 2022 | Jazz | 111 | Pistons | 128 |
| January | 28, 2022 | Spurs | 110 | Pistons | 111 |
| January | 30, 2022 | Pistons | 142 | Lakers | 136 |
| January | 31, 2022 | Pistons | 148 | Kings | 118 |
| February | 2, 2022 | Pistons | 96 | Clippers | 91 |
| February | 5, 2022 | Pistons | 125 | Jazz | 114 |
| February | 7, 2022 | Magic | 100 | Pistons | 113 |
| February | 14, 2022 | Heat | 83 | Pistons | 102 |
| February | 15, 2022 | Kings | 89 | Pistons | 138 |
| February | 17, 2022 | Pistons | 96 | Wizards | 104 |
| February | 19, 2022 | Pistons | 83 | Pelicans | 98 |
| February | 21, 2022 | Pistons | 96 | Mavericks | 83 |
| February | 25, 2022 | Bucks | 115 | Pistons | 125 |
| February | 27, 2022 | Mavericks | 58 | Pistons | 94 |
| March | 1, 2022 | Clippers | 87 | Pistons | 107 |
| March | 4, 2022 | Nuggets | 92 | Pistons | 90 |
| March | 5, 2022 | Pistons | 108 | Knicks | 79 |
| March | 8, 2022 | Knicks | 90 | Pistons | 96 |
| March | 11, 2022 | Wizards | 107 | Pistons | 103 |
| March | 13, 2022 | Pistons | 96 | Celtics | 85 |
| March | 16, 2022 | Pistons | 94 | Hawks | 114 |
| March | 17, 2022 | Pistons | 96 | Heat | 85 |
| March | 19, 2022 | Pacers | 90 | Pistons | 96 |
| March | 21, 2022 | Pistons | 108 | Spurs | 124 |
| March | 24, 2022 | Pistons | 100 | Cavaliers | 95 |
| March | 25, 2022 | Raptors | 99 | Pistons | 104 |
| March | 28, 2022 | Wolves | 88 | Pistons | 112 |
| March | 30, 2022 | Pistons | 97 | Bulls | 93 |
| April | 1, 2022 | Bulls | 96 | Pistons | 109 |
| April | 2, 2022 | Pistons | 113 | Nets | 105 |
| April | 4, 2022 | Pistons | 76 | Heat | 92 |
| April | 6, 2022 | Lakers | 115 | Pistons | 120 |
| April | 8, 2022 | Raptors | 102 | Pistons | 120 |
| April | 9, 2022 | Pistons | 128 | Cavaliers | 108 |
| April | 12, 2022 | Pistons | 109 | Suns | 75 |
| April | 14, 2022 | Pistons | 97 | Trailblazers | 94 |
| April | 15, 2022 | Pistons | 96 | Warriors | 88 |
| April | 17, 2022 | Pistons | 112 | Nuggets | 105 |
| April | 19, 2022 | Magic | 103 | Pistons | 102 |
| April | 21, 2022 | Trailblazers | 86 | Pistons | 106 |
| April | 23, 2022 | Pistons | 148 | Pacers | 139 |
| April | 25, 2022 | Pacers | 117 | Pistons | 108 |
| April | 27, 2022 | Pistons | 110 | Thunder | 107 |
| April | 29, 2022 | Hornets | 95 | Pistons | 117 |
| April | 30, 2022 | Grizzlies | 77 | Pistons | 85 |
| May | 1, 2022 | Pistons | 98 | Knicks | 104 |
| Post | 1, 2022 | Hornets | 86 | Pistons | 114 |
| Post | 2, 2022 | Hornets | 81 | Pistons | 101 |
| Post | 3, 2022 | Pistons | 101 | Hornets | 100 |
| Post | 4, 2022 | Pistons | 109 | Hornets | 86 |
| Post | 5, 2022 | Hornets | | Pistons | |
| Post | 6, 2022 | Pistons | | Hornets | |
| Post | 7, 2022 | Hornets | | Pistons | |
| Post | 8, 2022 | Bucks | 103 | Pistons | 111 |
| Post | 9, 2022 | Bucks | 100 | Pistons | 110 |
| Post | 10, 2022 | Pistons | 111 | Bucks | 113 |
| Post | 11, 2022 | Pistons | 95 | Bucks | 110 |
| Post | 12, 2022 | Bucks | 90 | Pistons | 111 |
| Post | 13, 2022 | Pistons | 121 | Bucks | 125 |
| Post | 14, 2022 | Bucks | 101 | Pistons | 93 |