| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Pelicans | 87 | Rockets | 101 |
| November | 6, 2021 | Kings | 113 | Pelicans | 129 |
| November | 10, 2021 | Clippers | 94 | Pelicans | 111 |
| November | 14, 2021 | Nets | 64 | Pelicans | 97 |
| November | 15, 2021 | Jazz | 98 | Pelicans | 118 |
| November | 18, 2021 | Pelicans | 104 | Nuggets | 91 |
| November | 20, 2021 | Pelicans | 121 | Warriors | 126 |
| November | 21, 2021 | Pelicans | 106 | Trailblazers | 99 |
| November | 23, 2021 | Pelicans | 104 | Spurs | 118 |
| November | 25, 2021 | Pelicans | 109 | Thunder | 121 |
| November | 27, 2021 | Bulls | 114 | Pelicans | 89 |
| November | 30, 2021 | Suns | 91 | Pelicans | 95 |
| December | 2, 2021 | Pelicans | 79 | Raptors | 118 |
| December | 4, 2021 | Pelicans | 103 | Wolves | 101 |
| December | 6, 2021 | Knicks | 72 | Pelicans | 108 |
| December | 7, 2021 | Nuggets | 79 | Pelicans | 98 |
| December | 9, 2021 | Spurs | 103 | Pelicans | 92 |
| December | 12, 2021 | Pelicans | 91 | 76ers | 93 |
| December | 13, 2021 | Pelicans | 94 | Knicks | 72 |
| December | 15, 2021 | Pelicans | 76 | Wizards | 99 |
| December | 17, 2021 | Celtics | 100 | Pelicans | 105 |
| December | 19, 2021 | Wizards | 104 | Pelicans | 94 |
| December | 21, 2021 | Pelicans | 96 | Heat | 107 |
| December | 23, 2021 | Pelicans | 103 | Hornets | 88 |
| December | 25, 2021 | Clippers | 111 | Pelicans | 101 |
| December | 27, 2021 | Mavericks | 120 | Pelicans | 123 |
| December | 29, 2021 | Grizzlies | 81 | Pelicans | 92 |
| December | 31, 2021 | Pelicans | 101 | Pistons | 108 |
| January | 1, 2022 | Pelicans | 66 | Celtics | 81 |
| January | 3, 2022 | Thunder | 121 | Pelicans | 135 |
| January | 7, 2022 | Heat | 111 | Pelicans | 95 |
| January | 10, 2022 | Pelicans | 103 | Bucks | 105 |
| January | 12, 2022 | Pelicans | 91 | Lakers | 113 |
| January | 14, 2022 | Pelicans | 120 | Kings | 113 |
| January | 16, 2022 | Pelicans | 87 | Mavericks | 76 |
| January | 18, 2022 | Mavericks | 78 | Pelicans | 105 |
| January | 19, 2022 | Rockets | 84 | Pelicans | 106 |
| January | 21, 2022 | Wolves | 82 | Pelicans | 72 |
| January | 23, 2022 | Pelicans | 79 | Nets | 84 |
| January | 26, 2022 | Pelicans | 98 | Cavaliers | 102 |
| January | 28, 2022 | Grizzlies | 85 | Pelicans | 84 |
| January | 30, 2022 | Cavaliers | 85 | Pelicans | 100 |
| February | 2, 2022 | Pelicans | 84 | Wolves | 120 |
| February | 5, 2022 | Pelicans | 73 | Clippers | 124 |
| February | 7, 2022 | Pelicans | 99 | Warriors | 117 |
| February | 14, 2022 | Pelicans | 101 | Trailblazers | 90 |
| February | 17, 2022 | Pelicans | 93 | Grizzlies | 102 |
| February | 19, 2022 | Pistons | 83 | Pelicans | 98 |
| February | 20, 2022 | Pelicans | 121 | Thunder | 127 |
| February | 22, 2022 | Spurs | 106 | Pelicans | 109 |
| February | 25, 2022 | Pelicans | 93 | Rockets | 97 |
| February | 26, 2022 | Nuggets | 96 | Pelicans | 119 |
| March | 2, 2022 | Pelicans | 101 | Spurs | 132 |
| March | 4, 2022 | Pacers | 102 | Pelicans | 104 |
| March | 6, 2022 | Pelicans | 97 | Bulls | 93 |
| March | 8, 2022 | Wolves | 91 | Pelicans | 95 |
| March | 9, 2022 | Pelicans | 94 | Grizzlies | 117 |
| March | 12, 2022 | Magic | 119 | Pelicans | 127 |
| March | 14, 2022 | Thunder | 98 | Pelicans | 117 |
| March | 16, 2022 | Pelicans | 96 | Pacers | 125 |
| March | 17, 2022 | Lakers | 116 | Pelicans | 125 |
| March | 19, 2022 | 76ers | 88 | Pelicans | 87 |
| March | 21, 2022 | Pelicans | 124 | Lakers | 120 |
| March | 23, 2022 | Pelicans | 114 | Suns | 84 |
| March | 24, 2022 | Pelicans | 97 | Nuggets | 102 |
| March | 26, 2022 | Pelicans | 124 | Jazz | 144 |
| March | 28, 2022 | Jazz | 115 | Pelicans | 110 |
| March | 30, 2022 | Raptors | 131 | Pelicans | 108 |
| April | 1, 2022 | Pelicans | 87 | Hawks | 85 |
| April | 3, 2022 | Bucks | 121 | Pelicans | 104 |
| April | 6, 2022 | Trailblazers | 79 | Pelicans | 104 |
| April | 7, 2022 | Suns | 96 | Pelicans | 100 |
| April | 9, 2022 | Pelicans | 99 | Mavericks | 119 |
| April | 11, 2022 | Pelicans | 123 | Magic | 128 |
| April | 15, 2022 | Rockets | 90 | Pelicans | 114 |
| April | 17, 2022 | Hawks | 90 | Pelicans | 101 |
| April | 19, 2022 | Kings | 124 | Pelicans | 115 |
| April | 22, 2022 | Lakers | 118 | Pelicans | 121 |
| April | 25, 2022 | Hornets | 110 | Pelicans | 106 |
| April | 27, 2022 | Pelicans | 105 | Suns | 121 |
| April | 29, 2022 | Pelicans | 101 | Kings | 130 |
| April | 30, 2022 | Warriors | 96 | Pelicans | 97 |
| Post | 1, 2022 | Pelicans | 88 | Jazz | 109 |
| Post | 2, 2022 | Pelicans | 100 | Jazz | 109 |
| Post | 3, 2022 | Jazz | 119 | Pelicans | 104 |
| Post | 4, 2022 | Jazz | 112 | Pelicans | 109 |
| Post | 5, 2022 | Pelicans | | Jazz | |
| Post | 6, 2022 | Jazz | | Pelicans | |
| Post | 7, 2022 | Pelicans | | Jazz | |