| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Mavericks | 88 | Suns | 100 |
| November | 7, 2021 | Wolves | 108 | Mavericks | 112 |
| November | 9, 2021 | Bulls | 109 | Mavericks | 106 |
| November | 11, 2021 | Mavericks | 106 | Hawks | 124 |
| November | 14, 2021 | Mavericks | 106 | Raptors | 120 |
| November | 17, 2021 | Jazz | 105 | Mavericks | 109 |
| November | 18, 2021 | Mavericks | 99 | Spurs | 114 |
| November | 20, 2021 | Mavericks | 108 | Lakers | 99 |
| November | 22, 2021 | Knicks | 87 | Mavericks | 98 |
| November | 26, 2021 | Wizards | 109 | Mavericks | 95 |
| November | 27, 2021 | Mavericks | 90 | Jazz | 96 |
| November | 30, 2021 | Thunder | 120 | Mavericks | 112 |
| December | 2, 2021 | Mavericks | 100 | Bulls | 118 |
| December | 4, 2021 | Jazz | 123 | Mavericks | 105 |
| December | 7, 2021 | Warriors | 99 | Mavericks | 114 |
| December | 9, 2021 | Mavericks | 84 | Grizzlies | 100 |
| December | 11, 2021 | Nets | 86 | Mavericks | 116 |
| December | 15, 2021 | Celtics | 95 | Mavericks | 118 |
| December | 19, 2021 | Mavericks | 93 | Rockets | 97 |
| December | 21, 2021 | Mavericks | 121 | Lakers | 114 |
| December | 23, 2021 | Clippers | 126 | Mavericks | 111 |
| December | 26, 2021 | Trailblazers | 95 | Mavericks | 118 |
| December | 27, 2021 | Mavericks | 120 | Pelicans | 123 |
| December | 30, 2021 | Rockets | 80 | Mavericks | 100 |
| January | 1, 2022 | Magic | 91 | Mavericks | 113 |
| January | 3, 2022 | Hawks | 98 | Mavericks | 88 |
| January | 4, 2022 | Mavericks | 119 | Suns | 94 |
| January | 7, 2022 | Kings | 95 | Mavericks | 109 |
| January | 9, 2022 | Mavericks | 107 | Nuggets | 118 |
| January | 11, 2022 | Mavericks | 92 | Clippers | 99 |
| January | 13, 2022 | Mavericks | 106 | Warriors | 115 |
| January | 14, 2022 | Mavericks | 103 | Trailblazers | 101 |
| January | 16, 2022 | Pelicans | 87 | Mavericks | 76 |
| January | 18, 2022 | Mavericks | 78 | Pelicans | 105 |
| January | 20, 2022 | Thunder | 116 | Mavericks | 124 |
| January | 21, 2022 | Mavericks | 105 | Thunder | 126 |
| January | 23, 2022 | Mavericks | 90 | Hornets | 118 |
| January | 25, 2022 | Mavericks | 108 | Celtics | 100 |
| January | 26, 2022 | Mavericks | 88 | 76ers | 103 |
| January | 28, 2022 | Lakers | 108 | Mavericks | 109 |
| January | 30, 2022 | Suns | 101 | Mavericks | 98 |
| February | 1, 2022 | Mavericks | 113 | Wolves | 137 |
| February | 4, 2022 | Warriors | 125 | Mavericks | 114 |
| February | 7, 2022 | Spurs | 101 | Mavericks | 121 |
| February | 15, 2022 | Mavericks | 95 | Pacers | 104 |
| February | 17, 2022 | Mavericks | 110 | Bucks | 114 |
| February | 18, 2022 | Clippers | 123 | Mavericks | 84 |
| February | 21, 2022 | Pistons | 96 | Mavericks | 83 |
| February | 23, 2022 | Raptors | 116 | Mavericks | 92 |
| February | 26, 2022 | Mavericks | 72 | Knicks | 81 |
| February | 27, 2022 | Mavericks | 58 | Pistons | 94 |
| March | 1, 2022 | Mavericks | 98 | Cavaliers | 118 |
| March | 6, 2022 | Hornets | 97 | Mavericks | 107 |
| March | 8, 2022 | Bucks | 91 | Mavericks | 114 |
| March | 10, 2022 | Trailblazers | 73 | Mavericks | 107 |
| March | 11, 2022 | Mavericks | 88 | Rockets | 96 |
| March | 13, 2022 | Heat | 106 | Mavericks | 115 |
| March | 16, 2022 | Nuggets | 96 | Mavericks | 93 |
| March | 17, 2022 | Mavericks | 96 | Jazz | 114 |
| March | 19, 2022 | Mavericks | 98 | Clippers | 125 |
| March | 21, 2022 | Pacers | 122 | Mavericks | 81 |
| March | 24, 2022 | Grizzlies | 111 | Mavericks | 99 |
| March | 26, 2022 | Mavericks | 76 | Nets | 91 |
| March | 28, 2022 | Mavericks | 82 | Wizards | 116 |
| March | 30, 2022 | Mavericks | 118 | Magic | 134 |
| April | 1, 2022 | Rockets | 70 | Mavericks | 95 |
| April | 3, 2022 | Spurs | 109 | Mavericks | 94 |
| April | 5, 2022 | Mavericks | 65 | Nuggets | 108 |
| April | 7, 2022 | Cavaliers | 108 | Mavericks | 98 |
| April | 9, 2022 | Pelicans | 99 | Mavericks | 119 |
| April | 11, 2022 | Mavericks | 97 | Trailblazers | 106 |
| April | 12, 2022 | Mavericks | 105 | Kings | 113 |
| April | 14, 2022 | Mavericks | 79 | Warriors | 99 |
| April | 17, 2022 | Kings | 121 | Mavericks | 112 |
| April | 19, 2022 | Mavericks | 106 | Heat | 99 |
| April | 22, 2022 | Mavericks | 103 | Thunder | 89 |
| April | 23, 2022 | 76ers | 93 | Mavericks | 125 |
| April | 25, 2022 | Wolves | 112 | Mavericks | 104 |
| April | 27, 2022 | Grizzlies | 95 | Mavericks | 115 |
| April | 29, 2022 | Mavericks | 93 | Grizzlies | 116 |
| April | 30, 2022 | Suns | 105 | Mavericks | 99 |
| May | 1, 2022 | Mavericks | 106 | Spurs | 117 |