| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Heat | 112 | Magic | 122 |
| November | 6, 2021 | Hornets | 92 | Magic | 114 |
| November | 7, 2021 | Magic | 122 | 76ers | 115 |
| November | 9, 2021 | Magic | 119 | Celtics | 117 |
| November | 13, 2021 | Trailblazers | 99 | Magic | 117 |
| November | 16, 2021 | Magic | 103 | Bucks | 115 |
| November | 19, 2021 | Kings | 131 | Magic | 130 |
| November | 22, 2021 | Clippers | 109 | Magic | 124 |
| November | 24, 2021 | Magic | 107 | Spurs | 134 |
| November | 25, 2021 | Cavaliers | 112 | Magic | 138 |
| November | 27, 2021 | Pistons | 118 | Magic | 107 |
| November | 29, 2021 | Wizards | 125 | Magic | 119 |
| December | 1, 2021 | Magic | 105 | Knicks | 93 |
| December | 2, 2021 | Magic | 111 | Wizards | 118 |
| December | 4, 2021 | 76ers | 99 | Magic | 125 |
| December | 7, 2021 | Lakers | 121 | Magic | 133 |
| December | 8, 2021 | Knicks | 91 | Magic | 108 |
| December | 10, 2021 | Raptors | 108 | Magic | 92 |
| December | 14, 2021 | Magic | 119 | Nuggets | 118 |
| December | 16, 2021 | Magic | 117 | Lakers | 113 |
| December | 17, 2021 | Magic | 117 | Warriors | 127 |
| December | 19, 2021 | Magic | 88 | Trailblazers | 107 |
| December | 21, 2021 | Magic | 141 | Suns | 124 |
| December | 26, 2021 | Magic | 122 | Heat | 124 |
| December | 27, 2021 | Nuggets | 122 | Magic | 119 |
| December | 29, 2021 | Pacers | 124 | Magic | 128 |
| January | 1, 2022 | Magic | 91 | Mavericks | 113 |
| January | 4, 2022 | Bulls | 112 | Magic | 132 |
| January | 6, 2022 | Jazz | 98 | Magic | 111 |
| January | 10, 2022 | Spurs | 100 | Magic | 106 |
| January | 12, 2022 | Magic | 114 | Bulls | 126 |
| January | 14, 2022 | Heat | 104 | Magic | 100 |
| January | 16, 2022 | Suns | 108 | Magic | 121 |
| January | 18, 2022 | Raptors | 113 | Magic | 124 |
| January | 20, 2022 | Pistons | 107 | Magic | 103 |
| January | 21, 2022 | Magic | 94 | Hornets | 90 |
| January | 23, 2022 | Magic | 115 | Bulls | 111 |
| January | 25, 2022 | Magic | 98 | Wolves | 113 |
| January | 27, 2022 | Magic | 106 | Clippers | 116 |
| January | 28, 2022 | Magic | 132 | Kings | 148 |
| January | 30, 2022 | Magic | 122 | Jazz | 136 |
| February | 2, 2022 | Celtics | 94 | Magic | 108 |
| February | 4, 2022 | Rockets | 111 | Magic | 122 |
| February | 7, 2022 | Magic | 100 | Pistons | 113 |
| February | 14, 2022 | Nets | 99 | Magic | 98 |
| February | 15, 2022 | Bucks | 103 | Magic | 118 |
| February | 17, 2022 | Magic | 78 | Hawks | 103 |
| February | 19, 2022 | Magic | 86 | Nets | 104 |
| February | 21, 2022 | Wizards | 125 | Magic | 115 |
| February | 23, 2022 | Magic | 126 | Rockets | 123 |
| February | 25, 2022 | Thunder | 135 | Magic | 132 |
| February | 27, 2022 | Pacers | 116 | Magic | 114 |
| March | 1, 2022 | Nets | 97 | Magic | 113 |
| March | 5, 2022 | Magic | 111 | Thunder | 108 |
| March | 7, 2022 | Wolves | 110 | Magic | 118 |
| March | 9, 2022 | Magic | 117 | Bucks | 121 |
| March | 10, 2022 | Magic | 119 | Hawks | 110 |
| March | 12, 2022 | Magic | 119 | Pelicans | 127 |
| March | 14, 2022 | Hornets | 122 | Magic | 120 |
| March | 16, 2022 | Bulls | 110 | Magic | 122 |
| March | 18, 2022 | Magic | 98 | Raptors | 128 |
| March | 20, 2022 | Magic | 92 | Knicks | 94 |
| March | 22, 2022 | Warriors | 104 | Magic | 107 |
| March | 24, 2022 | Magic | 108 | Pacers | 105 |
| March | 25, 2022 | Magic | 115 | Cavaliers | 126 |
| March | 27, 2022 | Magic | 132 | 76ers | 114 |
| March | 30, 2022 | Mavericks | 118 | Magic | 134 |
| April | 1, 2022 | Magic | 120 | Grizzlies | 117 |
| April | 4, 2022 | Magic | 111 | Wizards | 125 |
| April | 5, 2022 | Cavaliers | 131 | Magic | 118 |
| April | 8, 2022 | Hawks | 106 | Magic | 70 |
| April | 11, 2022 | Pelicans | 123 | Magic | 128 |
| April | 13, 2022 | Grizzlies | 121 | Magic | 106 |
| April | 16, 2022 | 76ers | 110 | Magic | 132 |
| April | 17, 2022 | Magic | 111 | Heat | 125 |
| April | 19, 2022 | Magic | 103 | Pistons | 102 |
| April | 21, 2022 | Magic | 91 | Pacers | 111 |
| April | 23, 2022 | Magic | 99 | Raptors | 122 |
| April | 25, 2022 | Knicks | 90 | Magic | 100 |
| April | 27, 2022 | Hawks | 99 | Magic | 91 |
| April | 29, 2022 | Magic | 125 | Celtics | 124 |
| May | 1, 2022 | Magic | 103 | Hornets | 114 |