| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Hawks | 110 | Knicks | 69 |
| November | 6, 2021 | Knicks | 88 | Nets | 93 |
| November | 7, 2021 | Celtics | 96 | Knicks | 91 |
| November | 9, 2021 | Knicks | 109 | Bucks | 123 |
| November | 11, 2021 | Knicks | 78 | Heat | 77 |
| November | 14, 2021 | Warriors | 119 | Knicks | 123 |
| November | 18, 2021 | Nets | 94 | Knicks | 79 |
| November | 20, 2021 | Pacers | 103 | Knicks | 96 |
| November | 22, 2021 | Knicks | 87 | Mavericks | 98 |
| November | 24, 2021 | Knicks | 78 | Wizards | 99 |
| November | 25, 2021 | Bulls | 92 | Knicks | 96 |
| November | 27, 2021 | Knicks | 79 | Hawks | 91 |
| November | 30, 2021 | Knicks | 81 | Raptors | 104 |
| December | 1, 2021 | Magic | 105 | Knicks | 93 |
| December | 4, 2021 | Knicks | 110 | Thunder | 115 |
| December | 6, 2021 | Knicks | 72 | Pelicans | 108 |
| December | 8, 2021 | Knicks | 91 | Magic | 108 |
| December | 10, 2021 | Trailblazers | 87 | Knicks | 89 |
| December | 12, 2021 | Knicks | 70 | Celtics | 91 |
| December | 13, 2021 | Pelicans | 94 | Knicks | 72 |
| December | 16, 2021 | Knicks | 78 | Grizzlies | 102 |
| December | 18, 2021 | Knicks | 83 | Pistons | 101 |
| December | 19, 2021 | Knicks | 80 | 76ers | 83 |
| December | 22, 2021 | Bucks | 112 | Knicks | 98 |
| December | 25, 2021 | Wizards | 101 | Knicks | 79 |
| December | 28, 2021 | Knicks | 75 | Celtics | 96 |
| December | 30, 2021 | Nets | 85 | Knicks | 89 |
| December | 31, 2021 | Hornets | 105 | Knicks | 95 |
| January | 3, 2022 | Knicks | 86 | Cavaliers | 107 |
| January | 5, 2022 | Knicks | 81 | Hornets | 94 |
| January | 7, 2022 | Knicks | 86 | Pacers | 116 |
| January | 8, 2022 | Suns | 94 | Knicks | 90 |
| January | 10, 2022 | Knicks | 87 | 76ers | 109 |
| January | 12, 2022 | Hawks | 77 | Knicks | 78 |
| January | 15, 2022 | Bucks | 112 | Knicks | 98 |
| January | 17, 2022 | Knicks | 103 | Bucks | 122 |
| January | 19, 2022 | Knicks | 85 | Jazz | 115 |
| January | 22, 2022 | Knicks | 94 | Nuggets | 82 |
| January | 25, 2022 | Knicks | 97 | Lakers | 117 |
| January | 28, 2022 | Knicks | 88 | Trailblazers | 103 |
| January | 29, 2022 | Knicks | 87 | Warriors | 108 |
| February | 1, 2022 | Pacers | 110 | Knicks | 98 |
| February | 4, 2022 | 76ers | 98 | Knicks | 86 |
| February | 13, 2022 | Knicks | 72 | Wizards | 106 |
| February | 17, 2022 | Thunder | 124 | Knicks | 123 |
| February | 19, 2022 | Rockets | 82 | Knicks | 89 |
| February | 21, 2022 | Knicks | 58 | Nets | 85 |
| February | 23, 2022 | Heat | 82 | Knicks | 103 |
| February | 24, 2022 | Knicks | 87 | Hornets | 91 |
| February | 26, 2022 | Mavericks | 72 | Knicks | 81 |
| February | 28, 2022 | Celtics | 77 | Knicks | 81 |
| March | 3, 2022 | Grizzlies | 75 | Knicks | 82 |
| March | 5, 2022 | Pistons | 108 | Knicks | 79 |
| March | 8, 2022 | Knicks | 90 | Pistons | 96 |
| March | 9, 2022 | Raptors | 108 | Knicks | 84 |
| March | 11, 2022 | Knicks | 112 | Cavaliers | 111 |
| March | 13, 2022 | 76ers | 75 | Knicks | 87 |
| March | 14, 2022 | Knicks | 80 | Hawks | 93 |
| March | 16, 2022 | Wolves | 87 | Knicks | 96 |
| March | 18, 2022 | Spurs | 111 | Knicks | 104 |
| March | 20, 2022 | Magic | 92 | Knicks | 94 |
| March | 22, 2022 | Cavaliers | 109 | Knicks | 98 |
| March | 25, 2022 | Knicks | 90 | Clippers | 98 |
| March | 26, 2022 | Knicks | 105 | Kings | 112 |
| March | 28, 2022 | Knicks | 88 | Suns | 85 |
| March | 31, 2022 | Kings | 118 | Knicks | 117 |
| April | 1, 2022 | Knicks | 81 | Wolves | 82 |
| April | 3, 2022 | Knicks | 79 | Pacers | 123 |
| April | 6, 2022 | Knicks | 87 | Spurs | 107 |
| April | 8, 2022 | Lakers | 112 | Knicks | 104 |
| April | 9, 2022 | Knicks | 57 | Raptors | 76 |
| April | 11, 2022 | Jazz | 95 | Knicks | 80 |
| April | 13, 2022 | Nuggets | 96 | Knicks | 83 |
| April | 15, 2022 | Clippers | 84 | Knicks | 89 |
| April | 19, 2022 | Raptors | 89 | Knicks | 84 |
| April | 21, 2022 | Heat | 79 | Knicks | 97 |
| April | 23, 2022 | Bulls | 115 | Knicks | 100 |
| April | 25, 2022 | Knicks | 90 | Magic | 100 |
| April | 27, 2022 | Knicks | 102 | Rockets | 95 |
| April | 29, 2022 | Wizards | 104 | Knicks | 92 |
| April | 30, 2022 | Knicks | 88 | Bulls | 93 |
| May | 1, 2022 | Pistons | 98 | Knicks | 104 |