| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Nuggets | 115 | Clippers | 84 |
| November | 6, 2021 | Thunder | 77 | Clippers | 143 |
| November | 8, 2021 | Rockets | 103 | Clippers | 101 |
| November | 10, 2021 | Clippers | 94 | Pelicans | 111 |
| November | 14, 2021 | Clippers | 90 | Rockets | 93 |
| November | 17, 2021 | Wizards | 105 | Clippers | 115 |
| November | 19, 2021 | Clippers | 107 | Thunder | 115 |
| November | 21, 2021 | Clippers | 99 | 76ers | 98 |
| November | 22, 2021 | Clippers | 109 | Magic | 124 |
| November | 25, 2021 | Wolves | 90 | Clippers | 99 |
| November | 28, 2021 | Clippers | 100 | Trailblazers | 116 |
| November | 30, 2021 | Bucks | 102 | Clippers | 123 |
| December | 2, 2021 | Warriors | 122 | Clippers | 128 |
| December | 5, 2021 | Spurs | 115 | Clippers | 116 |
| December | 7, 2021 | Clippers | 76 | Nets | 88 |
| December | 9, 2021 | Clippers | 101 | Hawks | 110 |
| December | 10, 2021 | Clippers | 106 | Wizards | 108 |
| December | 13, 2021 | Grizzlies | 117 | Clippers | 106 |
| December | 16, 2021 | Clippers | 103 | Trailblazers | 122 |
| December | 19, 2021 | Suns | 107 | Clippers | 135 |
| December | 20, 2021 | Clippers | 119 | Kings | 112 |
| December | 23, 2021 | Clippers | 126 | Mavericks | 111 |
| December | 25, 2021 | Clippers | 111 | Pelicans | 101 |
| December | 27, 2021 | Clippers | 106 | Grizzlies | 115 |
| December | 30, 2021 | Heat | 95 | Clippers | 100 |
| January | 1, 2022 | Clippers | 109 | Suns | 118 |
| January | 2, 2022 | Raptors | 118 | Clippers | 80 |
| January | 4, 2022 | Clippers | 133 | Spurs | 138 |
| January | 6, 2022 | Clippers | 117 | Thunder | 116 |
| January | 8, 2022 | Trailblazers | 114 | Clippers | 100 |
| January | 11, 2022 | Mavericks | 92 | Clippers | 99 |
| January | 13, 2022 | Nuggets | 96 | Clippers | 106 |
| January | 14, 2022 | Clippers | 122 | Warriors | 111 |
| January | 16, 2022 | Kings | 99 | Clippers | 125 |
| January | 18, 2022 | Clippers | 116 | Lakers | 120 |
| January | 19, 2022 | Spurs | 123 | Clippers | 127 |
| January | 22, 2022 | 76ers | 98 | Clippers | 125 |
| January | 25, 2022 | Clippers | 113 | Suns | 120 |
| January | 27, 2022 | Magic | 106 | Clippers | 116 |
| January | 29, 2022 | Hornets | 93 | Clippers | 104 |
| January | 31, 2022 | Clippers | 119 | Nuggets | 135 |
| February | 2, 2022 | Pistons | 96 | Clippers | 91 |
| February | 5, 2022 | Pelicans | 73 | Clippers | 124 |
| February | 7, 2022 | Jazz | 104 | Clippers | 106 |
| February | 14, 2022 | Warriors | 107 | Clippers | 111 |
| February | 16, 2022 | Clippers | 106 | Spurs | 136 |
| February | 18, 2022 | Clippers | 123 | Mavericks | 84 |
| February | 19, 2022 | Clippers | 122 | Heat | 99 |
| February | 21, 2022 | Clippers | 99 | Bulls | 116 |
| February | 23, 2022 | Kings | 108 | Clippers | 131 |
| February | 24, 2022 | Hawks | 96 | Clippers | 86 |
| February | 27, 2022 | Lakers | 87 | Clippers | 137 |
| March | 1, 2022 | Clippers | 87 | Pistons | 107 |
| March | 3, 2022 | Clippers | 128 | Raptors | 116 |
| March | 5, 2022 | Clippers | 102 | Hornets | 107 |
| March | 7, 2022 | Clippers | 88 | Pacers | 109 |
| March | 9, 2022 | Clippers | 97 | Celtics | 102 |
| March | 11, 2022 | Clippers | 95 | Wolves | 103 |
| March | 13, 2022 | Suns | 98 | Clippers | 115 |
| March | 16, 2022 | Clippers | 92 | Grizzlies | 120 |
| March | 18, 2022 | Clippers | 92 | Nuggets | 110 |
| March | 19, 2022 | Mavericks | 98 | Clippers | 125 |
| March | 21, 2022 | Clippers | 110 | Jazz | 117 |
| March | 23, 2022 | Clippers | 133 | Kings | 117 |
| March | 25, 2022 | Knicks | 90 | Clippers | 98 |
| March | 26, 2022 | Clippers | 128 | Lakers | 107 |
| March | 30, 2022 | Thunder | 139 | Clippers | 112 |
| April | 2, 2022 | Celtics | 101 | Clippers | 110 |
| April | 3, 2022 | Trailblazers | 82 | Clippers | 119 |
| April | 6, 2022 | Bulls | 108 | Clippers | 100 |
| April | 8, 2022 | Nets | 93 | Clippers | 81 |
| April | 10, 2022 | Pacers | 96 | Clippers | 126 |
| April | 13, 2022 | Clippers | 118 | Cavaliers | 116 |
| April | 15, 2022 | Clippers | 84 | Knicks | 89 |
| April | 17, 2022 | Clippers | 100 | Wolves | 98 |
| April | 19, 2022 | Clippers | 111 | Bucks | 114 |
| April | 21, 2022 | Cavaliers | 115 | Clippers | 122 |
| April | 22, 2022 | Grizzlies | 111 | Clippers | 115 |
| April | 25, 2022 | Rockets | 99 | Clippers | 109 |
| April | 27, 2022 | Lakers | 87 | Clippers | 126 |
| April | 29, 2022 | Clippers | 98 | Warriors | 107 |
| May | 1, 2022 | Jazz | 124 | Clippers | 112 |
| Post | 1, 2022 | Nuggets | 116 | Clippers | 120 |
| Post | 2, 2022 | Nuggets | 100 | Clippers | 127 |
| Post | 3, 2022 | Clippers | 91 | Nuggets | 104 |
| Post | 4, 2022 | Clippers | 102 | Nuggets | 111 |
| Post | 5, 2022 | Nuggets | 111 | Clippers | 83 |
| Post | 6, 2022 | Clippers | 100 | Nuggets | 98 |
| Post | 7, 2022 | Nuggets | 97 | Clippers | 122 |
| Post | 8, 2022 | Clippers | 90 | Jazz | 123 |
| Post | 9, 2022 | Clippers | 99 | Jazz | 102 |
| Post | 10, 2022 | Jazz | 117 | Clippers | 129 |
| Post | 11, 2022 | Jazz | 93 | Clippers | 96 |
| Post | 12, 2022 | Clippers | 108 | Jazz | 101 |
| Post | 13, 2022 | Jazz | 122 | Clippers | 110 |
| Post | 14, 2022 | Clippers | 94 | Jazz | 120 |