| month | day | visitor | score | home | score |
|---|
| November | 5, 2021 | Bulls | 98 | 76ers | 79 |
| November | 7, 2021 | Pistons | 99 | Bulls | 92 |
| November | 9, 2021 | Bulls | 109 | Mavericks | 106 |
| November | 11, 2021 | Hornets | 98 | Bulls | 101 |
| November | 14, 2021 | Bulls | 88 | Hornets | 109 |
| November | 15, 2021 | Bulls | 78 | Hawks | 99 |
| November | 18, 2021 | Warriors | 109 | Bulls | 113 |
| November | 20, 2021 | Nuggets | 90 | Bulls | 112 |
| November | 22, 2021 | Pacers | 98 | Bulls | 106 |
| November | 23, 2021 | Rockets | 78 | Bulls | 98 |
| November | 25, 2021 | Bulls | 92 | Knicks | 96 |
| November | 27, 2021 | Bulls | 114 | Pelicans | 89 |
| November | 30, 2021 | Cavaliers | 84 | Bulls | 110 |
| December | 2, 2021 | Mavericks | 100 | Bulls | 118 |
| December | 4, 2021 | Bulls | 126 | Celtics | 97 |
| December | 6, 2021 | Bulls | 96 | Bucks | 114 |
| December | 7, 2021 | Raptors | 113 | Bulls | 105 |
| December | 12, 2021 | Suns | 111 | Bulls | 123 |
| December | 14, 2021 | Heat | 99 | Bulls | 107 |
| December | 15, 2021 | Bulls | 83 | Wolves | 108 |
| December | 17, 2021 | Spurs | 110 | Bulls | 128 |
| December | 19, 2021 | Bulls | 116 | Bucks | 118 |
| December | 21, 2021 | Bulls | 83 | Pistons | 96 |
| December | 22, 2021 | Bulls | 92 | Rockets | 102 |
| December | 26, 2021 | Bulls | 89 | Pacers | 125 |
| December | 29, 2021 | Thunder | 108 | Bulls | 136 |
| December | 30, 2021 | Celtics | 83 | Bulls | 106 |
| January | 1, 2022 | Kings | 124 | Bulls | 117 |
| January | 4, 2022 | Bulls | 112 | Magic | 132 |
| January | 6, 2022 | Bulls | 127 | Spurs | 123 |
| January | 8, 2022 | Bulls | 111 | Thunder | 121 |
| January | 10, 2022 | Nets | 88 | Bulls | 101 |
| January | 12, 2022 | Magic | 114 | Bulls | 126 |
| January | 14, 2022 | Bulls | 95 | Cavaliers | 96 |
| January | 16, 2022 | Wolves | 93 | Bulls | 95 |
| January | 18, 2022 | Bulls | 95 | Wizards | 107 |
| January | 20, 2022 | Bulls | 109 | Raptors | 106 |
| January | 23, 2022 | Magic | 115 | Bulls | 111 |
| January | 25, 2022 | Pacers | 114 | Bulls | 102 |
| January | 27, 2022 | Nets | 79 | Bulls | 88 |
| January | 30, 2022 | Bulls | 99 | Trailblazers | 106 |
| February | 1, 2022 | Bulls | 99 | Warriors | 110 |
| February | 2, 2022 | Bulls | 132 | Jazz | 127 |
| February | 6, 2022 | Bulls | 118 | Lakers | 107 |
| February | 13, 2022 | Bulls | 112 | Nuggets | 101 |
| February | 15, 2022 | Heat | 112 | Bulls | 117 |
| February | 17, 2022 | Bulls | 122 | Cavaliers | 97 |
| February | 19, 2022 | Hawks | 72 | Bulls | 90 |
| February | 21, 2022 | Clippers | 99 | Bulls | 116 |
| February | 23, 2022 | Cavaliers | 117 | Bulls | 144 |
| February | 25, 2022 | Bulls | 88 | Nets | 74 |
| February | 26, 2022 | Bulls | 100 | Heat | 83 |
| March | 1, 2022 | Bulls | 97 | Hornets | 93 |
| March | 6, 2022 | Pelicans | 97 | Bulls | 93 |
| March | 8, 2022 | Bulls | 98 | Nets | 91 |
| March | 9, 2022 | Wizards | 102 | Bulls | 98 |
| March | 11, 2022 | Bucks | 119 | Bulls | 113 |
| March | 13, 2022 | Grizzlies | 104 | Bulls | 113 |
| March | 16, 2022 | Bulls | 110 | Magic | 122 |
| March | 17, 2022 | Celtics | 87 | Bulls | 107 |
| March | 19, 2022 | Bucks | 143 | Bulls | 138 |
| March | 21, 2022 | Bulls | 100 | Grizzlies | 115 |
| March | 23, 2022 | Bulls | 99 | Hawks | 92 |
| March | 25, 2022 | Hawks | 110 | Bulls | 102 |
| March | 27, 2022 | Bulls | 100 | Pacers | 85 |
| March | 28, 2022 | 76ers | 79 | Bulls | 97 |
| March | 30, 2022 | Pistons | 97 | Bulls | 93 |
| April | 1, 2022 | Bulls | 96 | Pistons | 109 |
| April | 3, 2022 | Lakers | 112 | Bulls | 119 |
| April | 6, 2022 | Bulls | 108 | Clippers | 100 |
| April | 8, 2022 | Bulls | 106 | Kings | 97 |
| April | 9, 2022 | Bulls | 102 | Suns | 71 |
| April | 11, 2022 | Wizards | 96 | Bulls | 83 |
| April | 14, 2022 | Jazz | 103 | Bulls | 102 |
| April | 17, 2022 | Bulls | 121 | Raptors | 106 |
| April | 18, 2022 | Trailblazers | 89 | Bulls | 93 |
| April | 21, 2022 | Raptors | 107 | Bulls | 100 |
| April | 23, 2022 | Bulls | 115 | Knicks | 100 |
| April | 25, 2022 | Bulls | 77 | Wizards | 107 |
| April | 28, 2022 | 76ers | 102 | Bulls | 105 |
| April | 30, 2022 | Knicks | 88 | Bulls | 93 |
| May | 1, 2022 | Bulls | 130 | 76ers | 105 |
| Post | 1, 2022 | Bulls | 83 | Wizards | 84 |
| Post | 2, 2022 | Bulls | 108 | Wizards | 88 |
| Post | 3, 2022 | Wizards | 83 | Bulls | 85 |
| Post | 4, 2022 | Wizards | 101 | Bulls | 104 |
| Post | 5, 2022 | Bulls | 91 | Wizards | 89 |
| Post | 6, 2022 | Wizards | | Bulls | |
| Post | 7, 2022 | Bulls | | Wizards | |
| Post | 8, 2022 | Bulls | 105 | Raptors | 93 |
| Post | 9, 2022 | Bulls | 99 | Raptors | 86 |
| Post | 10, 2022 | Raptors | 95 | Bulls | 120 |
| Post | 11, 2022 | Raptors | 96 | Bulls | 98 |
| Post | 12, 2022 | Bulls | | Raptors | |
| Post | 13, 2022 | Raptors | | Bulls | |
| Post | 14, 2022 | Bulls | | Raptors | |
| Post | 15, 2022 | Bulls | 100 | Bucks | 127 |
| Post | 16, 2022 | Bulls | 115 | Bucks | 122 |
| Post | 17, 2022 | Bucks | 89 | Bulls | 108 |
| Post | 18, 2022 | Bucks | 109 | Bulls | 112 |
| Post | 19, 2022 | Bulls | 95 | Bucks | 111 |
| Post | 20, 2022 | Bucks | 99 | Bulls | 115 |
| Post | 21, 2022 | Bulls | 111 | Bucks | 92 |
| Post | 22, 2022 | Bulls | 107 | Spurs | 110 |
| Post | 23, 2022 | Bulls | 75 | Spurs | 113 |
| Post | 24, 2022 | Spurs | 117 | Bulls | 111 |
| Post | 25, 2022 | Spurs | 79 | Bulls | 112 |
| Post | 26, 2022 | Spurs | 109 | Bulls | 91 |