| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | 76ers | 110 | Celtics | 121 |
| November | 5, 2021 | Bulls | 98 | 76ers | 79 |
| November | 7, 2021 | Magic | 122 | 76ers | 115 |
| November | 10, 2021 | 76ers | 89 | Pistons | 87 |
| November | 12, 2021 | 76ers | 96 | Bucks | 117 |
| November | 16, 2021 | Hornets | 82 | 76ers | 92 |
| November | 18, 2021 | Hawks | 91 | 76ers | 86 |
| November | 19, 2021 | 76ers | 114 | Raptors | 112 |
| November | 21, 2021 | Clippers | 99 | 76ers | 98 |
| November | 23, 2021 | Pistons | 97 | 76ers | 103 |
| November | 24, 2021 | 76ers | 79 | Nets | 96 |
| November | 27, 2021 | 76ers | 94 | Pacers | 92 |
| November | 29, 2021 | Hornets | 92 | 76ers | 75 |
| November | 30, 2021 | 76ers | 79 | Grizzlies | 105 |
| December | 2, 2021 | 76ers | 87 | Heat | 90 |
| December | 4, 2021 | 76ers | 99 | Magic | 125 |
| December | 6, 2021 | Jazz | 123 | 76ers | 93 |
| December | 7, 2021 | 76ers | 75 | Hornets | 108 |
| December | 9, 2021 | Suns | 97 | 76ers | 139 |
| December | 12, 2021 | Pelicans | 91 | 76ers | 93 |
| December | 13, 2021 | Cavaliers | 127 | 76ers | 94 |
| December | 16, 2021 | 76ers | 86 | Nets | 88 |
| December | 19, 2021 | Knicks | 80 | 76ers | 83 |
| December | 21, 2021 | Wizards | 86 | 76ers | 106 |
| December | 23, 2021 | Grizzlies | 113 | 76ers | 99 |
| December | 27, 2021 | 76ers | 100 | Raptors | 101 |
| December | 29, 2021 | 76ers | 97 | Pistons | 112 |
| January | 1, 2022 | Pistons | 102 | 76ers | 108 |
| January | 3, 2022 | Nets | 87 | 76ers | 95 |
| January | 5, 2022 | Pacers | 122 | 76ers | 112 |
| January | 7, 2022 | 76ers | 107 | Cavaliers | 124 |
| January | 8, 2022 | 76ers | 107 | Spurs | 132 |
| January | 10, 2022 | Knicks | 87 | 76ers | 109 |
| January | 13, 2022 | Raptors | 111 | 76ers | 106 |
| January | 15, 2022 | 76ers | 108 | Celtics | 106 |
| January | 17, 2022 | 76ers | 105 | Jazz | 108 |
| January | 20, 2022 | 76ers | 103 | Trailblazers | 104 |
| January | 22, 2022 | 76ers | 98 | Clippers | 125 |
| January | 23, 2022 | 76ers | 82 | Suns | 86 |
| January | 26, 2022 | Mavericks | 88 | 76ers | 103 |
| January | 29, 2022 | Wizards | 88 | 76ers | 100 |
| January | 30, 2022 | 76ers | 85 | Wizards | 104 |
| February | 1, 2022 | Hawks | 82 | 76ers | 79 |
| February | 4, 2022 | 76ers | 98 | Knicks | 86 |
| February | 6, 2022 | Wolves | 104 | 76ers | 98 |
| February | 13, 2022 | 76ers | 96 | Pacers | 104 |
| February | 15, 2022 | Thunder | 107 | 76ers | 118 |
| February | 17, 2022 | Rockets | 99 | 76ers | 100 |
| February | 19, 2022 | Spurs | 108 | 76ers | 114 |
| February | 22, 2022 | 76ers | 78 | Nuggets | 105 |
| February | 25, 2022 | 76ers | 121 | Lakers | 133 |
| February | 27, 2022 | 76ers | 100 | Warriors | 113 |
| March | 2, 2022 | 76ers | 98 | Kings | 112 |
| March | 5, 2022 | Raptors | 110 | 76ers | 102 |
| March | 8, 2022 | Nuggets | 106 | 76ers | 86 |
| March | 10, 2022 | Lakers | 112 | 76ers | 119 |
| March | 12, 2022 | Celtics | 81 | 76ers | 95 |
| March | 13, 2022 | 76ers | 75 | Knicks | 87 |
| March | 15, 2022 | Heat | 105 | 76ers | 118 |
| March | 17, 2022 | Trailblazers | 74 | 76ers | 111 |
| March | 19, 2022 | 76ers | 88 | Pelicans | 87 |
| March | 22, 2022 | 76ers | 109 | Thunder | 115 |
| March | 24, 2022 | Warriors | 97 | 76ers | 83 |
| March | 27, 2022 | Magic | 132 | 76ers | 114 |
| March | 28, 2022 | 76ers | 79 | Bulls | 97 |
| March | 30, 2022 | 76ers | 95 | Rockets | 105 |
| April | 1, 2022 | Pacers | 119 | 76ers | 104 |
| April | 3, 2022 | Cavaliers | 131 | 76ers | 110 |
| April | 6, 2022 | Kings | 119 | 76ers | 91 |
| April | 8, 2022 | 76ers | 91 | Bucks | 123 |
| April | 10, 2022 | 76ers | 81 | Hornets | 93 |
| April | 11, 2022 | Celtics | 102 | 76ers | 88 |
| April | 14, 2022 | 76ers | 75 | Hawks | 95 |
| April | 16, 2022 | 76ers | 110 | Magic | 132 |
| April | 19, 2022 | Nets | 96 | 76ers | 83 |
| April | 21, 2022 | 76ers | 73 | Wolves | 91 |
| April | 23, 2022 | 76ers | 93 | Mavericks | 125 |
| April | 25, 2022 | 76ers | 82 | Hawks | 106 |
| April | 26, 2022 | Bucks | 124 | 76ers | 109 |
| April | 28, 2022 | 76ers | 102 | Bulls | 105 |
| April | 30, 2022 | 76ers | 95 | Heat | 112 |
| May | 1, 2022 | Bulls | 130 | 76ers | 105 |