| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Hawks | 94 | Wizards | 100 |
| November | 5, 2021 | 76ers | 87 | Wizards | 92 |
| November | 7, 2021 | Wizards | 121 | Kings | 124 |
| November | 8, 2021 | Magic | 98 | Wizards | 112 |
| November | 10, 2021 | Jazz | 128 | Wizards | 112 |
| November | 12, 2021 | Hornets | 102 | Wizards | 107 |
| November | 15, 2021 | Wizards | 99 | Trailblazers | 80 |
| November | 16, 2021 | Celtics | 107 | Wizards | 123 |
| November | 17, 2021 | Clippers | 95 | Wizards | 123 |
| November | 19, 2021 | Rockets | 104 | Wizards | 97 |
| November | 22, 2021 | Wolves | 97 | Wizards | 120 |
| November | 23, 2021 | Wizards | 79 | Pelicans | 84 |
| November | 26, 2021 | Wizards | 118 | Cavaliers | 106 |
| November | 29, 2021 | Knicks | 93 | Wizards | 88 |
| November | 30, 2021 | Lakers | 128 | Wizards | 111 |
| December | 2, 2021 | Wizards | 89 | Pistons | 98 |
| December | 5, 2021 | Pelicans | 107 | Wizards | 88 |
| December | 7, 2021 | Spurs | 97 | Wizards | 80 |
| December | 9, 2021 | Wizards | 109 | Bucks | 124 |
| December | 11, 2021 | Wizards | 99 | Nets | 111 |
| December | 14, 2021 | Pacers | 96 | Wizards | 136 |
| December | 17, 2021 | Wizards | 89 | Thunder | 102 |
| December | 20, 2021 | Grizzlies | 98 | Wizards | 102 |
| December | 23, 2021 | Raptors | 111 | Wizards | 119 |
| December | 26, 2021 | Hawks | 75 | Wizards | 79 |
| December | 28, 2021 | Wizards | 97 | Nuggets | 103 |
| December | 30, 2021 | Wizards | 107 | Magic | 101 |
| December | 31, 2021 | Heat | 75 | Wizards | 99 |
| January | 2, 2022 | Wizards | 101 | Bulls | 104 |
| January | 4, 2022 | Wizards | 95 | Hornets | 114 |
| January | 6, 2022 | Wizards | 112 | Celtics | 123 |
| January | 8, 2022 | Wizards | 91 | Warriors | 116 |
| January | 9, 2022 | Kings | 99 | Wizards | 114 |
| January | 12, 2022 | Wizards | 81 | Raptors | 119 |
| January | 14, 2022 | Pistons | 87 | Wizards | 85 |
| January | 15, 2022 | Wizards | 83 | Raptors | 130 |
| January | 17, 2022 | Wizards | 103 | Mavericks | 117 |
| January | 18, 2022 | Heat | 99 | Wizards | 83 |
| January | 20, 2022 | Nets | 99 | Wizards | 98 |
| January | 23, 2022 | Wizards | 112 | Pacers | 115 |
| January | 25, 2022 | Wizards | 104 | Bulls | 92 |
| January | 27, 2022 | Nuggets | 83 | Wizards | 102 |
| January | 30, 2022 | Warriors | 148 | Wizards | 144 |
| January | 31, 2022 | Wizards | 109 | Wolves | 94 |
| February | 2, 2022 | Wizards | 102 | 76ers | 95 |
| February | 4, 2022 | Bucks | 113 | Wizards | 98 |
| February | 6, 2022 | Wizards | 95 | Pistons | 80 |
| February | 13, 2022 | Trailblazers | 88 | Wizards | 85 |
| February | 16, 2022 | Wizards | 69 | Rockets | 85 |
| February | 18, 2022 | Bulls | 96 | Wizards | 88 |
| February | 20, 2022 | Mavericks | 105 | Wizards | 94 |
| February | 23, 2022 | Wizards | 114 | Celtics | 107 |
| February | 24, 2022 | Wizards | 92 | Heat | 87 |
| February | 26, 2022 | Cavaliers | 119 | Wizards | 125 |
| February | 28, 2022 | Wizards | 100 | Lakers | 142 |
| March | 2, 2022 | Thunder | 115 | Wizards | 127 |
| March | 5, 2022 | Pacers | 116 | Wizards | 113 |
| March | 8, 2022 | Wizards | 104 | Clippers | 102 |
| March | 11, 2022 | Cavaliers | 107 | Wizards | 104 |
| March | 14, 2022 | Wizards | 104 | Grizzlies | 139 |
| March | 15, 2022 | Wizards | 84 | 76ers | 88 |
| March | 17, 2022 | Suns | 100 | Wizards | 108 |
| March | 18, 2022 | 76ers | 102 | Wizards | 96 |
| March | 21, 2022 | Wizards | 110 | Nets | 124 |
| March | 22, 2022 | Wizards | 71 | Hawks | 93 |
| March | 25, 2022 | Knicks | 76 | Wizards | 98 |
| March | 26, 2022 | Wizards | 102 | Spurs | 128 |
| March | 29, 2022 | Wizards | 129 | Magic | 113 |
| March | 31, 2022 | Hornets | 104 | Wizards | 108 |
| April | 2, 2022 | Celtics | 109 | Wizards | 131 |
| April | 5, 2022 | Wizards | 117 | Hornets | 100 |
| April | 7, 2022 | Wizards | 99 | Suns | 90 |
| April | 8, 2022 | Pistons | 111 | Wizards | 117 |
| April | 12, 2022 | Wizards | 100 | Heat | 112 |
| April | 14, 2022 | Wizards | 121 | Jazz | 130 |
| April | 17, 2022 | Bulls | 102 | Wizards | 121 |
| April | 20, 2022 | Wizards | 114 | Knicks | 105 |
| April | 22, 2022 | Wizards | 102 | Cavaliers | 119 |
| April | 24, 2022 | Raptors | 129 | Wizards | 112 |
| April | 27, 2022 | Wizards | 92 | Bucks | 113 |
| April | 29, 2022 | Nets | 84 | Wizards | 93 |
| May | 1, 2022 | Wizards | 108 | Pacers | 122 |