| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Kings | 88 | Trailblazers | 110 |
| November | 5, 2021 | Trailblazers | 81 | Mavericks | 100 |
| November | 8, 2021 | Trailblazers | 94 | Cavaliers | 101 |
| November | 10, 2021 | Trailblazers | 117 | Lakers | 102 |
| November | 13, 2021 | Trailblazers | 70 | Wolves | 95 |
| November | 15, 2021 | Wizards | 99 | Trailblazers | 80 |
| November | 17, 2021 | Suns | 81 | Trailblazers | 91 |
| November | 19, 2021 | Trailblazers | 89 | Nuggets | 91 |
| November | 21, 2021 | Bucks | 96 | Trailblazers | 110 |
| November | 23, 2021 | Trailblazers | 80 | Suns | 119 |
| November | 25, 2021 | Hawks | 92 | Trailblazers | 102 |
| November | 27, 2021 | Trailblazers | 82 | Spurs | 108 |
| November | 28, 2021 | Thunder | 100 | Trailblazers | 77 |
| November | 30, 2021 | Trailblazers | 84 | Pacers | 116 |
| December | 2, 2021 | Grizzlies | 92 | Trailblazers | 97 |
| December | 5, 2021 | Trailblazers | 87 | Heat | 102 |
| December | 6, 2021 | Trailblazers | 77 | 76ers | 94 |
| December | 8, 2021 | Trailblazers | 82 | Raptors | 112 |
| December | 11, 2021 | Rockets | 98 | Trailblazers | 81 |
| December | 13, 2021 | Clippers | 105 | Trailblazers | 109 |
| December | 15, 2021 | Trailblazers | 92 | Knicks | 96 |
| December | 17, 2021 | Trailblazers | 82 | Celtics | 91 |
| December | 20, 2021 | Celtics | 78 | Trailblazers | 97 |
| December | 21, 2021 | Trailblazers | 65 | Warriors | 116 |
| December | 23, 2021 | Pelicans | 79 | Trailblazers | 100 |
| December | 26, 2021 | Wolves | 111 | Trailblazers | 88 |
| December | 27, 2021 | Trailblazers | 92 | Suns | 104 |
| December | 29, 2021 | Mavericks | 83 | Trailblazers | 81 |
| December | 30, 2021 | Trailblazers | 89 | Jazz | 101 |
| January | 2, 2022 | Trailblazers | 109 | Kings | 126 |
| January | 5, 2022 | Clippers | 90 | Trailblazers | 74 |
| January | 8, 2022 | Lakers | 89 | Trailblazers | 98 |
| January | 10, 2022 | Trailblazers | 89 | Nuggets | 81 |
| January | 11, 2022 | Jazz | 90 | Trailblazers | 95 |
| January | 13, 2022 | Trailblazers | 98 | Magic | 117 |
| January | 15, 2022 | Trailblazers | 75 | Warriors | 100 |
| January | 18, 2022 | Trailblazers | 51 | Pistons | 67 |
| January | 21, 2022 | Trailblazers | 80 | Bulls | 90 |
| January | 23, 2022 | Trailblazers | 90 | Hornets | 84 |
| January | 25, 2022 | Rockets | 94 | Trailblazers | 75 |
| January | 28, 2022 | Trailblazers | 63 | Hawks | 119 |
| February | 1, 2022 | Spurs | 109 | Trailblazers | 96 |
| February | 4, 2022 | Lakers | 119 | Trailblazers | 109 |
| February | 7, 2022 | Mavericks | 96 | Trailblazers | 77 |
| February | 13, 2022 | Trailblazers | 88 | Wizards | 85 |
| February | 15, 2022 | Magic | 130 | Trailblazers | 122 |
| February | 17, 2022 | Pacers | 124 | Trailblazers | 101 |
| February | 18, 2022 | 76ers | 90 | Trailblazers | 118 |
| February | 20, 2022 | Trailblazers | 80 | Pelicans | 95 |
| February | 22, 2022 | Nets | 82 | Trailblazers | 96 |
| February | 25, 2022 | Nuggets | 92 | Trailblazers | 102 |
| February | 27, 2022 | Trailblazers | 104 | Kings | 122 |
| March | 1, 2022 | Raptors | 111 | Trailblazers | 82 |
| March | 3, 2022 | Trailblazers | 94 | Rockets | 104 |
| March | 4, 2022 | Grizzlies | 72 | Trailblazers | 98 |
| March | 6, 2022 | Trailblazers | 98 | Lakers | 119 |
| March | 9, 2022 | Warriors | 91 | Trailblazers | 82 |
| March | 12, 2022 | Heat | 89 | Trailblazers | 80 |
| March | 13, 2022 | Hornets | 85 | Trailblazers | 77 |
| March | 15, 2022 | Trailblazers | 60 | Mavericks | 86 |
| March | 18, 2022 | Warriors | 117 | Trailblazers | 112 |
| March | 21, 2022 | Cavaliers | 102 | Trailblazers | 95 |
| March | 24, 2022 | Trailblazers | 79 | Pelicans | 98 |
| March | 27, 2022 | Bulls | 90 | Trailblazers | 86 |
| March | 29, 2022 | Trailblazers | 84 | Grizzlies | 101 |
| March | 31, 2022 | Knicks | 100 | Trailblazers | 96 |
| April | 2, 2022 | Nuggets | 87 | Trailblazers | 98 |
| April | 4, 2022 | Trailblazers | 80 | Nets | 79 |
| April | 6, 2022 | Trailblazers | 84 | Spurs | 109 |
| April | 9, 2022 | Trailblazers | 77 | Thunder | 102 |
| April | 12, 2022 | Jazz | 95 | Trailblazers | 98 |
| April | 14, 2022 | Trailblazers | 76 | Bucks | 105 |
| April | 16, 2022 | Spurs | 92 | Trailblazers | 113 |
| April | 17, 2022 | Trailblazers | 87 | Grizzlies | 103 |
| April | 19, 2022 | Thunder | 89 | Trailblazers | 104 |
| April | 21, 2022 | Trailblazers | 101 | Clippers | 97 |
| April | 22, 2022 | Wolves | 85 | Trailblazers | 86 |
| April | 24, 2022 | Trailblazers | 71 | Jazz | 72 |
| April | 25, 2022 | Trailblazers | 82 | Rockets | 105 |
| April | 27, 2022 | Trailblazers | 96 | Clippers | 99 |
| April | 29, 2022 | Suns | 100 | Trailblazers | 95 |
| May | 1, 2022 | Pistons | 100 | Trailblazers | 92 |